WO2004067700A2 - Systeme de transfert de liquides - Google Patents

Systeme de transfert de liquides Download PDF

Info

Publication number
WO2004067700A2
WO2004067700A2 PCT/GB2004/000383 GB2004000383W WO2004067700A2 WO 2004067700 A2 WO2004067700 A2 WO 2004067700A2 GB 2004000383 W GB2004000383 W GB 2004000383W WO 2004067700 A2 WO2004067700 A2 WO 2004067700A2
Authority
WO
WIPO (PCT)
Prior art keywords
pin
liquid
capillary
tip
substrate
Prior art date
Application number
PCT/GB2004/000383
Other languages
English (en)
Other versions
WO2004067700A3 (fr
Inventor
Stuart Elmes
Jonathan Pearson
Alastair Taylor
Colin Reynolds
Dan Aldridge
Original Assignee
Apogent Robotics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0302281.1A external-priority patent/GB0302281D0/en
Application filed by Apogent Robotics Limited filed Critical Apogent Robotics Limited
Priority to EP04706726A priority Critical patent/EP1594951A2/fr
Publication of WO2004067700A2 publication Critical patent/WO2004067700A2/fr
Publication of WO2004067700A3 publication Critical patent/WO2004067700A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/022—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle
    • B01L2400/025—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle tapping tip on substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

L'invention porte sur un outil de transfert de liquides comprenant une aiguille capillaire céramique percée d'un canal capillaire s'étendant sur toute sa longueur, et un porte-aiguille consistant en un manche métallique allongé dont l'extrémité distale permet de saisir l'extrémité proximale de l'aiguille, dont l'extrémité proximale comporte un renflement, et qui est percé d'un évent radial communiquant avec le canal capillaire de l'aiguille. L'invention porte également sur une technique de nettoyage d'un outil de transfert de liquides comprenant un ensemble d'aiguilles capillaires de transfert de volumes donnés de liquides entre leur extrémité et un substrat. Ladite technique consiste à insérer les extrémités des aiguilles dans autant de lamages reliés à une pompe à vide et munis chacun d'un joint d'un diamètre extérieur inférieur à celui du lamage et placé à sa base de manière à permettre un déplacement radial de l'aiguille compensant les défauts d'alignement entre les aiguilles et les axes des lamages, tout en assurant une bonne étanchéité entre les lamages et leurs aiguilles respectives.
PCT/GB2004/000383 2003-01-31 2004-01-30 Systeme de transfert de liquides WO2004067700A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04706726A EP1594951A2 (fr) 2003-01-31 2004-01-30 Systeme de transfert de liquides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0302281.1A GB0302281D0 (en) 2003-01-31 2003-01-31 Liquid transfer system
GB0302281.1 2003-01-31
US10/655,714 2003-09-05
US10/655,714 US20050079621A1 (en) 2003-01-31 2003-09-05 Liquid transfer system

Publications (2)

Publication Number Publication Date
WO2004067700A2 true WO2004067700A2 (fr) 2004-08-12
WO2004067700A3 WO2004067700A3 (fr) 2004-10-21

Family

ID=32827041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000383 WO2004067700A2 (fr) 2003-01-31 2004-01-30 Systeme de transfert de liquides

Country Status (2)

Country Link
EP (1) EP1594951A2 (fr)
WO (1) WO2004067700A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005115619A1 (fr) * 2004-05-28 2005-12-08 Tops-Pin Aps Aiguille de microdepot pour production de biopuces
EP1654067A2 (fr) * 2003-07-11 2006-05-10 Genomic Solutions, Inc. Appareil et procedes destines a la manipulation d'echantillons liquides, utilisant l'action capillaire
WO2019202102A1 (fr) * 2018-04-18 2019-10-24 Biosurfit Sa Dispositif de transfert d'échantillon

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
WO2000001798A2 (fr) * 1998-07-07 2000-01-13 Cartesian Technologies, Inc. Modele de pointe et matrice a acces selectif pour transfert micro-fluidique
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
WO2001066251A2 (fr) * 2000-03-07 2001-09-13 Biotage, Inc. Dispositif de transfert de liquide
WO2002063272A2 (fr) * 2001-02-06 2002-08-15 Parallel Synthesis Technologies Dispositif de depot microfabrique destine a former des jeux ordonnes de microdepots de faible cout

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
WO2000001798A2 (fr) * 1998-07-07 2000-01-13 Cartesian Technologies, Inc. Modele de pointe et matrice a acces selectif pour transfert micro-fluidique
WO2001066251A2 (fr) * 2000-03-07 2001-09-13 Biotage, Inc. Dispositif de transfert de liquide
WO2002063272A2 (fr) * 2001-02-06 2002-08-15 Parallel Synthesis Technologies Dispositif de depot microfabrique destine a former des jeux ordonnes de microdepots de faible cout

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1654067A2 (fr) * 2003-07-11 2006-05-10 Genomic Solutions, Inc. Appareil et procedes destines a la manipulation d'echantillons liquides, utilisant l'action capillaire
EP1654067A4 (fr) * 2003-07-11 2008-01-02 Genomic Solutions Inc Appareil et procedes destines a la manipulation d'echantillons liquides, utilisant l'action capillaire
WO2005115619A1 (fr) * 2004-05-28 2005-12-08 Tops-Pin Aps Aiguille de microdepot pour production de biopuces
WO2019202102A1 (fr) * 2018-04-18 2019-10-24 Biosurfit Sa Dispositif de transfert d'échantillon

Also Published As

Publication number Publication date
WO2004067700A3 (fr) 2004-10-21
EP1594951A2 (fr) 2005-11-16

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