WO2004056982A3 - Kinase sequences - Google Patents

Kinase sequences Download PDF

Info

Publication number
WO2004056982A3
WO2004056982A3 PCT/EP2003/014674 EP0314674W WO2004056982A3 WO 2004056982 A3 WO2004056982 A3 WO 2004056982A3 EP 0314674 W EP0314674 W EP 0314674W WO 2004056982 A3 WO2004056982 A3 WO 2004056982A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
acid sequences
relates
sequences
nucleotide
Prior art date
Application number
PCT/EP2003/014674
Other languages
French (fr)
Other versions
WO2004056982A2 (en
Inventor
Wilde Gert Jules Hector De
Original Assignee
Devgen Nv
Wilde Gert Jules Hector De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0230014A external-priority patent/GB2396615A/en
Application filed by Devgen Nv, Wilde Gert Jules Hector De filed Critical Devgen Nv
Priority to AU2003296696A priority Critical patent/AU2003296696A1/en
Priority to EP03813586A priority patent/EP1597361A2/en
Priority to US10/540,634 priority patent/US20060275767A1/en
Publication of WO2004056982A2 publication Critical patent/WO2004056982A2/en
Publication of WO2004056982A3 publication Critical patent/WO2004056982A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to nucleotide sequences that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds with activity as pharmaceuticals, in particular of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences - such as proteins and polypeptides - that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly the amino acid sequences of J1K, PSK, TAO1 and Q9P2I6. The invention also relates to various uses and modulators of, and methods incorporating, the nucleotide and amino acid sequences of the invention.
PCT/EP2003/014674 2002-12-23 2003-12-19 Kinase sequences WO2004056982A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003296696A AU2003296696A1 (en) 2002-12-23 2003-12-19 Kinase sequences
EP03813586A EP1597361A2 (en) 2002-12-23 2003-12-19 Kinase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases and nucleotide sequences encoding such kinase sequences
US10/540,634 US20060275767A1 (en) 2002-12-23 2003-12-19 Kinase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases and nucleotide sequences encoding such kinase sequences

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43638002P 2002-12-23 2002-12-23
GB0230014A GB2396615A (en) 2002-12-23 2002-12-23 Kinase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases
US60/436,380 2002-12-23
GB0230014.3 2002-12-23

Publications (2)

Publication Number Publication Date
WO2004056982A2 WO2004056982A2 (en) 2004-07-08
WO2004056982A3 true WO2004056982A3 (en) 2004-09-16

Family

ID=32683986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/014674 WO2004056982A2 (en) 2002-12-23 2003-12-19 Kinase sequences

Country Status (3)

Country Link
EP (1) EP1597361A2 (en)
AU (1) AU2003296696A1 (en)
WO (1) WO2004056982A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053036A2 (en) * 1998-04-14 1999-10-21 Sugen, Inc. Ste20-related protein kinases
WO2000001846A2 (en) * 1998-07-03 2000-01-13 Devgen N.V. Characterisation of gene function using double stranded rna inhibition
US6034228A (en) * 1998-12-15 2000-03-07 Zeneca Limited Human signal transduction serine/threonine kinase
WO2003051905A2 (en) * 2001-12-13 2003-06-26 Exelixis, Inc. Taojiks as modifiers of the beta-catenin pathway and methods of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053036A2 (en) * 1998-04-14 1999-10-21 Sugen, Inc. Ste20-related protein kinases
WO2000001846A2 (en) * 1998-07-03 2000-01-13 Devgen N.V. Characterisation of gene function using double stranded rna inhibition
US6034228A (en) * 1998-12-15 2000-03-07 Zeneca Limited Human signal transduction serine/threonine kinase
WO2003051905A2 (en) * 2001-12-13 2003-06-26 Exelixis, Inc. Taojiks as modifiers of the beta-catenin pathway and methods of use

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BERMAN K S ET AL: "kin-18, a C. elegans protein kinase involved in feeding", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 279, no. 2, 28 November 2001 (2001-11-28), pages 137 - 147, XP004329111, ISSN: 0378-1119 *
DATABASE EMBL [online] 14 March 2000 (2000-03-14), NAGASE T. ET AL.,: "Homo sapiens mRNA for KIAA1361 protein, partial cds.", XP002285654, Database accession no. AB037782 *
DATABASE EMBL [online] 15 October 2001 (2001-10-15), JENKINS SG, ET AL.,: "Homo sapiens serine/threonine kinase TAO1 mRNA, complete cds.", XP002285653, Database accession no. AY049015 *
DATABASE EMBL [online] 16 September 1995 (1995-09-16), WILSON R. ET AL.: "Caenorhabditis elegans putative serine/threonine protein kinase (Sulu) mRNA, complete cds.", XP002285648, Database accession no. U32275 *
DATABASE EMBL [online] 19 January 2000 (2000-01-19), CARTER T.G. ET AL.: "Homo sapiens serine/threonine kinase (KDS) mRNA, complete cds.", XP002285650, Database accession no. AF181985 *
DATABASE EMBL [online] 9 February 1999 (1999-02-09), NAGASE T. ET AL.,: "Homo sapiens mRNA for KIAA0881 protein, partial cds.", XP002285652, Database accession no. AB020688 *
DATABASE GENESEQ [online] 8 February 2001 (2001-02-08), SHIMKETS RA, LEACH M: "Human ORFX ORF1427 polypeptide sequence SEQ ID NO:2854", XP002285651, Database accession no. AAB41663 *
DATABASE UNIPROT [online] 1 November 1995 (1995-11-01), COPE M.J.T.V., KENDRICK-JONES A.: "Serine/threonine-protein kinase SULU (EC 2.7.1.37).", XP002285649, Database accession no. P46549 *
HIROSUMI JIRO ET AL: "A central role for JNK in obesity and insulin resistance.", NATURE (LONDON), vol. 420, no. 6913, 21 November 2002 (2002-11-21), pages 333 - 336, XP002285647, ISSN: 0028-0836 (ISSN print) *
MOORE TANYA M ET AL: "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 6, 11 February 2000 (2000-02-11), pages 4311 - 4322, XP002285646, ISSN: 0021-9258 *
OGG S ET AL: "THE FORK HEAD TRANSCRIPTION FACTOR DAF-16 TRANSDUCES INSULIN-LIKE METABOLIC AND LONGEVITY SIGNALS IN C. ELEGANS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 389, 30 October 1997 (1997-10-30), pages 994 - 999, XP002926981, ISSN: 0028-0836 *
TASSI E ET AL: "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 47, 19 November 1999 (1999-11-19), pages 33287 - 33295, XP002965003, ISSN: 0021-9258 *
ZHANG WEIPING ET AL: "Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 274, no. 3, 11 August 2000 (2000-08-11), pages 872 - 879, XP002285645, ISSN: 0006-291X *

Also Published As

Publication number Publication date
EP1597361A2 (en) 2005-11-23
WO2004056982A2 (en) 2004-07-08
AU2003296696A1 (en) 2004-07-14
AU2003296696A8 (en) 2004-07-14

Similar Documents

Publication Publication Date Title
WO2003059934A3 (en) Albumin fusion proteins
WO2007021494A3 (en) Albumin fusion proteins
WO2008033413A3 (en) Albumin fusion proteins
WO2007146038A3 (en) Albumin fusion proteins
WO2005019251A3 (en) Novel fungal proteins and nucleic acids encoding same
WO2001092308A3 (en) Cystine-knot polypeptides: cloaked-2 molecules and uses thereof
WO2006067122A3 (en) Binding molecules capable of neutralizing west nile virus and uses thereof
WO2005123916A3 (en) Glycosylation-disrupted factor vii variants
WO2005005599A3 (en) Modulation of c-reactive protein expression
MX2009005935A (en) Chemical compounds and uses.
ATE512980T1 (en) POLYPEPTIDES WITH BETA-GLUCOSIDASE ACTIVITY AND POLYNUCLEOTIDES CODING THESE
WO2005063819A3 (en) Human binding molecule against cd1a
WO2004065380A8 (en) 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
WO2006124892A3 (en) Modulators of alpha-synuclein toxicity
WO2004053059A3 (en) Mitoneet polypeptide from mitochondrial membranes, modulators thereof, and methods of using the same
WO2003093316A3 (en) Immunoglobulin-domain containing cell surface recognition molecules
WO2004113500A3 (en) B7s1: an immune modulator
WO2004009024A3 (en) Modulation of protein kinase c-iota expression
WO2005077397A3 (en) Methods and compositions for treating vascular diseases
WO2006122971A3 (en) Treatment of disease using an improved regulated expression system
WO2006016172A3 (en) Cell surface glycoprotein
WO2004056982A3 (en) Kinase sequences
WO2005023979A3 (en) Isolated s. mansoni nucleic acid molecules and uses thereof
WO2004048524A3 (en) Modulation of stat2 expression
WO2005005471A3 (en) Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003813586

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003813586

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006275767

Country of ref document: US

Ref document number: 10540634

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 10540634

Country of ref document: US