WO2004058189A3 - Chemokine antagonists and uses thereof - Google Patents

Chemokine antagonists and uses thereof Download PDF

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Publication number
WO2004058189A3
WO2004058189A3 PCT/US2003/041363 US0341363W WO2004058189A3 WO 2004058189 A3 WO2004058189 A3 WO 2004058189A3 US 0341363 W US0341363 W US 0341363W WO 2004058189 A3 WO2004058189 A3 WO 2004058189A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemokine
terminal domain
pharmaceutical compositions
present
antagonist
Prior art date
Application number
PCT/US2003/041363
Other languages
French (fr)
Other versions
WO2004058189A2 (en
Inventor
Javier V Navarro
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority to AU2003300396A priority Critical patent/AU2003300396A1/en
Priority to EP03814396A priority patent/EP1578381A2/en
Publication of WO2004058189A2 publication Critical patent/WO2004058189A2/en
Publication of WO2004058189A3 publication Critical patent/WO2004058189A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a chemokine peptide antagonist comprising the N-terminal domain of a CXCR1 receptor. The native amino acid(s) of such N-terminal domain is replaced by one or more histidine residues, thereby forming Zn(II) binding site(s) in said N-terminal domain. The antagonist specifically binds a chemokine in the presence of Zn(II), thereby neutralizing the action of the chemokine. Representative examples of chemokine peptide antagonist effective against IL-8 are disclosed herein. Also provided are pharmaceutical compositions containing the chemokine peptide antagonists of the present invention and methods of using such pharmaceutical compositions.
PCT/US2003/041363 2002-12-24 2003-12-23 Chemokine antagonists and uses thereof WO2004058189A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003300396A AU2003300396A1 (en) 2002-12-24 2003-12-23 Chemokine antagonists and uses thereof
EP03814396A EP1578381A2 (en) 2002-12-24 2003-12-23 Chemokine antagonists and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43625302P 2002-12-24 2002-12-24
US60/436,253 2002-12-24

Publications (2)

Publication Number Publication Date
WO2004058189A2 WO2004058189A2 (en) 2004-07-15
WO2004058189A3 true WO2004058189A3 (en) 2007-04-19

Family

ID=32682364

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041363 WO2004058189A2 (en) 2002-12-24 2003-12-23 Chemokine antagonists and uses thereof

Country Status (4)

Country Link
US (1) US20040152634A1 (en)
EP (1) EP1578381A2 (en)
AU (1) AU2003300396A1 (en)
WO (1) WO2004058189A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060084184A1 (en) * 2004-10-19 2006-04-20 Renovar Incorporated Reagents for urine-based immunological assays
EP1894571A1 (en) * 2006-08-29 2008-03-05 Protaffin Biotechnologie AG Use of modified interleukin-8 proteins for treating reperfusion injury or transplant rejection
US20100197588A1 (en) * 2007-09-11 2010-08-05 Dorian Bevec Use of a peptide as a therapeutic agent
ATE522225T1 (en) * 2007-09-11 2011-09-15 Mondobiotech Lab Ag USE OF THE PEPTIDE PHPFHLFVY (RENIN INHIBITOR) IN ANTI-ANGIOGENIC THERAPY OF CERTAIN DISEASES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018641A1 (en) * 1991-04-10 1992-10-29 The Trustees Of Boston University Interleukin-8 receptors and related molecules and methods
US5374506A (en) * 1991-09-13 1994-12-20 The United States Of America As Represented By The Department Of Health And Human Services Amino acid sequence for a functional human interleukin-8 receptor
WO1995025126A1 (en) * 1994-03-15 1995-09-21 Repligen Corporation Antibodies to interleukin-8 receptors and methods of use
US20020197706A1 (en) * 1998-07-28 2002-12-26 Cadus Pharmaceutical Corporation Expression of g protein-coupled receptors with altered ligand binding and/or coupling properties

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018641A1 (en) * 1991-04-10 1992-10-29 The Trustees Of Boston University Interleukin-8 receptors and related molecules and methods
US5374506A (en) * 1991-09-13 1994-12-20 The United States Of America As Represented By The Department Of Health And Human Services Amino acid sequence for a functional human interleukin-8 receptor
WO1995025126A1 (en) * 1994-03-15 1995-09-21 Repligen Corporation Antibodies to interleukin-8 receptors and methods of use
US20020197706A1 (en) * 1998-07-28 2002-12-26 Cadus Pharmaceutical Corporation Expression of g protein-coupled receptors with altered ligand binding and/or coupling properties

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BECKMAN M.P. ET AL.: "Molecular characterization of the interleukin-8 receptor", BIOCHEM. BIOPHYS. RES. COMM., vol. 179, 1991, pages 784 - 789, XP002976715 *
LEE J. ET AL.: "Characterization of complementary DNA clones encoding the rabbit IL-8 receptor", J. IMMUNOL., vol. 148, 1992, pages 1261 - 1264, XP003010635 *
THOMAS K.M. ET AL.: "Molecular cloning of the fMet-Leu-Phe receptor from neutrophils", J. BIOL. CHEM., vol. 265, 1990, pages 20061 - 20064, XP002976714 *

Also Published As

Publication number Publication date
AU2003300396A1 (en) 2004-07-22
EP1578381A2 (en) 2005-09-28
AU2003300396A8 (en) 2004-07-22
US20040152634A1 (en) 2004-08-05
WO2004058189A2 (en) 2004-07-15

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