WO2004052914A3 - Compositions and methods for inhibiting malaria protease falcipain-2 - Google Patents

Compositions and methods for inhibiting malaria protease falcipain-2 Download PDF

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Publication number
WO2004052914A3
WO2004052914A3 PCT/US2003/038835 US0338835W WO2004052914A3 WO 2004052914 A3 WO2004052914 A3 WO 2004052914A3 US 0338835 W US0338835 W US 0338835W WO 2004052914 A3 WO2004052914 A3 WO 2004052914A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
falcipain
peptides
compositions
antibodies
Prior art date
Application number
PCT/US2003/038835
Other languages
French (fr)
Other versions
WO2004052914A2 (en
WO2004052914A8 (en
Inventor
Manjit Hanspal
Athar H Chishti
Original Assignee
Caritas St Elizabeths Boston
Manjit Hanspal
Athar H Chishti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caritas St Elizabeths Boston, Manjit Hanspal, Athar H Chishti filed Critical Caritas St Elizabeths Boston
Priority to AU2003298035A priority Critical patent/AU2003298035A1/en
Publication of WO2004052914A2 publication Critical patent/WO2004052914A2/en
Publication of WO2004052914A8 publication Critical patent/WO2004052914A8/en
Publication of WO2004052914A3 publication Critical patent/WO2004052914A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention provides peptides derived from ankyrin and erythrocyte protein 4.1 that selectively inhibit falcipain-2-mediated cleavage of human erythrocyte protein 4.1, erythrocyte membrane ankyrin, and hemoglobin. Antibodies that bind to the falcipain-2 inhibitor peptides also are provided. Methods for selecting agents which inhibit falcipain-2 mediated parasite exit from host cells and methods of treatment which involve the peptides, nucleic acids encoding the peptides, and antibodies also are provided.
PCT/US2003/038835 2002-12-06 2003-12-05 Compositions and methods for inhibiting malaria protease falcipain-2 WO2004052914A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003298035A AU2003298035A1 (en) 2002-12-06 2003-12-05 Compositions and methods for inhibiting malaria protease falcipain-2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43129402P 2002-12-06 2002-12-06
US60/431,294 2002-12-06

Publications (3)

Publication Number Publication Date
WO2004052914A2 WO2004052914A2 (en) 2004-06-24
WO2004052914A8 WO2004052914A8 (en) 2004-10-14
WO2004052914A3 true WO2004052914A3 (en) 2004-12-29

Family

ID=32507704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038835 WO2004052914A2 (en) 2002-12-06 2003-12-05 Compositions and methods for inhibiting malaria protease falcipain-2

Country Status (2)

Country Link
AU (1) AU2003298035A1 (en)
WO (1) WO2004052914A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3142680A4 (en) * 2014-05-16 2018-05-23 Intermune, Inc. Lpa-associated protein and rna expression
CN110297095A (en) * 2019-07-26 2019-10-01 四川农业大学 A kind of screening technique of insect allergic protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225086B1 (en) * 1997-05-21 2001-05-01 Yale University Polynucleotides encoding ankyrin proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225086B1 (en) * 1997-05-21 2001-05-01 Yale University Polynucleotides encoding ankyrin proteins

Also Published As

Publication number Publication date
WO2004052914A2 (en) 2004-06-24
AU2003298035A8 (en) 2004-06-30
AU2003298035A1 (en) 2004-06-30
WO2004052914A8 (en) 2004-10-14

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