WO2004050124A3 - Chimaeric molecules - Google Patents

Chimaeric molecules Download PDF

Info

Publication number
WO2004050124A3
WO2004050124A3 PCT/GB2003/005241 GB0305241W WO2004050124A3 WO 2004050124 A3 WO2004050124 A3 WO 2004050124A3 GB 0305241 W GB0305241 W GB 0305241W WO 2004050124 A3 WO2004050124 A3 WO 2004050124A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agent
chemokine receptor
molecule
chimaeric
tissue
Prior art date
Application number
PCT/GB2003/005241
Other languages
French (fr)
Other versions
WO2004050124A2 (en
Inventor
Sian Mari Henson
Richard Aspinall
Original Assignee
Imp College Innovations Ltd
Sian Mari Henson
Richard Aspinall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imp College Innovations Ltd, Sian Mari Henson, Richard Aspinall filed Critical Imp College Innovations Ltd
Priority to AU2003285574A priority Critical patent/AU2003285574A1/en
Publication of WO2004050124A2 publication Critical patent/WO2004050124A2/en
Publication of WO2004050124A3 publication Critical patent/WO2004050124A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

Abstract

A chimaeric molecule comprising a therapeutic agent and a chemokine receptor molecule or portion thereof. The therapeutic agent may be a cytokine or chemokine. The therapeutic agent may act on a cell, tissue or organ in which the ligand for the chemokine receptor molecule may naturally be found. The therapeutic agent may be IL-7 and the chemokine receptor CCR9 A chimaeric molecule comprising IL-7 and a targeting moiety for targeting the IL-7 to a tissue in which T cell proliferation and/or development can occur. The targeting moiety may be the chemokine receptor CCR9 or a portion thereof.
PCT/GB2003/005241 2002-12-02 2003-12-01 Chimaeric molecules WO2004050124A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003285574A AU2003285574A1 (en) 2002-12-02 2003-12-01 Chimaeric molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0227989.1 2002-12-02
GB0227989A GB0227989D0 (en) 2002-12-02 2002-12-02 Chimaeric molecules

Publications (2)

Publication Number Publication Date
WO2004050124A2 WO2004050124A2 (en) 2004-06-17
WO2004050124A3 true WO2004050124A3 (en) 2004-07-15

Family

ID=9948857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/005241 WO2004050124A2 (en) 2002-12-02 2003-12-01 Chimaeric molecules

Country Status (3)

Country Link
AU (1) AU2003285574A1 (en)
GB (1) GB0227989D0 (en)
WO (1) WO2004050124A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965122A (en) * 1987-10-26 1999-10-12 Sanofi Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors
US6039941A (en) * 1994-08-24 2000-03-21 Max-Delbruck-Centrum Fur Molekulare Medizin Live vaccine for the treatment of tumor diseases
US20020058791A1 (en) * 2000-03-30 2002-05-16 Irving Goldschneider Hybrid cytokine of IL-7 and beta-chain of hepatocyte growth factor
WO2003095967A2 (en) * 2002-05-14 2003-11-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965122A (en) * 1987-10-26 1999-10-12 Sanofi Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors
US6039941A (en) * 1994-08-24 2000-03-21 Max-Delbruck-Centrum Fur Molekulare Medizin Live vaccine for the treatment of tumor diseases
US20020058791A1 (en) * 2000-03-30 2002-05-16 Irving Goldschneider Hybrid cytokine of IL-7 and beta-chain of hepatocyte growth factor
WO2003095967A2 (en) * 2002-05-14 2003-11-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOWMAN EDWARD P ET AL: "Developmental switches in chemokine response profiles during B cell differentiation and maturation", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 191, no. 8, 17 April 2000 (2000-04-17), pages 1303 - 1317, XP002280546, ISSN: 0022-1007 *
PAPADAKIS K A ET AL: "The role of thymus-expressed chemokine and its receptore CCR9 on lymphocytes in the regional specialization of the mucosal immune system 1", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 165, 2000, pages 5069 - 5076, XP002956582, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
AU2003285574A8 (en) 2004-06-23
AU2003285574A1 (en) 2004-06-23
WO2004050124A2 (en) 2004-06-17
GB0227989D0 (en) 2003-01-08

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