WO2004060374A1 - Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders - Google Patents
Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders Download PDFInfo
- Publication number
- WO2004060374A1 WO2004060374A1 PCT/JP2003/016724 JP0316724W WO2004060374A1 WO 2004060374 A1 WO2004060374 A1 WO 2004060374A1 JP 0316724 W JP0316724 W JP 0316724W WO 2004060374 A1 WO2004060374 A1 WO 2004060374A1
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- WIPO (PCT)
- Prior art keywords
- aripiprazole
- disorder
- serotonin reuptake
- depression
- mood
- Prior art date
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Classifications
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Definitions
- the present invention provides pharmaceutical compositions comprising carbostyril derivatives that act as dopamine-serotonin system stabilizers in combination with serotonin reuptake inhibitors in a pharmaceutically acceptable carrier. Further, the present invention provides methods of using the compositions of the present invention to treat mood disorders such as depression and major depressive disorder.
- depression is a major social problem throughout the world. For example, in Japan the occurrence rate of depression in the generation older than 65 years is 5% or more, including major depressive disorder. Some of the depression in this population is associated with mental disturbances representing senile diseases associated with dementia and neurosis. Many depressed patients show high recurrence rate, and severe depressive symptoms are major causes of suicide and drug abuse (Nishimura Ken, "NIPPON RONEN IGAKUZASSHI", Vol. 33, pp 503-504 (1996)).
- tricyclic antidepressant drugs e.g., imipramine, desipramine, amitriptyline, etc.
- these drugs have side-effects such as the following: dry mouth, hazy eyes, dysuria, constipation, recognition disturbance and the like due to anticholinergic activity; cardiovascular side-effects such as, orthostatic hypotension, tachycardia and the like on the basis of ⁇ adrenoreceptor antagonist activity; side-effects such as, sedation, increase in the body weight and the like on the basis of histamine- H x receptor antagonist activity.
- serotonin reuptake inhibitors have been developed, including but not limited to fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, escitalopram, fluvoxamine, paroxetine and sertraline, and these inhibitors have side-effects such as recognition disturbance, sleep disturbance, and excerbation of anxiety and agitation. Additionally, these inhibitors also have other side effects in the digestive organs, such as nausea, vomiting and the like.
- the mood disorders including depression and major depressive disorder are heterogeneous diseases, and the causes of these diseases are not been fully understood, it is likely that the abnormalities of monoaminergic central nervous system caused by serotonin, norepinephrine and dopamine and the like, and the abnormality of various hormones and peptides as well as various stressors are causes of depression and various mood disorders (Kubota Masaharu et al., "RINSHOU SEISHIN IGAKU", Vol. 29, pp 891-899 (2000) ) .
- antidepressant drugs such as tricyclic antidepressants and serotonin reuptake inhibitors were used, these drugs are not always effective in treating all depressed patients.
- New therapeutic trials involve proposed combined therapies using an atypical antipsychotic drug, such as olanzapine, which is an agent for treating for schizophrenia (antipsychotic drug) , together with an antidepressant drug such as serotonin reuptake inhibitor (EP 0 367 141, WO 98/11897, WO99/61027, W099/62522, U.S. 2002/0123490A1 and the like) .
- an antidepressant drug such as serotonin reuptake inhibitor
- commercially available atypical antipsychotic drugs have significant problems relating to their safety. For example, clozapine, olanzapine and quetiapine increase body weight and enhance the risk of diabetes mellitus (Newcomer, J. W.
- Risperidone causes increases serum prolactin levels and produces extrapyramidal side effects at high dosages. Ziprasidone enhances the risk of severe arrhythmia on the basis of cardio-QTc prolongation action. Further, clozapine induces agranulocytosis, so that clinical use thereof is strictly restricted (van Kammen, D. P. (Compiled under Supervision by Murasaki Mitsuroh) , "RINSHOU SEISHIN YAKURI", Vol. 4, pp 483-492 (2001)).
- compositions useful for treating mood disorders particularly, depression and major depressive disorder, which are efficacious and do not cause the deleterious side effects associated with prior art compounds.
- the present invention solves the problem described above by providing novel compositions and methods of using these compositions for treating mood disorders, particularly depression and major depressive disorder.
- the present invention provides solutions to the above-mentioned problems, and demonstrates that the mood disorders such as depression, major depressive and the like can be treated effectively by administering to a patient with such disorder a pharmaceutical composition comprising at least one carbostyril derivative that is a dopamine-serotonin system stabilizer in combination with at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier.
- a preferred carbostyril derivative of the present invention that is a dopamine-serotonin system stabilizer is aripiprazole or a metabolite thereof.
- Another preferred carbostyril derivative of the present invention that is a dopamine-serotonin system stabilizer is a metabolite of aripiprazole called dehydroaripiprazole, also known as OPC-14857.
- Other such metabolites of aripiprazole included within the present invention are shown in Figure 8.
- Preferred metabolites are shown in Figure 8 indicated by the following designations: OPC-14857, DM-1458, DM-1451, DM-1452, DM-1454 and DCPP.
- Aripiprazole also called 7- ⁇ 4- [4- (2, 3- dichlorophenyl) -1-piperazinyl] butoxy ⁇ -3, 4-dihydro- 2 (IH) -quinolinone, is a carbostyril compound and is useful for treating schizophrenia (EP 0 367 141, U.S. Patent No. 5,006,528).
- Aripiprazole is also known as 7- ⁇ 4- [4- (2, 3-dichlorophenyl) -l-piperazinyl]butoxy ⁇ -3, 4- dihydrocarbostyril, Abilify, OPC-14597, OPC-31 and BMS- 337039.
- Aripiprazole possesses 5-HT1A receptor agonist activity, and is known as useful compound for treating types of depression and refractory depressions, such as endogeneous depression, major depression, melancholia and the like (WO 02/060423, U. S. Patent Application 2002/0173513A1) .
- Aripiprazole has activity as an agonist at the serotonin receptors and dopamine receptors, and acts as an agonist or partial agonist at the serotonin 5-HT1A receptor and as an agonist or partial agonist at the dopamine D 2 receptor.
- Aripiprazole is a dopamine-serotonin system stabilizer. Metabolites of aripiprazole are included within the scope of the present invention.
- aripiprazole One such metabolite of aripiprazole is called dehydroaripiprazole.
- Other such metabolites of aripiprazole included within the present invention are shown in Figure 8.
- Preferred metabolites- are shown in Figure 8 indicated by the following designations: OPC-14857, DM-1458, DM-1451, DM-1452, DM- 1454 and DCPP.
- the at least one serotonin reuptake inhibitor used in the present invention includes but is not limited to the following: fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine, sertraline, escitalopram and salts thereof.
- the pharmaceutical composition comprises aripiprazole and citalopram in a pharmaceutically acceptable carrier.
- compositions of present invention comprising at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier may be combined in one dosage form, for example a pill.
- the at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and the at least one serotonin reuptake inhibitor may be in separate dosage forms, each in a pharmaceutically acceptable carrier.
- These compositions are administered to a patient with a mood disorder, particularly depression or major depressive disorder, in an amount and dosage regimen effective to treat the mood disorder.
- Yet another object of the present invention is to provide a composition
- a composition comprising at least one carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier, wherein the carbostyril derivative is aripiprazole and the serotonin reuptake inhibitor is citalopram.
- Yet another object of the present invention is to provide a composition
- a composition comprising at least one carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor, wherein the carbostyril derivative with activity as a dopamine-serotonin system stabilizer is a metabolite of aripiprazole and is dehydroaripiprazole (OPC-14857), DM-1458, DM-1451, DM- 1452, DM-1454 or DCPP.
- Yet another object of the present invention is to provide a composition comprising at least one carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor, wherein the carbostyril derivative is dehydroaripiprazole.
- Yet another object of the present invention is to provide a use of a composition comprising a carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier in the preparation of a medicament for treatment of mood disorders, wherein the carbostyril derivative is aripiprazole or a metabolite thereof.
- Yet another object of the present invention is to provide a use of a composition comprising a carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier in the preparation of a medicament for treatment of mood disorders, wherein at least one carbostyril derivative is aripiprazole and at least one serotonin reuptake inhibitor is citalopram.
- Yet another object of the present invention is to provide a use of a composition comprising at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and at least one serotonin reuptake inhibitor pharmaceutically acceptable carrier in the preparation of a medicament for treatment of mood disorders, wherein the carbostyril derivative with activity as a dopamine- serotonin system stabilizer is a metabolite of aripiprazole and is dehydroaripiprazole (OPC-14857), DM-1458, DM-1451, DM-1452, DM-1454 or DCPP.
- OPC-14857 dehydroaripiprazole
- Yet another object of the present invention is to provide a use of a composition comprising a carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier in the preparation of a medicament for treatment of mood disorders, wherein the carbostyril derivative is dehydroaripiprazole.
- It is another object of the present invention to provide a method for treating a mood disorder comprising administration to a patient with a mood disorder of a composition comprising at least one carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor together in a pharmaceutically acceptable carrier, wherein the carbostyril derivative is aripiprazole or a metabolite thereof.
- It is another object of the present invention to provide a method for treating major depressive disorder comprising administration to a patient with major depressive disorder of a composition comprising a carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor together with a pharmaceutically acceptable carrier, wherein the carbostyril derivative is aripiprazole and the serotonin reuptake inhibitor is citalopram.
- Still another object of the present invention is to provide a method for treating a mood disorder comprising administration to a patient with a mood disorder of a composition comprising at least one carbostyril derivative with activity as a dopamine- serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier, wherein the carbostyril derivative is a metabolite of aripiprazole and is dehydroaripiprazole (OPC-14857), DM-1458, DM-1451, DM-1452, DM-1454 or DCPP.
- OPC-14857 dehydroaripiprazole
- Yet another object of the present invention is to provide a method for treating major depressive disorder comprising administration to a patient with major depressive disorder of a composition comprising at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier, wherein the mood disorder is major depressive disorder. It is another object of the present invention to provide a method for treating major depressive disorder comprising administration to a patient with major depressive disorder of a composition comprising at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier.
- It is another object of the present invention to provide a method for treating major depressive disorder comprising administration to a patient with major depressive disorder of a composition comprising at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and at least one serotonin reuptake inhibitor together with a pharmaceutically acceptable carrier, wherein the carbostyril derivative is aripiprazole or a metabolite thereof.
- Still another object of the present invention is to provide a method for treating major depressive disorder comprising administration to a patient with major depressive disorder of a composition comprising at least one carbostyril derivative with activity as a dopamine-serotonin system stabilizer and at least one serotonin reuptake inhibitor in a pharmaceutically acceptable carrier, wherein the carbostyril derivative is a metabolite of aripiprazole and is. dehydroaripiprazole (OPC-14857), DM-1458, DM-1451, DM-1452, DM-1454 or DCPP.
- OPC-14857 dehydroaripiprazole
- DM-1458 DM-1451, DM-1452, DM-1454 or DCPP.
- Figure 1 is the thermogravimetric/ differential thermogra of the aripiprazole hydrate A obtained in Reference Example 4.
- Figure 2 is the X H-NMR spectrum (DMS0-d 6 , TMS) of the aripiprazole hydrate A obtained in Reference Example 4.
- Figure 3 is the powder X-ray diffraction diagram of the aripiprazole hydrate A obtained in Reference Example 4.
- Figure 4 is the X H-NMR spectrum (DMSO-d 6 , TMS) of the aripiprazole anhydride crystals B obtained in Example 1.
- Figure 5 is the powder X-ray diffraction diagram of the aripiprazole anhydride crystals B obtained in Example 1.
- Figure 6 is the thermogravimetric/differential thermogram of the aripiprazole hydrate A obtained in Reference Example 3.
- Figure 7 is the powder X-ray diffraction diagram of aripiprazole hydrate obtained in Reference Example 3.
- Figure 8 is a schematric representation of the chemical structures of aripiprazole and metabolites thereof. Some of the metabolites may be formed through other possible pathways; for example, DM-1431 could be formed by N-dealkylation of DM-1451 and DM-1459.
- the pharmaceutical composition of the present invention comprises a first ingredient comprising a carbostyril derivative active as a dopamine-serotonin system stabilizer and a second ingredient comprising a serotonin reuptake inhibitor, in a pharmaceutically acceptable carrier.
- the pharmaceutical compositions of the present invention are useful in treating mood disorders, including depression and major depressive disorder.
- the pharmaceutical composition comprises a carbostyril derivative active as a dopamine-serotonin system stabilizer.
- carbostyril derivative has activity as an agonist or partial agonist at some serotonin receptors and some dopamine receptors, preferably as an agonist or partial agonist at the serotonin 5-HT1A receptor and as an agonist or partial agonist at the dopamine D 2 receptor.
- Carbostyril derivatives are described in U.S. Patent 5,006,528 and U.S. published patent application 2002/0173513A1. In one embodiment of the present invention, the carbostyril derivatives represented by the following formula (1) are used:
- carbon-carbon bond between 3- and 4- positions in the carbostyril skeleton is a single or a double bond.
- this activity of the carbostyril derivative • is as an agonist or partial agonist at the 5-HT1A receptor and an agonist or partial agonist at the dopamine D 2 receptor subtype.
- the carbostyril derivative to be used as a first component in the present invention is aripiprazole, or a metabolic derivative thereof.
- Metabolic derivatives of aripiprazole include but are not limited to dehydroaripiprazole, also called OPC-14857.
- Other metabolic derivatives of aripiprazole include but are not limited to the chemical structures shown in Figure 8 as OPC-14857, DM-1458, DM-1451, DM-1452, DM-1454 and DCPP.
- Aripiprazole also called 7- ⁇ 4- [4- (2, 3- dichlorophenyl) -l-piperazinyl]butoxy ⁇ -3, 4-dihydro- 2 (IH) -quinolinone, is a carbostyril compound useful as the effective ingredient for treating schizophrenia (JP-A-2-191256, U S. Patent 5,006,528).
- Aripiprazole is also known as 7- [4- [4- (2, 3-dichlorophenyl) -1- piperazinyl] butoxy] -3, 4-dihydrocarbostyril, Abilify, OPC-14597, OPC-31 and BMS-337039.
- Aripiprazole possesses 5-HT1A receptor agonist activity, and is known as a useful compound for treating types of depression and refractory depression, such as endogenous depression, major depression, melancholia and the like (WO 02/060423A2; Jordan et al . U.S. Patent Application 2002/0173513A1) .
- Aripiprazole has activity as an agonist at serotonin receptors and dopamine receptors, and acts as an agonist or partial agonist at the serotonin 5-HT1A receptor and as an agonist or partial agonist at the dopamine D 2 receptor.
- Aripiprazole is an antipsychotic drug having new mechanism of action which is different from that of other atypical antipsychotic drugs (Grunder, G. et al., Arch Gen Psychiatry, 60(10), pp 974-977, 2003).
- the available typical and atypical antipsychotic drugs act as antagonists at the dopamine-D 2 receptors.
- aripiprazole acts as a partial agonist at the dopamine D 2 receptor (By Ishigooka Jyunya and Inada Ken, RINSHO SEISHIN YAKURI, Vol. 4, pp 1653-1664 (2001); Burris, K. D. et al . , J. Pharmacol. Exp. Ther., 302, pp 381-389 (2002)).
- aripiprazole has activity as a partial agonist at the serotonin 5-HT1A receptors, as well as antagonist action at serotonin 5- HT2A receptors.
- aripiprazole is a drug belonging to new category defined as a dopamine- serotonin system stabilizer (dopamine-serotonin stabilizer (Burris, K. D. et al., J. Pharmacol, Exp. Ther., 302, pp 381-389, 2002; Jordan, S. et al., Eur. J. Pharmacol. 441, pp 137-140, 2002; Grunder, G. et al., Arch Gen Psychiatry, 60(10), pp 974-977, 2003).
- dopamine-serotonin stabilizer Bopamine-serotonin stabilizer
- Aripiprazole and aripiprazole metabolites to be used in the present invention may be any of form, for example, free bases, polymorphisms of every type of crystal, hydrate, salts (acid addition salts, etc.) and the like.
- aripiprazole anhydride crystals B is a preferred form.
- method for preparing the aripiprazole anhydride crystals B for example it is prepared by heating aripiprazole hydrate A as follows.
- thermogravimetric/ differential thermal analysis heating rate 5°C/min
- thermogravimetric/ differential thermal analysis heating rate 5°C/min
- it is characterized by the appearance of a small peak at about 71 °C and a gradual endothermic peak around 60 °C to 120°C.
- It has a mean particle size of 50 ⁇ m or less .
- Aripiprazole hydrate A is prepared by milling conventional aripiprazole hydrate.
- Conventional milling methods can be used to mill conventional aripiprazole hydrate.
- conventional aripiprazole hydrate can be milled in a milling machine.
- a widely used milling machine such as an atomizer, pin mill, jet mill or ball mill can be used.
- the atomizer is preferably used.
- a rotational speed of 5000- 15000 rpm could be used for the main axis, for example, with a feed rotation of 10-30 rpm and a screen hole size of 1-5 mm.
- the mean particle size of the aripiprazole hydrate A obtained by milling may be normally 50 ⁇ m or less, preferably 30 ⁇ m or less. Mean particle size can be ascertained by the particle size measuring method described hereinafter.
- “Aripiprazole anhydride crystals B" of the present invention have the physicochemical properties given in (6) -(10) below. (6) They have an ⁇ -NMR spectrum which is substantially identical to the X H-NMR spectrum (DMSO-d 6 , TMS) shown in Figure 4.
- thermogravimetric/differential thermal analysis (heating rate 5°C/min).
- the mean particle size is preferably 50 ⁇ m or less .
- the aripiprazole anhydride crystals B of the present invention are prepared for example by heating the aforementioned aripiprazole hydrate A at 90-125 °C.
- the heating time is generally about 3-50 hours, but cannot be stated unconditionally, because it differs depending on heating temperature.
- the heating time and heating temperature are inversely related, so that for example when the heating time is longer, then the heating temperature is lower, and when the heating temperature is higher then the heating time is shorter. Specifically, if the heating temperature of aripiprazole hydrate A is 100 °C, the heating time may be 18 hours or more, or preferably about 24 hours.
- the heating time may be about 3 hours.
- the aripiprazole anhydride crystals B of the present invention can be prepared with certainty by heating aripiprazole hydrate A for about 18 hours at 100 °C, and then heating it for about 3 hours at 120 °C.
- the aripiprazole anhydride crystals B of the present invention can also be obtained if the heating time is extended still further, but this method may not be economical .
- aripiprazole anhydride crystals B can be also obtained by the following process.
- Aripiprazole anhydride crystals B of the present invention are prepared for example by heating conventional aripiprazole anhydride crystals at 90- 125 °C.
- the heating time is generally about 3-50 hours, but cannot be stated unconditionally because it differs depending on heating temperature.
- the heating time and heating temperature are inversely related, so that for example if the heating time is longer, the heating temperature is lower, and if the heating time is shorter, the heating temperature is higher. Specifically, if the heating temperature of the aripiprazole anhydride crystals is 100 °C, the heating time may be about 4 hours, and if the heating temperature is 120 °C the heating time may be about 3 hours .
- aripiprazole anhydride crystals B of the present invention are prepared for example, by heating conventional aripiprazole hydrate at 90-125° C.
- the heating time is generally about 3-50 hours, but cannot be stated unconditionally because it differs depending on heating temperature.
- the heating time and heating temperature are inversely related, so that for example, if the heating time is longer, the heating temperature is lower, and if the heating time is shorter, the heating temperature is higher.
- the heating time may be about 24 hours, and if the heating temperature is 120 °C the heating time may be about 3 hours.
- the aripiprazole anhydride crystals which are the raw material for preparing the aripiprazole anhydride crystals B of the present invention are prepared for example by Method a or b below.
- Method a Process for preparing crude crystals of Aripiprazole
- Method b Process for preparing conventional Aripiprazole Anhydride
- the aripiprazole hydrate which is the raw material for preparing the aripiprazole anhydride crystals B of the present invention is prepared for example by Method c below.
- Method c Method for preparing conventional
- Aripiprazole hydrate is easily obtained by dissolving the aripiprazole anhydride crystals obtained by Method a above in a hydrous solvent, and heating and then cooling the resulting solution. Using this method, aripiprazole hydrate is precipitated as crystals in the hydrous solvent.
- the hydrous solvent may be preferable one which is miscible with water, for example an alcohol such as methanol, ethanol, propanol or isopropanol, a ketone such as acetone, an ether such as tetrahydrofuran, dimethylformamide, or a mixture thereof, ethanol is particularly desirable.
- the amount of water in the hydrous solvent may be 10-25% by volume of the solvent, or preferably close to 20% by volume.
- Aripiprazole can easily form an acid addition salt with a pharmaceutically acceptable acid.
- a pharmaceutically acceptable acid for example, an inorganic acid, such as sulfuric acid, nitric acid, hydrochloric acid, phosphoric acid, hydrobromic acid, etc.; an organic acid such as, acetic acid, p-toluenesulfonic acid, methanesulfonic acid, oxalic acid, maleic acid, fumaric acid, malic acid, tartaric acid, citric acid, benzoic acid, succinic acid, etc. can be exemplified. Similar to aripiprazole of free forms, these acid addition salts can also be used as the active ingredient compounds in the present invention.
- the objective compound thus obtained through each one of production steps is separated from the reaction system by usual separation means, and can be further purified.
- the separation and purification means for example, distillation method, solvent extraction method, dilution method, recrystallization method, column chromatography, ion- exchange chromatography, gel chromatography, affinity chromatography, preparative thin-layer chromatography and the like can be exemplified.
- the pharmaceutical composition the second ingredient
- a serotonin reuptake inhibitor is used as the second ingredient.
- Compounds which function as serotonin reuptake inhibitors can be widely used as the serotonin reuptake inhibitors and are known to one of ordinary skill in the art.
- IC 50 value a concentration of the drug that inhibits serotonin reuptake by about 50%
- the standard pharmacological assay method is about 1000 nM or lower is preferable.
- serotonin reuptake inhibitors for example, fluvoxamine (5-methoxy-l- [4- (trifluoro- methyl) phenyl] -1-pentanone-O- (2-aminoethyl) oxime) , fluoxetine (N-methyl-3- (p-trifluoromethylphenoxy) -3- phenylpropylamine) , paroxetine (trans- (-) -3- [ (1, 3- benzodioxol-5-yloxy) methyl] -4- (4-fluorophenyl) - piperidine) , sertraline (IS-cis) -4- (3, 4- dichlorophenyl) -1,2,3, 4-tetrahydro-N-methyl-l- naphthylylamine hydrochloride) , venlafaxine, milnacipran (N, N-diethyl-2-aminomethyl-l- phenylcyclopropanecarboxy
- the serotonin reuptake inhibitor may be either in the form of a free base or a salt (an acid addition salt or the like) . Further, the serotonin reuptake inhibitor may be either a racemic modifications or R and S enantiomers.
- the serotonin reuptake inhibitors may be either a single use of one serotonin reuptake inhibitor, and in case of need, two or more of the serotonin reuptake inhibitors may be used in combina- tion. Use of one serotonin reuptake inhibitor is preferred.
- the serotonin reuptake inhibitor can easily form an acid addition salt with a pharmaceutically acceptable acid.
- a pharmaceutically acceptable acid for example, an inorganic acid, such as sulfuric acid, nitric acid, hydrochloric acid, phosphoric acid, hydrobromic acid, etc.; an organic acid such as, acetic acid, p-toluene- sulfonic acid, methanesulfonic acid, oxalic acid, maleic acid, fumaric acid, malic acid, tartaric acid, citric acid, benzoic acid, succinic acid, etc. can be exemplified. Similar to the reuptake inhibitor of free forms, these acid addition salts can be also used as the active ingredient compounds in the present invention.
- a compound having acidic group can easily form salt by reacting with a pharmaceutically acceptable basic compound.
- a pharmaceutically acceptable basic compound a metal hydroxide, for example, sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide and the like; an alkali metal carbonate or bicarbonate, for example sodium carbonate, potassium carbonate, sodium hydrogencabonate, potassium hydrogencarbonate and the like; a metal alcoholate, for example sodium methylate, potassium ethylate and the like can be exemplified.
- the thus obtained salt form of serotonin reuptake inhibitor is separated from the reaction system by usual separation means, and can be further purified.
- the separation and purification means for example, distillation method, solvent extraction method, dilution method, recrystallization method, column chromatography, ion-exchange chromatography, gel chromatography, affinity chromatography, preparative thin-layer chromatography and the like can be exemplified .
- Combination of the first ingredient with the second ingredient As to combination of carbostyril derivatives with activity as dopamine-serotonin system stabilizers, non-limiting examples of aripiprazole and dehydroaripiprazole are described herein.
- aripiprazole/fluoxetine When aripiprazole is combined with at least one serotonin reuptake inhibitor, the following are non-limiting examples of such combinations: aripiprazole/fluoxetine, aripiprazole/duloxetine, aripiprazole/venlafaxine, aripiprazole/milnacipran, aripiprazole/citalopram, aripiprazole/fluvoxamine, aripiprazole/paroxetine, and aripiprazole/sertraline.
- a preferred embodiment comprises a combination of aripiprazole/citalopram.
- aripiprazole, or a metabolite thereof may be combined with more than one serotonin reuptake inhibitor.
- Metabolites of aripiprazole that may be used in the present invention include but are not limited to OPC-14857, DM-1458, DM-1451, DM-1452, DM- 1454 and DCPP as shown in Figure 8. Any one of these metabolites may be used in the present invention.
- dehydroaripiprazole with specific serotonin reuptake inhibitors, however it is to be understood that any one of DM-1458, DM-1451, DM-1452, DM-1454 or DCPP, as shown in Figure 8, could be substituted for dehydroaripiprazole in these disclosed combinations.
- Dehydroaripiprazole also called OPC-14857 in Figure 8 is a preferred metabolite of aripiprazole.
- dehydroaripiprazole/fluoxetine dehydroaripiprazole/duloxetine, dehydroaripiprazole/venlafaxine, dehydroaripiprazole/milnacipran, dehydroaripiprazole/citalopram, dehydroaripiprazole/fluvoxamine, dehydroaripiprazole/paroxetine, and dehydroaripiprazole/sertraline.
- a preferred embodiment comprises a combination of dehydroaripiprazole and citalopram.
- compositions of the present invention Patients with mood disorders may be treated with the compositions of the present invention.
- a preferred disorder treated with the method and compositions of the present invention is depression or major depressive disorder.
- Treatment comprises administration of the compositions of the present invention to a patient with a mood disorder such as depression or major depressive disorder, in an amount and dose regimen effective to treat the mood disorder.
- Dosage of the drug used in the present invention is decided by considering the properties of each constituting drug to be combined, the properties of drugs being after combination and symptoms of the patient (existence of other diseases beside mood disorders such as depression or major depressive disorder) .
- General outlines of the dosage can be applied the following guidelines.
- Aripiprazole or a metabolite such as dehydroaripiprazole, DM-1458, DM-1451, DM-1452, DM-1454 or DCPP: generally about 0.1 to 100 mg/once a day (or about 0.05 to about 50 mg/twice a day), preferably about 1 to 30 mg/once a day (or about 0.5 to about 15 mg/twice a day) .
- aripiprazole or a metabolite thereof, may be combined with at least one of any of the following SRIs at the dosage ranges indicated:
- Fluoxetine generally about 1 to about 80 mg/once a day, preferably about 10 to about 40 mg/once a day;
- Duloxetine generally about 1 to 160 mg/once a day (or 80 mg/twice a day) , preferably about 5 to about 20 mg/once a day;
- Venlafaxine generally about 10 to 150 mg/1 to 3 times a day, preferably about 25 to 125 mg/3 times a day;
- Milnacipran generally about 10 to 100 mg/1 to 2 times a day, preferably about 25 to about 50 mg/twice a day;
- Citalopram generally about 5 to about 50 mg/once a day, preferably about 10 to about 30 mg/once a day;
- Escitalopram generally about 5 to about 30 mg/once a day, preferably about 10 to about 20 mg/once a day;
- Fluvoxamine generally about 20 to 500 mg/once a day, preferably about 50 to 300 mg/once a day;
- Paroxetine generally about 20 to about 50 mg/once a day, preferably about 20 to about 30 mg/once a day; or Sertraline: generally, about 20 to about 500 mg/once a day, preferably about 50 to about 200 mg/once a day.
- the weight ratio of the first ingredient to the second ingredient is selected in accordance with the above-mentioned guideline.
- the ratio of the first ingredient and the second ingredient if the first ingredient is about 1 part by weight of the former, the second ingredient is used about 0.01 to about 500 parts by weight, preferably about 0.1 to about 100 parts by weight.
- Pharmaceutically acceptable carriers include diluents and excipients generally used in pharmaceutical preparations, such as fillers, extenders, binders, moisturizers, disintegrators, surfactant, and lubricants.
- the pharmaceutical composition of the present invention may be formulated as an ordinary pharmaceutical preparation, for example in the form of tablets, flash melt tablets, pills, powder, liquid, suspension, emulsion, granules, capsules, suppositories or injection (liquid, suspension, etc.), troches, intranasal spray percutaneous patch and the like.
- a wide variety of carriers that are known in this field can be used.
- carriers include lactose, saccharose, sodium chloride, glucose, urea, starch, xylitol, mannitol, erythritol, sorbitol, calcium carbonate, kaolin, crystalline cellulose, silic acid and other excipients; water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, shellac, methyl cellulose, potassium phosphate, polyvinyl pyrrolidone and other binders; dried starch, sodium alginate, agar powder, laminaran powder, sodium hydrogencarbonate, calcium carbonate, polyoxyethylene sorbitan fatty acid esters, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose and other disintegrators; white sugar, stearin, cacao butter, hydrogenated oil and other disintegration inhibitors
- Tablets can also be formulated if necessary as tablets with ordinary coatings, such as sugar-coated tablets, gelatin-coated tablets, enteric coated tablets and film coated tablets, as well as double tablets and multilayered tablets.
- ordinary coatings such as sugar-coated tablets, gelatin-coated tablets, enteric coated tablets and film coated tablets, as well as double tablets and multilayered tablets.
- carriers that are known in this field can be used. Examples include glucose, lactose, starch, cacao butter, hardened vegetable oil, kaolin, talc and other excipients; gum arabic powder, traganth powder, gelatin, ethanol and other binders; and laminaran, agar and other disintegrators and the like.
- a wide variety of carriers that are known in the field can be used. Examples include polyethylene glycol, cacao butter, higher alcohol, esters of higher alcohol, gelatin semi-synthetic glyceride and the like.
- Capsules are prepared according to ordinary methods by mixing carbostyril derivatives such as aripiprazole anhydride crystals as the first ingredient and serotonin reuptake inhibitor as the second ingredient, and the various carriers described above and packing them in hard gelatin capsules, soft capsules hydroxypropylmethyl cellulose capsules (HPMC capsules) and the like.
- carbostyril derivatives such as aripiprazole anhydride crystals
- serotonin reuptake inhibitor as the second ingredient
- colorants preservatives, perfumes, flavorings, sweeteners and the like as well as other drugs may be contained in the pharmaceutical composition.
- the amounts of the first ingredient and the second ingredient to be contained in the pharmaceutical composition of the present invention are suitably selected from a wide range depending on the diseases to be treated. Generally, about 1 to 70 parts by weight, preferably about 1 to 30 parts by weight of the first ingredient and the second ingredient in the total amount on the basis of the pharmaceutical composition.
- the methods for administration of the pharmaceutical composition of the present invention are not specifically restricted.
- the composition is administered depending on each type of preparation forms, and the age, gender and other condition of the patient (degree and conditions of the disease, etc.) . For example, tablets, pills, liquids, suspensions, emulsions, granules and capsules are administered orally.
- injection preparation it is administered intravenously by either singly or mixed with a common auxiliary liquid such as solutions of glucose or amino acid. Further, if necessary, the injection preparation is singly administered intracutaneously, subcutaneously or intraperitoneally. In case of a suppository, it is administered intrarectally.
- Administration forms of the pharmaceutical composition of the present invention may be any type by which the effective levels of both carbostyril derivatives and serotonin reuptake inhibitors can be provide in vivo at the same time.
- a carbostyril derivative together with a serotonin reuptake inhibitor are contained in one pharmaceutical composition and this composition may be administered.
- each one of carbostyril derivative and a serotonin reuptake inhibitor are contained individually in a pharmaceutical preparation respectively, and each one of these preparations may be administered at the same time or in suitable intervals.
- Dosage of the pharmaceutical composition of the present invention for treating and improving depression or major depressive disorder may be used relatively in a small amount, because the composition possesses excellent efficacy. Therefore the composition has fewer side-effects and an excellent safety profile.
- the pharmaceutical composition of the present invention is quite effective for treating or improving mood disorders such as depressive symptoms, depression, refractory depression, major depressive disorder and the like.
- composition of the present invention can be manifest in a wide range of neurotransmission accommodation actions.
- the composition of the present invention establishes pseudo-homeostatic dopaminergic and serotoninergic neurotransmission (as a result of partial agonism) , which, as a result of neuropathophysiological processes has ceased to function normally.
- the mood disorders which can be treated by the pharmaceutical composition of the present invention includes the mood disorders being classified in "Diagnostic and Statistical Manual of Mental Disorders” Fourth Edition (DSM-IV) published by the American Psychiatric Association. These mood disorders include, for example, major depressive disorder, all mood disorders, schizoaffective disorder, dementia with depressive symptoms and the like. A preferred disorder to be treated with the present invention is major depressive disorder.
- the pharmaceutical composition of the present invention is useful for treating major depressive disorder, endogenous depression, melancholia, depression in combination with psychotic episodes, bipolar disorder with depressive phase, refractory depression, dementia of the Alzheimer's type with depressive symptoms, Parkinson's disease with depressive symptom, senile dementia, mood disorder associated with cerebral blood vessels and mood disorder following head injury and the like.
- additional disclosure for designing clinical studies is provided in J. Clin. Psychiatry, 2002, 63: (12), pp 1164-1170; J. Clin. Psychiatry, 2002, 63: (8), pp 733- 736; and J. Clin. Psychiatry, 2002, 63: (5), pp 391-395.
- the powder x-ray diffraction pattern was measured at room temperature by using a Cu Ka filled tube (35 kV 20mA) as the x-ray source with a wide-angle goniometer, a 1° scattering slit, an 0.15 mm light-intercepting slit, a graphite secondary monochromator and a scintillation counter. Data collection was done in 2 ⁇ -continuous scan mode at a scan speed of 5° /minute in scan steps of 0.02° in the range of 3° to 40°.
- Thermogravimetric/differential thermal analysis was measured by using SSC 5200 control unit and TG/DTA 220 simultaneous differential thermal/ thermogravimetric measuring unit manufactured by Seiko Corp. Samples (5 - 10 mg) were placed in open aluminum pans and heated at from 20 °C to 200 °C in a dry nitrogen atmosphere at a heating rate of 5°C/minute. -Alumina was used as the standard substance.
- the particles (0.1 g) to be measured were suspended in a 20 ml n-hexane solution of 0.5 g soy lecithin, and particle size was manufactured by using a size distribution measuring meter (Microtrack HRA, manufactured by Microtrack Co.) .
- the resulting crystals were dried at 60 °C for 14 hours to obtain 20.4 g (74.2%) of crude product of aripiprazole.
- the crude product of aripiprazole (30 g) obtained above was recrystallized from 450 ml of ethanol according to the methods described in Japanese Unexamined Patent Publication No. 191256/1990, and the resulting crystals were dried at 80°C for 40 hours to obtain aripiprazole anhydride crystals.
- the yield was 29.4 g (98.0%) .
- the melting point (mp) of these aripiprazole anhydride crystals was 140 °C, which is identical to the melting point of the aripiprazole anhydride crystals described in Japanese Unexamined Patent Publication No. 191256/1990.
- the crude product of aripiprazole (6930 g) obtained in Reference Example 1 was heat dissolved by heating in 138 liters of hydrous ethanol (water content 20% by volume) according to the method presented at the 4th Joint Japanese-Korean Symposium on Separation Technology, the solution was gradually (2-3 hours) cooled to room temperature, and then was chilled to near 0°C.
- the precipitated crystals were collected by filtration, about 7200 g of aripiprazole hydrate (wet- state) .
- the wet-state aripiprazole hydrate crystals obtained above were dried at 80 °C for 30 hours to obtain 6480 g (93.5%) of aripiprazole anhydride crystals.
- the melting point (mp) of these crystals was 139.5°C.
- the water content of the crystals were confirmed by the Karl Fischer method, the moisture value was 0.03%, thus the crystals were confirmed as anhydrous product.
- the aripiprazole hydrate (820 g) in wet state obtained from Reference Example 2 was dried at 50 °C for 2 hours to obtain 780 g of aripiprazole hydrate crystals.
- the moisture value of the crystals had a moisture value was 3.82% measured according to the Karl
- thermogravimetric/differential thermal analysis revealed endothermic peaks at 75.0, 123.5 and 140.5°C.
- the powder x-ray diffraction spectrum of this aripiprazole hydrate was identical to the powder x-ray diffraction spectrum of aripiprazole hydrate presented at the 4th Joint Japanese-Korean Symposium on Isolation Technology.
- the aripiprazole hydrate crystals (500.3 g) obtained in Reference Example 3 were milled by using a sample mill (small size atomizer) .
- the main axis rotation rate was set to 12,000 rpm and the feed rotation rate to 17 rpm, and a 1.0 mm herringbone screen was used. Milling was finished in 3 minutes, and obtained 474.6 g (94.9%) of powder of aripiprazole hydrate A.
- the aripiprazole hydrate A (powder) obtained in this way had a mean particle size of 20-25 ⁇ m.
- the melting point .(mp) was undetermined because dehydration was observed beginning near at 70 °C.
- the aripiprazole hydrate A (powder) obtained above had infrared absorption bands at 2951, 2822, 1692, 1577, 1447, 1378, 1187, 963 and 784 cm -1 on the IR (KBr) spectrum.
- the aripiprazole hydrate A (powder) obtained above had a weak peak at 71.3°C in thermogravimetric/differential thermal analysis and a broad endothermic peak (weight loss observed corresponding to one molecule of water) between 60-120 °C which was clearly different from the endothermic curve of unmilled aripiprazole hydrate (see Figure 6) .
- the aripiprazole hydrate A (powder) (44.29 kg) obtained in the Reference Example 4 was dried at 100 °C for 18 hours by using a hot air dryer and further heated at 120 °C for 3 hours, to obtain 42.46 kg (yield; 99.3 %) of aripiprazole anhydride crystals B.
- These aripiprazole anhydride crystals B had a melting point (mp) of 139.7°C.
- the aripiprazole anhydride crystals B obtained above had remarkable infrared absorption bands at 2945, 2812, 1678, 1627, 1448, 1377, 1173, 960 and 779 cm -1 on the IR (KBr) spectrum.
- the aripiprazole anhydride crystals B obtained above exhibited an endothermic peak near about at 141.5 °C in thermogravimetric/differential thermal analysis.
- the aripiprazole anhydride crystals B obtained above exhibited an endothermic peak near about at 140.7 °C in differential scanning calorimetry.
- Serotonin (5-HT) and WAY-100635 N-[2- [4- (2- methoxyphenyl) -1-piperazinyl] ethyl] -N- (2-pyridyl) - cyclohexanecarboxamide, a 5-HT1A receptor antagonist, manufactured by RBI (Natick, Mass.) were used as reference compounds .
- DMSO Dimethyl sulfoxide
- Test compound was dissolved in 100% dimethyl sulfoxide (DMSO) to yield 100 ⁇ M stock solutions (final concentration of DMSO in all tubes containing test compound was 1%, v/v) . All other reference compounds were prepared by the same method using double-distilled water rather than DMSO.
- DMSO dimethyl sulfoxide
- Serotonin (5-HT) is a full 5-HT1A receptor agonist which stimulates increases in basal [ 35 S]GTP ⁇ S binding to h5-HTlA receptors in recombinant CHO cell membranes.
- the test compound was studied at 10 concentrations to determine effects upon basal [ 35 S]GTP ⁇ S binding relative to that produced by 10 ⁇ M 5-HT.
- the relative potency (EC 50 , 95% confidence interval) and intrinsic agonist activity (% of E max for 10 ⁇ M 5-HT) was calculated for each compound by computerized non-linear regression analysis of complete concentration-effect data.
- test compound at the h5- HT1A receptor was determined by its ability to prevent [ 3 H] 8-OH-DPAT binding to CHO cell membranes that express this receptor.
- Non-linear regression analysis of the competition binding data was used to calculate an inhibition constant (IC 50 , 95% confidence interval) , which is the concentration of test compound that occupies half of the h5-HTlA sites specifically bound by [ 3 H] 8-OH-DPAT.
- test compound and 5-HT produced concentration-dependent increases above basal [ 35 S]GTP ? S binding.
- Potency and intrinsic agonist efficacy estimates were derived by non-linear regression analysis with correla- tion coefficients (r 2 )>0.98 in each case (Table 1).
- the test compound exerted partial agonist efficacies in the 65 - 70% range.
- WAY-100635 produced no significant change (unpaired Student's t-test) in basal [ 35 S]GTP ⁇ S binding at all concentrations tested (Table 1) .
- WAY- 100635 did, however, completely inhibit the effects of 5-HT and test compound upon [ 35 S]GTP ⁇ S binding to h5-HTlA receptors in CHO cell membranes (Table 2) . Tables 1 and 2 are shown below.
- the forced swimming test proposed by Porsolt et al. (Porsolt, R. D. et al.: Arch. Int. Pharmacodyn. , 229, 327-336, 1977) is widely used as to an experimental animal model for predicting the antidepressant activity in clinical settings.
- a test mouse is put in a cylinder in which a suitable amount of water is contained, and the antidepressant action of a test drug is detected by measuring the immobility time, as the indication, shown by the mouse. It was reported that the action of shortening the immobility time is correlated with clinically observed antidepressive action (Willner, P.: Psychopharmacology, 83: 1-16, 1984) .
- the crisis of depression is closely concerned with lowering of serotonin 5-HT1A receptor neurotransmission action, and the present inventors have found the facts that antidepressive action of antidepressants which affect to serotonin system can be detected more precisely using prolongation of the immobility time performed with WAY-100635, which is a selective serotonin 5-HT1A receptor antagonist.
- the prolongation of the immobility time performed by WAY-100635 is defined as the indication.
- the antidepressive action of test antidepressants was determined by taking the prolongation of immobility time performed by WAY- 100635 in the forced swimming test as the indication.
- a mouse of ICR strain is placed in the cylinder. After placing the mouse in the cylinder, an immobility time of 6 minutes is measured. During the test, the water temperature is maintained at 23 to 24 °C. A test drug is orally administered to the mouse at 1 or 2 hours before placing the mouse in the water. WAY-100635 is administered subcutaneously to the mouse 30 minutes before placing the mouse in the water.
- aripiprazole is used in combination together with citalopram, escitalopram, fluoxetine, venlafaxine or milnacipran.
- a decrease in the immobility time is observed in comparison with the case of single use of each one of aripiprazole, citalopram, escitalopram, fluoxetine, venlafaxine or milnacipran, respectively.
- aripiprazole when used in combination with citalopram, escitalopram, fluoxetine, venlafaxine or milnacipran, a decrease in the immobility time (the antidepressant activity) is observed in comparison to administration of the available atypical antipsychotic drugs such as olanzapine, quetiapine, risperidone in combination with citalopram, fluoxetine, venlafaxine or milnacipran.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned fomuration was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- the tablet containing the above mentioned formulation was prepared.
- Aripiprazole is evaluated as an augmentation therapy in depressed patients with major depressive disorder who were previously non-responsive or partially responsive to anti-depressant medication comprising serotonin reuptake inhibitors. These patients currently receive therapy through administration of serotonin reuptake inhibitors.
- Aripiprazole is first administered at a dose of 10 mg/day and increased to 30 mg/day as needed in the opinion of the monitoring psychiatrist. Aripiprazole is administered to these patients at a dose of from 10 mg/day to 30 mg/day for a period of at least four weeks, and up to eight weeks for patients who respond well to this treatment during the first four weeks.
- CGI clinical global impression
- AIMS abnormal involuntary movement scale
- SAS Simpson Angus scale
- Barnes Barnes akathesia scale
- a combination of aripiprazole and at least one serotonin reuptake inhibitor is evaluated as a therapy for depression in patients newly diagnosed with major depressive disorder. Patients ranging in age from 18 to 65 years who are diagnosed with major depressive disorder are evaluated to ensure that they have a baseline Hamilton score for depression (item 17) of 14 or higher. Only patients with this Hamilton score receive treatment. These patients are interviewed to obtain a complete medical and psychiatric history. Aripiprazole is first administered at a dose of 10 mg/day and increased to 30 mg/day as needed in the opinion of the monitoring psychiatrist.
- Aripiprazole is administered to these patients at a dose of from 10 mg/day to 30 mg/day for a period of at least four weeks, and up to eight weeks for patients who respond well to this treatment during the first four weeks.
- the aripiprazole is administered together with at least one serotonin reuptake inhibitor, wherein the serotonin reuptake inhibitor is fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine or sertraline.
- the dosages to be used for these serotonin reuptake inhibitors are provided elsewhere in this patent application.
- the aripiprazole can be administered in one dosage form, for example a tablet, and the serotonin reuptake inhibitor may be administered in a separate one dosage form, for example a tablet.
- the administration may occur at about the same time or at different times during the day.
- a dosage form containing aripiprazole in combination with at least one serotonin reuptake inhibitor may be administered.
- Such combinations include without limitation the following: aripiprazole/fluoxetine, aripiprazole/duloxetine, aripiprazole/venlafaxine, aripiprazole/milnacipran, aripiprazole/citalopram, aripiprazole/fluvoxamine, aripiprazole/paroxetine, and aripiprazole/sertraline.
- a preferred embodiment comprises a combination of aripiprazole and citalopram.
- Example 7 Method of Treatment of Patients Diagnosed with Major Depressive Disorder Who Were Previously Non-responsive or Partially Responsive to Anti-depressant Medication
- Dehydroaripiprazole an active metabolite of aripiprazole, is evaluated as an augmentation therapy in depressed patients with major depressive disorder who were previously non-responsive or partially responsive to anti-depressant medication comprising serotonin reuptake inhibitors. These patients currently receive therapy through administration of serotonin reuptake inhibitors.
- Dehydroaripiprazole is first administered at a dose of 10 mg/day and increased to 30 mg/day as needed in the opinion of the monitoring psychiatrist. Dehydroaripiprazole is administered to these patients at a dose of from 10 mg/day to 30 mg/day for a period of at least four weeks, and up to eight weeks for patients who respond well to this treatment during the first four weeks .
- CGI clinical global impression
- AIMS abnormal involuntary movement scale
- SAS Simpson Angus scale
- BARS Barnes akathesia rating scale
- a combination of dehydroaripiprazole and at least one serotonin reuptake inhibitor is evaluated as a therapy for depression in patients newly diagnosed with major depressive disorder. Patients ranging in age from 18 to 65 years who are diagnosed with major depressive disorder are evaluated to ensure that they have a baseline Hamilton score for depression (item 17) of 14 or higher. Only patients with this Hamilton score receive treatment. These patients are interviewed to obtain a complete medical and psychiatric history. Dehydroaripiprazole is first administered at a dose of 10 mg/day and increased to 30 mg/day as needed in the opinion of the monitoring psychiatrist.
- Dehydroaripiprazole is administered to these patients at a dose of from 10 mg/day to 30 mg/day for a period of at least four weeks, and up to eight weeks for patients who respond well to this treatment during the first four weeks.
- the dehydroaripiprazole is administered together with at least one serotonin reuptake inhibitor, wherein the serotonin reuptake inhibitor is fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine or sertraline.
- the dehydroaripiprazole can be administered in one dosage form, for example a tablet, and the serotonin reuptake inhibitor may be administered in a separate one dosage form, for example a tablet.
- the administration may occur at about the same time or at different times during the day.
- a dosage form containing dehydroaripiprazole in combination with at least one serotonin reuptake inhibitor may be administered.
- Such combinations include without limitation the following: dehydroaripiprazole/fluoxetine, dehydroaripiprazole/duloxetine, dehydroaripiprazole/venlafaxine, dehydroaripiprazole/milnacipran, dehydroaripiprazole/citalopram, dehydroaripiprazole/fluvoxamine, dehydroaripiprazole/paroxetine, and dehydroaripiprazole/sertraline.
- a preferred embodiment comprises a combination of dehydroaripiprazole and citalopram.
- the tail suspension test was originally described by Steru et al . (1985). 1) A mouse suspended by its tail shows periods of agitation and immobility. The antidepressant activity of a test drug can be detected as an index of shortening the immobility time. This test is widely used as to an experimental animal model for predicting the antidepressant activity of a test drug in clinical settings. An automated device for performing the TST was developed by the authors of the TST (1989). 2) We improved this device and developed our own device incorporating an electric balance, an A/D converter, a testing box (30x25x25 cm) , and a personal computer. The mouse was suspended from a hook hanging from the ceiling in the testing box by adhesive tape applied 20 mm from the tip of the tail. The duration of immobility was measured by the computer for a period of 15 min following the start of suspension. The immobility time for a period of 10 min (5-15 min) was evaluated. The experiments were carried out in a sound-proof room.
- Aripiprazole was suspended in 0.5% gum arabic-0.9% saline solution and citalopram was dissolved in 0.9% saline solution.
- Aripiprazole (3 mg/kg) and citalopram (3 mg/kg) were orally administered to mice 60 min before the start of suspension.
- the decrease in the immobility time of the combination of aripiprazole with citalopram was statistically significant synergistic effect in comparison with the effects of aripiprazole- and citaroplam-treated groups (Table 3) .
- N 7-9, **p ⁇ 0.01 vs. vehicle group (two-tailed t-test) , ##p ⁇ 0.01 vs. aripiprazole alone (two-tailed t-test), $p ⁇ 0.05 vs. citalopram alone (two-tailed t-test).
- the decrease in the immobility time of the combination of aripiprazole with citalopram was a statistically significant synergistic effect in comparison with the effects of aripiprazole- and citaroplam-treated groups (p ⁇ 0.05, one-way ANOVA) .
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US15/176,464 US9694009B2 (en) | 2002-12-27 | 2016-06-08 | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
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US16/242,315 US20190151308A1 (en) | 2002-12-27 | 2019-01-08 | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
US16/664,984 US20200289501A1 (en) | 2002-12-27 | 2019-10-28 | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
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