WO2004050686A3 - Process and supports for synthesis of peptides comprising a thioester or thioacid - Google Patents

Process and supports for synthesis of peptides comprising a thioester or thioacid Download PDF

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Publication number
WO2004050686A3
WO2004050686A3 PCT/GB2003/004967 GB0304967W WO2004050686A3 WO 2004050686 A3 WO2004050686 A3 WO 2004050686A3 GB 0304967 W GB0304967 W GB 0304967W WO 2004050686 A3 WO2004050686 A3 WO 2004050686A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
supports
thioacid
thioester
peptides
Prior art date
Application number
PCT/GB2003/004967
Other languages
French (fr)
Other versions
WO2004050686A2 (en
Inventor
David John Evans
Original Assignee
Avecia Ltd
David John Evans
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd, David John Evans filed Critical Avecia Ltd
Priority to AU2003283579A priority Critical patent/AU2003283579A1/en
Publication of WO2004050686A2 publication Critical patent/WO2004050686A2/en
Publication of WO2004050686A3 publication Critical patent/WO2004050686A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A process for the Fmoc synthesis of a peptide comprising a thioester or thioacid which comprises removing the Nα-Fmoc blocking group with a base selected from optionally substituted piperazine or optionally substituted 2,6-C1-4dialkyl-piperidine or a mixture thereof. Also novel solid supports suitable for the solid-state synthesis of peptide thioesters and thioacids and processes for making these supports.
PCT/GB2003/004967 2002-11-29 2003-11-17 Process and supports for synthesis of peptides comprising a thioester or thioacid WO2004050686A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003283579A AU2003283579A1 (en) 2002-11-29 2003-11-17 Process and supports for synthesis of peptides comprising a thioester or thioacid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0227876.0 2002-11-29
GB0227876A GB0227876D0 (en) 2002-11-29 2002-11-29 Process and supports

Publications (2)

Publication Number Publication Date
WO2004050686A2 WO2004050686A2 (en) 2004-06-17
WO2004050686A3 true WO2004050686A3 (en) 2004-11-11

Family

ID=9948769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004967 WO2004050686A2 (en) 2002-11-29 2003-11-17 Process and supports for synthesis of peptides comprising a thioester or thioacid

Country Status (3)

Country Link
AU (1) AU2003283579A1 (en)
GB (1) GB0227876D0 (en)
WO (1) WO2004050686A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018417A1 (en) * 2000-09-01 2002-03-07 Gryphon Therapeutics, Inc. Nucleophile-stable thioester generating compounds, methods of production and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018417A1 (en) * 2000-09-01 2002-03-07 Gryphon Therapeutics, Inc. Nucleophile-stable thioester generating compounds, methods of production and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLIPPINGDALE A B ET AL: "PEPTIDE THIOESTER PREPARATION BY FMOC SOLID PHASE PEPTIDE SYNTHESIS FOR USE IN NATIVE CHEMICAL LIGATION", JOURNAL OF PEPTIDE SCIENCE, JOHN WILEY AND SONS LTD, GB, vol. 6, no. 5, May 2000 (2000-05-01), pages 225 - 234, XP009015362, ISSN: 1075-2617 *
HASEGAWA KOKI ET AL: "Preparation of phosphopeptide thioesters by Fmoc- and Fmoc(2-F)-solid phase synthesis", LETTERS IN PEPTIDE SCIENCE, vol. 8, no. 3-5, 2001, pages 277 - 284, XP002271259, ISSN: 0929-5666 *
LI X ET AL: "Direct preparation of peptide thioesters using an Fmoc solid-phase method", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 47, 19 November 1998 (1998-11-19), pages 8669 - 8672, XP004140611, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
GB0227876D0 (en) 2003-01-08
WO2004050686A2 (en) 2004-06-17
AU2003283579A8 (en) 2004-06-23
AU2003283579A1 (en) 2004-06-23

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