WO2004058088A3 - Bacteriophage-encoded antibacterial enzyme for the treatment and prevention of gingivitis and root surface caries - Google Patents

Bacteriophage-encoded antibacterial enzyme for the treatment and prevention of gingivitis and root surface caries Download PDF

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Publication number
WO2004058088A3
WO2004058088A3 PCT/US2003/041158 US0341158W WO2004058088A3 WO 2004058088 A3 WO2004058088 A3 WO 2004058088A3 US 0341158 W US0341158 W US 0341158W WO 2004058088 A3 WO2004058088 A3 WO 2004058088A3
Authority
WO
WIPO (PCT)
Prior art keywords
gingivitis
bacteriophage
prevention
treatment
encoded
Prior art date
Application number
PCT/US2003/041158
Other languages
French (fr)
Other versions
WO2004058088A2 (en
WO2004058088A8 (en
Inventor
Allan L Delisle
Gerard J Barcak
Ming Guo
Original Assignee
Univ Maryland
Allan L Delisle
Gerard J Barcak
Ming Guo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland, Allan L Delisle, Gerard J Barcak, Ming Guo filed Critical Univ Maryland
Priority to AU2003297522A priority Critical patent/AU2003297522A1/en
Publication of WO2004058088A2 publication Critical patent/WO2004058088A2/en
Publication of WO2004058088A3 publication Critical patent/WO2004058088A3/en
Publication of WO2004058088A8 publication Critical patent/WO2004058088A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method and composition for the treatment and prevention of gingivitis and root surface caries using Actinomyces naeslundii bacteriophage Av-1 encoded anti-bacterial enzyme (Av-1 lysin) to remove and inhibit establishment of cariogenic and pathogenic bacteria in the oral cavity is disclosed, along with the amino acid sequence of the enzyme used therein and the isolated DNA molecule encoding the same.
PCT/US2003/041158 2002-12-23 2003-12-23 Bacteriophage-encoded antibacterial enzyme for the treatment and prevention of gingivitis and root surface caries WO2004058088A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003297522A AU2003297522A1 (en) 2002-12-23 2003-12-23 Bacteriophage-encoded antibacterial enzyme for the treatment and prevention of gingivitis and root surface caries

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43530102P 2002-12-23 2002-12-23
US60/435.301 2002-12-23

Publications (3)

Publication Number Publication Date
WO2004058088A2 WO2004058088A2 (en) 2004-07-15
WO2004058088A3 true WO2004058088A3 (en) 2006-10-12
WO2004058088A8 WO2004058088A8 (en) 2007-02-01

Family

ID=32682214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041158 WO2004058088A2 (en) 2002-12-23 2003-12-23 Bacteriophage-encoded antibacterial enzyme for the treatment and prevention of gingivitis and root surface caries

Country Status (2)

Country Link
AU (1) AU2003297522A1 (en)
WO (1) WO2004058088A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013106455A1 (en) 2013-06-20 2014-12-24 Airbus Defence and Space GmbH Method for decontamination of bacteriological contaminants

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231857B1 (en) * 1998-09-28 2001-05-15 The Regents Of The University Of California Antibodies to S. mutans and uses thereof
US6238661B1 (en) * 1997-10-31 2001-05-29 New Horizons Diagnostics Corp. Use of bacterial phage associated lysing enzymes for treating various illnesses
US20010014463A1 (en) * 1994-09-09 2001-08-16 Allan L. Delisle Method for the treatment and the prevention of dental caries and peridontal diseases using bacterio phage-encoded enzymes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010014463A1 (en) * 1994-09-09 2001-08-16 Allan L. Delisle Method for the treatment and the prevention of dental caries and peridontal diseases using bacterio phage-encoded enzymes
US6238661B1 (en) * 1997-10-31 2001-05-29 New Horizons Diagnostics Corp. Use of bacterial phage associated lysing enzymes for treating various illnesses
US6231857B1 (en) * 1998-09-28 2001-05-15 The Regents Of The University Of California Antibodies to S. mutans and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DELISLE A.L. ET AL: "Isolation and Expression of the Lysis Genes of Actinomyces naeslundii Phage Av-1", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 72, no. 2, February 2006 (2006-02-01), pages 1110 - 1117, XP003004207 *

Also Published As

Publication number Publication date
AU2003297522A8 (en) 2004-07-22
AU2003297522A1 (en) 2004-07-22
WO2004058088A2 (en) 2004-07-15
WO2004058088A8 (en) 2007-02-01

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