WO2004044586A8 - Nanotube-based electronic detection of biological molecules - Google Patents

Nanotube-based electronic detection of biological molecules

Info

Publication number
WO2004044586A8
WO2004044586A8 PCT/US2003/035635 US0335635W WO2004044586A8 WO 2004044586 A8 WO2004044586 A8 WO 2004044586A8 US 0335635 W US0335635 W US 0335635W WO 2004044586 A8 WO2004044586 A8 WO 2004044586A8
Authority
WO
WIPO (PCT)
Prior art keywords
nanotube
polymer
receptor
biological molecules
receptor compound
Prior art date
Application number
PCT/US2003/035635
Other languages
French (fr)
Other versions
WO2004044586A1 (en
Inventor
George Gruner
Alexander Star
Original Assignee
Nanomix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/345,783 external-priority patent/US20030134433A1/en
Priority claimed from US10/656,898 external-priority patent/US20050279987A1/en
Application filed by Nanomix Inc filed Critical Nanomix Inc
Priority to EP03768779A priority Critical patent/EP1558933A1/en
Priority to AU2003291385A priority patent/AU2003291385A1/en
Priority to JP2005507121A priority patent/JP2006505806A/en
Publication of WO2004044586A1 publication Critical patent/WO2004044586A1/en
Publication of WO2004044586A8 publication Critical patent/WO2004044586A8/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Thin Film Transistor (AREA)

Abstract

Nanoscale field effect transistor devices with carbon nanotubes as the conducting channel are used to detect protein-protein binding. A coating of an electron-donating polymer is applied to a nanotube device, and a receptor compound is bound to the polymer. The receptor compound is configured to bind a specific biological molecule or molecules. The device coated with the polymer coating and receptor compound may be operated as a p-type field-effect transducer. For example, upon exposure to biological molecules bound by the receptor, the conductance at negative voltage may be markedly reduced, thereby establishing an electronic signal response.
PCT/US2003/035635 2002-11-08 2003-11-07 Nanotube-based electronic detection of biological molecules WO2004044586A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03768779A EP1558933A1 (en) 2002-11-08 2003-11-07 Nanotube-based electronic detection of biological molecules
AU2003291385A AU2003291385A1 (en) 2002-11-08 2003-11-07 Nanotube-based electronic detection of biological molecules
JP2005507121A JP2006505806A (en) 2002-11-08 2003-11-07 Electronic detection of nanotube-based biomolecules

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US42489202P 2002-11-08 2002-11-08
US60/424,892 2002-11-08
US10/345,783 US20030134433A1 (en) 2002-01-16 2003-01-16 Electronic sensing of chemical and biological agents using functionalized nanostructures
US10/345,783 2003-01-16
US10/656,898 2003-09-05
US10/656,898 US20050279987A1 (en) 2002-09-05 2003-09-05 Nanostructure sensor device with polymer recognition layer

Publications (2)

Publication Number Publication Date
WO2004044586A1 WO2004044586A1 (en) 2004-05-27
WO2004044586A8 true WO2004044586A8 (en) 2005-07-07

Family

ID=36337451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/035635 WO2004044586A1 (en) 2002-11-08 2003-11-07 Nanotube-based electronic detection of biological molecules

Country Status (4)

Country Link
EP (1) EP1558933A1 (en)
JP (1) JP2006505806A (en)
AU (1) AU2003291385A1 (en)
WO (1) WO2004044586A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547931B2 (en) 2003-09-05 2009-06-16 Nanomix, Inc. Nanoelectronic capnometer adaptor including a nanoelectric sensor selectively sensitive to at least one gaseous constituent of exhaled breath
US7714398B2 (en) * 2002-09-05 2010-05-11 Nanomix, Inc. Nanoelectronic measurement system for physiologic gases and improved nanosensor for carbon dioxide
US7522040B2 (en) 2004-04-20 2009-04-21 Nanomix, Inc. Remotely communicating, battery-powered nanostructure sensor devices
US20050129573A1 (en) * 2003-09-12 2005-06-16 Nanomix, Inc. Carbon dioxide nanoelectronic sensor
US7955483B2 (en) * 2002-03-18 2011-06-07 Honeywell International Inc. Carbon nanotube-based glucose sensor
WO2005043160A2 (en) * 2003-10-31 2005-05-12 University Of Hawaii Ultrasensitive biochemical sensing platform
US7247877B2 (en) * 2004-08-20 2007-07-24 International Business Machines Corporation Integrated carbon nanotube sensors
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
WO2006052891A1 (en) * 2004-11-09 2006-05-18 The Regents Of The University Of California Analyte identification using electronic devices
EP1831670A4 (en) * 2004-12-28 2010-09-15 Nanomix Inc Nanoelectronic devices for dna detection, and recognition of polynucleotide sequences
DE102005011012A1 (en) * 2005-03-10 2006-09-14 Steinbeis GmbH & Co. für Technologietransfer Zell-Chip-Technologien Chemical sensor for detecting oxidizable/reducible substance e.g. gaseous oxygen, has carbon-nano tubes with surface connected to evaluation unit, and reference electrode with surface made of electrically conducting material containing gold
US7776269B2 (en) * 2005-03-15 2010-08-17 The United States Of America As Represented By The Secretary Of The Navy Capacitive based sensing of molecular adsorbates on the surface of single wall nanotubes
JP4742650B2 (en) * 2005-04-08 2011-08-10 東レ株式会社 Carbon nanotube composition, biosensor, and production method thereof
KR100748408B1 (en) * 2005-06-28 2007-08-10 한국화학연구원 Carbon nanotube biosensors with aptamers as molecular recognition elements and method for sensing target material using the same
WO2007109228A1 (en) * 2006-03-17 2007-09-27 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Apparatus for microarray binding sensors having biological probe materials using carbon nanotube transistors
KR100842886B1 (en) * 2006-04-04 2008-07-02 재단법인서울대학교산학협력재단 Biosensor having nano wire for detecting food additive mono sodium glutamate and manufacturing method thereof
KR100758285B1 (en) * 2006-09-27 2007-09-12 한국전자통신연구원 A bio sensor, method for manufacturing the same and a bio sensing apparatus with the same
JP2008116356A (en) * 2006-11-06 2008-05-22 Nec Corp Observation device and observation method
CA2701380C (en) * 2007-10-01 2014-03-11 University Of Southern California Detection of methylated dna and dna mutations
FI122511B (en) * 2009-02-26 2012-02-29 Valtion Teknillinen Graphene-containing flakes and procedure for exfoliating the graphene
JP2012529056A (en) * 2009-06-05 2012-11-15 アリゾナ・ボード・オブ・リージェンツ・アクティング・フォー・アンド・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティ Integrated photoelectrochemical sensor for nitric oxide in gaseous samples
KR101040083B1 (en) 2009-07-27 2011-06-09 전자부품연구원 nanowire transistor sensor, manufacturing method and nanoparticle detection apparatus using the same
JP6076738B2 (en) * 2009-09-11 2017-02-08 ジェイピー ラボラトリーズ インコーポレイテッド Monitoring device and method based on deformation, destruction and transformation of nanostructures
KR101263188B1 (en) * 2011-04-14 2013-05-10 포항공과대학교 산학협력단 Nanowire Sensor having a Network Nanowire and the manufacturing method
KR102068087B1 (en) * 2017-03-24 2020-01-20 가천대학교 산학협력단 Insulin detection sensor based on nanowire field-effect transistor
JP6857353B2 (en) * 2017-03-30 2021-04-14 国立大学法人東北大学 Biomolecular sensor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100469868B1 (en) * 1996-03-06 2005-07-08 하이페리온 커탤리시스 인터내셔널 인코포레이티드 Functionalized Nanotubes
WO2001044796A1 (en) * 1999-12-15 2001-06-21 Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube devices
KR100991573B1 (en) * 2000-12-11 2010-11-04 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 Nanosensors
WO2002079514A1 (en) * 2001-01-10 2002-10-10 The Trustees Of Boston College Dna-bridged carbon nanotube arrays
US8029734B2 (en) * 2001-03-29 2011-10-04 The Board Of Trustees Of The Leland Stanford Junior University Noncovalent sidewall functionalization of carbon nanotubes
KR100455284B1 (en) * 2001-08-14 2004-11-12 삼성전자주식회사 High-throughput sensor for detecting biomolecules using carbon nanotubes
US20030134433A1 (en) * 2002-01-16 2003-07-17 Nanomix, Inc. Electronic sensing of chemical and biological agents using functionalized nanostructures

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection

Also Published As

Publication number Publication date
JP2006505806A (en) 2006-02-16
WO2004044586A1 (en) 2004-05-27
AU2003291385A1 (en) 2004-06-03
EP1558933A1 (en) 2005-08-03

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