WO2004067721A3 - Transcetolases modificatrices du chemin de la beta-catenine, et mode d'utilisation - Google Patents

Transcetolases modificatrices du chemin de la beta-catenine, et mode d'utilisation Download PDF

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Publication number
WO2004067721A3
WO2004067721A3 PCT/US2004/002321 US2004002321W WO2004067721A3 WO 2004067721 A3 WO2004067721 A3 WO 2004067721A3 US 2004002321 W US2004002321 W US 2004002321W WO 2004067721 A3 WO2004067721 A3 WO 2004067721A3
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WO
WIPO (PCT)
Prior art keywords
beta
methods
tkts
modifiers
catenin pathway
Prior art date
Application number
PCT/US2004/002321
Other languages
English (en)
Other versions
WO2004067721A2 (fr
Inventor
Helen Francis-Lang
Christopher G Winter
Richard Benn Abegania Ventura
Kim Lickteig
Original Assignee
Exelixis Inc
Helen Francis-Lang
Christopher G Winter
Richard Benn Abegania Ventura
Kim Lickteig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Helen Francis-Lang, Christopher G Winter, Richard Benn Abegania Ventura, Kim Lickteig filed Critical Exelixis Inc
Priority to AU2004207272A priority Critical patent/AU2004207272A1/en
Priority to EP04706014A priority patent/EP1587911A4/fr
Priority to CA002513601A priority patent/CA2513601A1/fr
Priority to JP2006503093A priority patent/JP2007524355A/ja
Priority to US10/543,639 priority patent/US20070020628A1/en
Publication of WO2004067721A2 publication Critical patent/WO2004067721A2/fr
Publication of WO2004067721A3 publication Critical patent/WO2004067721A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Des gènes humains des transcétolases sont identifiés comme modulateurs du chemin de la bêta-cathénine. Ils constituent donc des cibles thérapeutiques pour des troubles associés à une déficience de la fonction bêta-cathénine. L'invention concerne ainsi des procédés permettant d'identifier des modulateurs de la bêta-caténine, par recherche systématique d'agents qui modulent l'activité de la transcétolase.
PCT/US2004/002321 2003-01-29 2004-01-28 Transcetolases modificatrices du chemin de la beta-catenine, et mode d'utilisation WO2004067721A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2004207272A AU2004207272A1 (en) 2003-01-29 2004-01-28 TKTS as modifiers of the beta-catenin pathway and methods of use
EP04706014A EP1587911A4 (fr) 2003-01-29 2004-01-28 Transcetolases modificatrices du chemin de la beta-catenine, et mode d'utilisation
CA002513601A CA2513601A1 (fr) 2003-01-29 2004-01-28 Transcetolases modificatrices du chemin de la beta-catenine, et mode d'utilisation
JP2006503093A JP2007524355A (ja) 2003-01-29 2004-01-28 βカテニン経路のモディファイヤーとしてのＴＫＴｓ及び使用方法
US10/543,639 US20070020628A1 (en) 2004-01-28 2004-01-28 Tkts as mondifiers of the beta-catenin pathway and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44347803P 2003-01-29 2003-01-29
US60/443,478 2003-01-29

Publications (2)

Publication Number Publication Date
WO2004067721A2 WO2004067721A2 (fr) 2004-08-12
WO2004067721A3 true WO2004067721A3 (fr) 2006-12-14

Family

ID=32825336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002321 WO2004067721A2 (fr) 2003-01-29 2004-01-28 Transcetolases modificatrices du chemin de la beta-catenine, et mode d'utilisation

Country Status (5)

Country Link
EP (1) EP1587911A4 (fr)
JP (1) JP2007524355A (fr)
AU (1) AU2004207272A1 (fr)
CA (1) CA2513601A1 (fr)
WO (1) WO2004067721A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099122A1 (fr) * 2001-06-05 2002-12-12 Exelixis, Inc. Modificateurs de la voie p53 et methodes d'utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099122A1 (fr) * 2001-06-05 2002-12-12 Exelixis, Inc. Modificateurs de la voie p53 et methodes d'utilisation

Also Published As

Publication number Publication date
WO2004067721A2 (fr) 2004-08-12
JP2007524355A (ja) 2007-08-30
AU2004207272A1 (en) 2004-08-12
EP1587911A2 (fr) 2005-10-26
EP1587911A4 (fr) 2007-09-12
CA2513601A1 (fr) 2004-08-12

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