WO2004050180A3 - Method and apparatus for cell and electrical therapy of living tissue - Google Patents

Method and apparatus for cell and electrical therapy of living tissue Download PDF

Info

Publication number
WO2004050180A3
WO2004050180A3 PCT/US2003/038085 US0338085W WO2004050180A3 WO 2004050180 A3 WO2004050180 A3 WO 2004050180A3 US 0338085 W US0338085 W US 0338085W WO 2004050180 A3 WO2004050180 A3 WO 2004050180A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
application
electrical therapy
tissue
therapy
Prior art date
Application number
PCT/US2003/038085
Other languages
French (fr)
Other versions
WO2004050180A2 (en
Inventor
Steven D Girouard
Rodney W Salo
Bruce H Kenknight
Original Assignee
Cardiac Pacemakers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/723,258 external-priority patent/US7627373B2/en
Priority claimed from US10/722,115 external-priority patent/US20040158289A1/en
Application filed by Cardiac Pacemakers Inc filed Critical Cardiac Pacemakers Inc
Priority to AU2003297592A priority Critical patent/AU2003297592A1/en
Priority to EP03812469A priority patent/EP1569717A2/en
Priority to JP2004570974A priority patent/JP2006511312A/en
Publication of WO2004050180A2 publication Critical patent/WO2004050180A2/en
Publication of WO2004050180A3 publication Critical patent/WO2004050180A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the exogenous cells are conditioned in vitro before their administration into tissue. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD or DDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
PCT/US2003/038085 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue WO2004050180A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003297592A AU2003297592A1 (en) 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue
EP03812469A EP1569717A2 (en) 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue
JP2004570974A JP2006511312A (en) 2002-11-30 2003-11-26 Method and apparatus for cell therapy and electrotherapy of biological tissue

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US42995402P 2002-11-30 2002-11-30
US60/429,954 2002-11-30
US48302803P 2003-06-27 2003-06-27
US60/483,028 2003-06-27
US10/722,115 2003-11-25
US10/723,258 US7627373B2 (en) 2002-11-30 2003-11-25 Method and apparatus for cell and electrical therapy of living tissue
US10/722,115 US20040158289A1 (en) 2002-11-30 2003-11-25 Method and apparatus for cell and electrical therapy of living tissue
US10/723,258 2003-11-25

Publications (2)

Publication Number Publication Date
WO2004050180A2 WO2004050180A2 (en) 2004-06-17
WO2004050180A3 true WO2004050180A3 (en) 2004-11-11

Family

ID=33425557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038085 WO2004050180A2 (en) 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue

Country Status (4)

Country Link
EP (1) EP1569717A2 (en)
JP (2) JP2006511312A (en)
AU (1) AU2003297592A1 (en)
WO (1) WO2004050180A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US20070003528A1 (en) 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
JP2009502259A (en) * 2005-07-21 2009-01-29 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Tandem cardiac pacemaker system
US20070190028A1 (en) * 2006-02-13 2007-08-16 Jihong Qu Method and apparatus for heat or electromagnetic control of gene expression
US7787950B1 (en) 2006-11-03 2010-08-31 Pacesetter, Inc. Techniques for delivery of stem cell and related therapies to treat cardiac conditions
US8019416B2 (en) * 2006-11-13 2011-09-13 Cardiac Pacemakers, Inc. Reduction of AV delay for treatment of cardiac disease
WO2009151516A2 (en) * 2008-05-08 2009-12-17 Cardiac Pacemakers, Inc. Smart delay for intermittent stress therapy
US8761883B2 (en) 2011-08-31 2014-06-24 St. Jude Medical Ab Physiologically adapted cardiac resynchronization therapy
CN104936603A (en) 2012-08-01 2015-09-23 联合治疗公司 Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
CN111803523A (en) 2012-08-01 2020-10-23 联合治疗公司 Treatment of pulmonary hypertension using mesenchymal stem cells
ES2697573T3 (en) * 2013-01-09 2019-01-25 United Therapeutics Corp Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US10940318B2 (en) * 2014-06-17 2021-03-09 Morton M. Mower Method and apparatus for electrical current therapy of biological tissue
KR102606101B1 (en) 2016-10-24 2023-11-27 유나이티드 쎄러퓨틱스 코포레이션 Enhancement of MSC immunomodulatory properties by treprostinil
CN114849060B (en) * 2022-05-07 2023-08-25 江苏省人民医院（南京医科大学第一附属医院） Application of electric stimulation in regulation and control of MDK in organism

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336252A (en) * 1992-06-22 1994-08-09 Cohen Donald M System and method for implanting cardiac electrical leads
WO1998002150A1 (en) * 1996-07-17 1998-01-22 Medtronic, Inc. System for genetically treating cardiac conduction disturbances
WO1998015317A1 (en) * 1996-10-07 1998-04-16 Sulzer Intermedics Inc. Controllable drug injection electrode
WO2000027466A1 (en) * 1998-11-12 2000-05-18 Emed Corporation Electrically mediated angiogenesis
WO2000054661A1 (en) * 1999-03-17 2000-09-21 Angiotrax, Inc. Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials
EP1142607A2 (en) * 2000-04-03 2001-10-10 Medtronic, Inc. Dual chamber pacing system having time-adaptive AV delay
US20020032468A1 (en) * 1996-04-30 2002-03-14 Hill Michael R.S. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
WO2002049669A2 (en) * 2000-12-21 2002-06-27 Medtronic, Inc. Electrically responsive promoter system
US20020124855A1 (en) * 2001-03-12 2002-09-12 Chachques Juan C. Method of providing a dynamic cellular cardiac support
WO2002070065A2 (en) * 2001-03-05 2002-09-12 Medtronic, Inc. Stimulation for delivery of molecular therapy
US20020133198A1 (en) * 2001-03-16 2002-09-19 Kramer Andrew P. Automatic selection from multiple cardiac optimization protocols

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5282838A (en) * 1992-06-08 1994-02-01 Cardiac Pacemakers, Inc. Dual chamber cardiac pacemaker employing hysteresis to maximize the number of normally conducted ventricular beats with an optimum A-V delay for paced ventricular beats
US5831008A (en) 1994-08-18 1998-11-03 La Jolla Cancer Research Foundation Retinoblastoma protein-interacting zinc finger proteins

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336252A (en) * 1992-06-22 1994-08-09 Cohen Donald M System and method for implanting cardiac electrical leads
US20020032468A1 (en) * 1996-04-30 2002-03-14 Hill Michael R.S. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
WO1998002150A1 (en) * 1996-07-17 1998-01-22 Medtronic, Inc. System for genetically treating cardiac conduction disturbances
WO1998015317A1 (en) * 1996-10-07 1998-04-16 Sulzer Intermedics Inc. Controllable drug injection electrode
WO2000027466A1 (en) * 1998-11-12 2000-05-18 Emed Corporation Electrically mediated angiogenesis
WO2000054661A1 (en) * 1999-03-17 2000-09-21 Angiotrax, Inc. Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials
EP1142607A2 (en) * 2000-04-03 2001-10-10 Medtronic, Inc. Dual chamber pacing system having time-adaptive AV delay
WO2002049669A2 (en) * 2000-12-21 2002-06-27 Medtronic, Inc. Electrically responsive promoter system
WO2002070065A2 (en) * 2001-03-05 2002-09-12 Medtronic, Inc. Stimulation for delivery of molecular therapy
US20020124855A1 (en) * 2001-03-12 2002-09-12 Chachques Juan C. Method of providing a dynamic cellular cardiac support
US20020133198A1 (en) * 2001-03-16 2002-09-19 Kramer Andrew P. Automatic selection from multiple cardiac optimization protocols

Also Published As

Publication number Publication date
EP1569717A2 (en) 2005-09-07
WO2004050180A2 (en) 2004-06-17
JP2006511312A (en) 2006-04-06
AU2003297592A1 (en) 2004-06-23
JP2009178593A (en) 2009-08-13

Similar Documents

Publication Publication Date Title
WO2004050180A3 (en) Method and apparatus for cell and electrical therapy of living tissue
Long et al. Wearable and implantable electroceuticals for therapeutic electrostimulations
EP1863564B1 (en) Combined neural stimulation and cardiac resynchronization therapy
US7840266B2 (en) Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy
US11083904B2 (en) Bisphasic or multiphasic pulse waveform and method
WO2005051480A3 (en) Electrical stimulation system, lead, and method providing reduced neuroplasticity effects
WO2007149588A3 (en) Transesophageal implantation of cardiac electrodes
WO2008039619A3 (en) Temporary leadless pacing systems and methods
WO2006069215A3 (en) Leadless cardiac system for pacing and arrhythmia treatment
US20070066879A1 (en) Body lumen shaping device with cardiac leads
AU2003223583A1 (en) Devices and methods for transluminal or transthoracic interstitial electrode placement
WO2000032749A3 (en) Methods and articles for regenerating living tissue
WO2005000398A3 (en) Intravascular electrophysiological system and methods
JP2005537909A5 (en)
WO2005035055A3 (en) Multiple pacing output channels
JP2008523892A5 (en)
CA2249993A1 (en) Left ventricular access lead for heart failure pacing
WO2000004950A3 (en) Method and apparatus for dual chamber bi-ventricular pacing and defibrillation
WO2009018008A3 (en) Tools and method for implanting a subcutaneous device
WO2010134007A3 (en) Low-level energy laser therapy
WO2007015907A3 (en) Stimulation electrode array
Holmes The role of lithium batteries in modern health care
WO2003061455A3 (en) An apical patch and method of use
WO2004010953A3 (en) Implantable artificial organ devices
Mond et al. The Australian history of cardiac pacing: memories from a bygone era

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004570974

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003812469

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003812469

Country of ref document: EP