WO2004063709A8 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators - Google Patents

Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators

Info

Publication number
WO2004063709A8
WO2004063709A8 PCT/US2004/000368 US2004000368W WO2004063709A8 WO 2004063709 A8 WO2004063709 A8 WO 2004063709A8 US 2004000368 W US2004000368 W US 2004000368W WO 2004063709 A8 WO2004063709 A8 WO 2004063709A8
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
methods
growth factor
mammal
factor receptor
Prior art date
Application number
PCT/US2004/000368
Other languages
French (fr)
Other versions
WO2004063709A2 (en
WO2004063709A3 (en
Inventor
Lukas C Amler
Thomas Januario
Original Assignee
Bristol Myers Squibb Co
Lukas C Amler
Thomas Januario
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Lukas C Amler, Thomas Januario filed Critical Bristol Myers Squibb Co
Priority to JP2006500841A priority Critical patent/JP2007520995A/en
Priority to EP04700860A priority patent/EP1597558A2/en
Priority to CA002512536A priority patent/CA2512536A1/en
Priority to US10/541,749 priority patent/US20060234237A1/en
Publication of WO2004063709A2 publication Critical patent/WO2004063709A2/en
Publication of WO2004063709A8 publication Critical patent/WO2004063709A8/en
Publication of WO2004063709A3 publication Critical patent/WO2004063709A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

EGFR biomakers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal level of at least one biomaker, wherein a difference in the level in at least one biomaker measured in (b) compared to the level of the biomaker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
PCT/US2004/000368 2003-01-08 2004-01-08 Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators WO2004063709A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006500841A JP2007520995A (en) 2003-01-08 2004-01-08 Biomarkers and methods for determining susceptibility to epidermal growth factor receptor modulators
EP04700860A EP1597558A2 (en) 2003-01-08 2004-01-08 Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
CA002512536A CA2512536A1 (en) 2003-01-08 2004-01-08 Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
US10/541,749 US20060234237A1 (en) 2004-01-08 2004-01-08 Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43873503P 2003-01-08 2003-01-08
US60/438,735 2003-01-08

Publications (3)

Publication Number Publication Date
WO2004063709A2 WO2004063709A2 (en) 2004-07-29
WO2004063709A8 true WO2004063709A8 (en) 2005-03-31
WO2004063709A3 WO2004063709A3 (en) 2008-05-15

Family

ID=32713370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/000368 WO2004063709A2 (en) 2003-01-08 2004-01-08 Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators

Country Status (4)

Country Link
EP (1) EP1597558A2 (en)
JP (1) JP2007520995A (en)
CA (1) CA2512536A1 (en)
WO (1) WO2004063709A2 (en)

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US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

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AU2005249492B2 (en) 2004-05-27 2011-09-22 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
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US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Also Published As

Publication number Publication date
CA2512536A1 (en) 2004-07-29
WO2004063709A2 (en) 2004-07-29
WO2004063709A3 (en) 2008-05-15
EP1597558A2 (en) 2005-11-23
JP2007520995A (en) 2007-08-02

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