WO2004060916A3 - Peptide compound containing boron - Google Patents

Peptide compound containing boron Download PDF

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Publication number
WO2004060916A3
WO2004060916A3 PCT/DE2003/004216 DE0304216W WO2004060916A3 WO 2004060916 A3 WO2004060916 A3 WO 2004060916A3 DE 0304216 W DE0304216 W DE 0304216W WO 2004060916 A3 WO2004060916 A3 WO 2004060916A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivative
containing boron
peptide compound
compound containing
peptide
Prior art date
Application number
PCT/DE2003/004216
Other languages
German (de)
French (fr)
Other versions
WO2004060916A2 (en
Inventor
Lutz Tietze
Ulrich Griesbach
Original Assignee
Univ Goettingen Georg August
Lutz Tietze
Ulrich Griesbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Goettingen Georg August, Lutz Tietze, Ulrich Griesbach filed Critical Univ Goettingen Georg August
Priority to EP03795776A priority Critical patent/EP1583775A2/en
Priority to AU2003298079A priority patent/AU2003298079A1/en
Publication of WO2004060916A2 publication Critical patent/WO2004060916A2/en
Publication of WO2004060916A3 publication Critical patent/WO2004060916A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]

Abstract

Disclosed is a peptide compound comprising at least one derivative of a peptide ligand of a receptor that occurs naturally in the body and at least one component containing boron. Preferably, said derivative of a peptide ligand represents a gastrin derivative. In an advantageous embodiment of the invention, said derivative encompasses the amino acid sequence Trp-Met-Asp-Phe-NH2.
PCT/DE2003/004216 2003-01-06 2003-12-19 Peptide compound containing boron WO2004060916A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03795776A EP1583775A2 (en) 2003-01-06 2003-12-19 Peptide compound containing boron
AU2003298079A AU2003298079A1 (en) 2003-01-06 2003-12-19 Peptide compound containing boron

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003100361 DE10300361A1 (en) 2003-01-06 2003-01-06 Drilled peptide compound
DE10300361.4 2003-01-06

Publications (2)

Publication Number Publication Date
WO2004060916A2 WO2004060916A2 (en) 2004-07-22
WO2004060916A3 true WO2004060916A3 (en) 2004-12-02

Family

ID=32519703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/004216 WO2004060916A2 (en) 2003-01-06 2003-12-19 Peptide compound containing boron

Country Status (4)

Country Link
EP (1) EP1583775A2 (en)
AU (1) AU2003298079A1 (en)
DE (1) DE10300361A1 (en)
WO (1) WO2004060916A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220018A (en) * 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5955586A (en) * 1996-03-22 1999-09-21 Sessler; Jonathan L. Highly boronated derivatives of texaphyrins
WO2003040175A1 (en) * 2001-11-08 2003-05-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Conjugate for treating by boron neutron capture (bnc) radiation-resistant tumours

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220018A (en) * 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5955586A (en) * 1996-03-22 1999-09-21 Sessler; Jonathan L. Highly boronated derivatives of texaphyrins
WO2003040175A1 (en) * 2001-11-08 2003-05-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Conjugate for treating by boron neutron capture (bnc) radiation-resistant tumours

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CELL AND TISSUE RESEARCH, vol. 287, no. 2, 1997, pages 325 - 333, ISSN: 0302-766X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, TARASOVA NADYA I ET AL: "Endocytosis of gastrin in cancer cells expressing gastrin/CCK-B receptor", XP002294919, Database accession no. PREV199799426169 *
FEVIG J M ET AL: "Design and synthesis of ring-constrained boropeptide thrombin inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 3, 6 February 1996 (1996-02-06), pages 295 - 300, XP004135081, ISSN: 0960-894X *
KANE ROBERT R ET AL: "Solution-phase segment synthesis of boron-rich peptides", JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 5, 1993, pages 991 - 992, XP002294917, ISSN: 0022-3263 *
NEMOTO HISAO ET AL: "Synthesis and biological properties of water-soluble p-boronophenylalanine derivatives: Relationship between water solubility, cytotoxicity, and cellular uptake", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 10, 1995, pages 1673 - 1678, XP002294784, ISSN: 0022-2623 *
SJÖBERG S ET AL: "Chemistry and biology of some low molecular weight boron compounds for boron neutron capture therapy.", JOURNAL OF NEURO-ONCOLOGY. NETHERLANDS MAY 1997, vol. 33, no. 1-2, May 1997 (1997-05-01), pages 41 - 52, XP009030955, ISSN: 0167-594X *
VARADARAJAN A ET AL: "NOVEL CARBORANYL AMINO ACIDS AND PEPTIDES REAGENTS FOR ANTIBODY MODIFICATION AND SUBSEQUENT NEUTRON-CAPTURE STUDIES", BIOCONJUGATE CHEMISTRY, vol. 2, no. 4, 1991, pages 242 - 253, XP002294918, ISSN: 1043-1802 *
YANG W ET AL: "Boronic acid compounds as potential pharmaceutical agents", MEDICINAL RESEARCH REVIEWS 2003 UNITED STATES, vol. 23, no. 3, 2003, pages 346 - 368, XP009030957, ISSN: 0198-6325 *

Also Published As

Publication number Publication date
WO2004060916A2 (en) 2004-07-22
AU2003298079A1 (en) 2004-07-29
EP1583775A2 (en) 2005-10-12
DE10300361A1 (en) 2004-07-15

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