WO2004052905A3 - Antiviral nucleoside derivatives - Google Patents

Antiviral nucleoside derivatives Download PDF

Info

Publication number
WO2004052905A3
WO2004052905A3 PCT/EP2003/013538 EP0313538W WO2004052905A3 WO 2004052905 A3 WO2004052905 A3 WO 2004052905A3 EP 0313538 W EP0313538 W EP 0313538W WO 2004052905 A3 WO2004052905 A3 WO 2004052905A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleoside derivatives
compounds
antiviral nucleoside
hepatitis
treatment
Prior art date
Application number
PCT/EP2003/013538
Other languages
French (fr)
Other versions
WO2004052905A2 (en
Inventor
Robert Than Hendricks
Eric Roy Humphreys
Joseph Armstrong Martin
Anthony Prince
Keshab Sarma
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to AU2003296601A priority Critical patent/AU2003296601A1/en
Priority to CA002508656A priority patent/CA2508656A1/en
Priority to JP2004557964A priority patent/JP2006510645A/en
Priority to EP03812589A priority patent/EP1572710A2/en
Publication of WO2004052905A2 publication Critical patent/WO2004052905A2/en
Publication of WO2004052905A3 publication Critical patent/WO2004052905A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Abstract

The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula (I) and (II), pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy.
PCT/EP2003/013538 2002-12-10 2003-12-02 Antiviral nucleoside derivatives WO2004052905A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003296601A AU2003296601A1 (en) 2002-12-10 2003-12-02 Antiviral nucleoside derivatives
CA002508656A CA2508656A1 (en) 2002-12-10 2003-12-02 Antiviral nucleoside derivatives
JP2004557964A JP2006510645A (en) 2002-12-10 2003-12-02 Antiviral nucleoside derivatives
EP03812589A EP1572710A2 (en) 2002-12-10 2003-12-02 Antiviral nucleoside derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43210802P 2002-12-10 2002-12-10
US60/432,108 2002-12-10

Publications (2)

Publication Number Publication Date
WO2004052905A2 WO2004052905A2 (en) 2004-06-24
WO2004052905A3 true WO2004052905A3 (en) 2004-10-14

Family

ID=32507851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/013538 WO2004052905A2 (en) 2002-12-10 2003-12-02 Antiviral nucleoside derivatives

Country Status (12)

Country Link
US (1) US20040121969A1 (en)
EP (1) EP1572710A2 (en)
JP (1) JP2006510645A (en)
CN (1) CN1742018A (en)
AR (1) AR042335A1 (en)
AU (1) AU2003296601A1 (en)
CA (1) CA2508656A1 (en)
GT (1) GT200300275A (en)
PA (1) PA8590801A1 (en)
PE (1) PE20040903A1 (en)
TW (1) TW200417372A (en)
WO (1) WO2004052905A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0310593D0 (en) * 2003-05-08 2003-06-11 Leuven K U Res & Dev Peptidic prodrugs
WO2005023827A1 (en) * 2003-09-11 2005-03-17 F. Hoffmann-La Roche Ag Process for preparing antiviral nucleoside derivatives
JP2007505071A (en) 2003-09-11 2007-03-08 エフ．ホフマン−ラ　ロシュ　アーゲー Crystalline polymorphic nucleoside compounds
FR2869616B1 (en) * 2004-04-29 2008-10-24 Univ D Avignon Et Des Pays Du NOVEL AMPHIPHILIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATIONS IN PARTICULAR FOR TRANSFECTION
AU2005285045B2 (en) 2004-09-14 2011-10-13 Gilead Pharmasset Llc Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
WO2009105258A1 (en) 2008-02-22 2009-08-27 Nektar Therapeutics Al, Corporation Oligomer conjugates of heteropentacyclic nucleosides
EP2113508A1 (en) * 2008-04-30 2009-11-04 INSERM (Institut National de la Santé et de la Recherche Medicale) Novel triazole nucleoside derivatives, their preparation and their application in therapeutics
JP6824062B2 (en) * 2017-02-14 2021-02-03 日本電子株式会社 Ionization method selection support device and method
WO2018230479A1 (en) * 2017-06-13 2018-12-20 大原薬品工業株式会社 5'-position silyl ether derivative for nucleoside anti-cancer agent or anti-virus agent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046212A1 (en) * 1999-12-23 2001-06-28 Icn Pharmaceuticals, Inc. Treatment of viral infections using levovirin?tm¿
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
WO2001068034A2 (en) * 2000-03-15 2001-09-20 Ribapharm Corp. 1, 2, 4-triazoloribonucleoside prodrugs and their administration to treat viral disease conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998807A (en) * 1972-03-03 1976-12-21 Syntex (U.S.A.) Inc. Arabinofuranosyl cytosines and methods of making
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
US6184376B1 (en) * 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
WO2001046212A1 (en) * 1999-12-23 2001-06-28 Icn Pharmaceuticals, Inc. Treatment of viral infections using levovirin?tm¿
WO2001068034A2 (en) * 2000-03-15 2001-09-20 Ribapharm Corp. 1, 2, 4-triazoloribonucleoside prodrugs and their administration to treat viral disease conditions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAMASAMY K S ET AL: "Monocyclic L-Nucleosides with Type 1 Cytokine-Inducing Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, 2000, pages 1019 - 1028, XP002258899, ISSN: 0022-2623 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides

Also Published As

Publication number Publication date
TW200417372A (en) 2004-09-16
AR042335A1 (en) 2005-06-15
AU2003296601A8 (en) 2004-06-30
PA8590801A1 (en) 2004-11-26
JP2006510645A (en) 2006-03-30
PE20040903A1 (en) 2004-12-02
US20040121969A1 (en) 2004-06-24
AU2003296601A1 (en) 2004-06-30
EP1572710A2 (en) 2005-09-14
GT200300275A (en) 2004-06-28
WO2004052905A2 (en) 2004-06-24
CN1742018A (en) 2006-03-01
CA2508656A1 (en) 2004-06-24

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