WO2004044246A3 - Methods and compositions for detecting telomerase activity - Google Patents
Methods and compositions for detecting telomerase activity Download PDFInfo
- Publication number
- WO2004044246A3 WO2004044246A3 PCT/US2003/035919 US0335919W WO2004044246A3 WO 2004044246 A3 WO2004044246 A3 WO 2004044246A3 US 0335919 W US0335919 W US 0335919W WO 2004044246 A3 WO2004044246 A3 WO 2004044246A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reaction mixture
- primer
- extension product
- telomerase activity
- biological sample
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/113—Telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/113—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an external standard/control, i.e. control reaction is separated from the test/target reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2547/00—Reactions characterised by the features used to prevent contamination
- C12Q2547/10—Reactions characterised by the features used to prevent contamination the purpose being preventing contamination
- C12Q2547/101—Reactions characterised by the features used to prevent contamination the purpose being preventing contamination by confinement to a single tube/container
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2547/00—Reactions characterised by the features used to prevent contamination
- C12Q2547/10—Reactions characterised by the features used to prevent contamination the purpose being preventing contamination
- C12Q2547/107—Use of permeable barriers, e.g. waxes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2561/00—Nucleic acid detection characterised by assay method
- C12Q2561/113—Real time assay
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03783305A EP1563096A2 (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
CA002505871A CA2505871A1 (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
MXPA05005039A MXPA05005039A (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity. |
CN200380107388.5A CN1732271B (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
JP2004552056A JP2006506068A (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
US10/534,978 US7390621B2 (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
AU2003290722A AU2003290722A1 (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42562002P | 2002-11-12 | 2002-11-12 | |
US60/425,620 | 2002-11-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004044246A2 WO2004044246A2 (en) | 2004-05-27 |
WO2004044246A3 true WO2004044246A3 (en) | 2004-10-21 |
Family
ID=32313028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/035919 WO2004044246A2 (en) | 2002-11-12 | 2003-11-12 | Methods and compositions for detecting telomerase activity |
Country Status (10)
Country | Link |
---|---|
US (1) | US7390621B2 (en) |
EP (1) | EP1563096A2 (en) |
JP (1) | JP2006506068A (en) |
KR (1) | KR20050086563A (en) |
CN (1) | CN1732271B (en) |
AU (1) | AU2003290722A1 (en) |
CA (1) | CA2505871A1 (en) |
MX (1) | MXPA05005039A (en) |
RU (1) | RU2005118073A (en) |
WO (1) | WO2004044246A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101601378B (en) * | 2009-07-20 | 2012-09-05 | 同昕生物技术(北京)有限公司 | High-efficiency rapid bladder cancer urinalysis kit and urinary cell active preservative fluid |
CN101824486A (en) * | 2009-12-30 | 2010-09-08 | 华东医学生物技术研究所 | Method and device for rapidly detecting nucleic acid |
DK201000356A (en) * | 2010-04-22 | 2011-10-23 | Statens Seruminstitut | New nucleotide sequence amplification Method |
CN102220418A (en) * | 2011-04-22 | 2011-10-19 | 天津医科大学 | Dual temperature rapid cycling fluorescence quota PCR method for detecting telomerase activity and kit |
CN102887950B (en) * | 2012-10-10 | 2015-04-22 | 中国科学院动物研究所 | hnRNP A2* protein, nucleic acid for coding protein and application thereof |
CN103529023B (en) * | 2013-10-11 | 2015-07-29 | 东南大学 | A kind of activity test method of telomerase |
CN105648051A (en) * | 2015-11-25 | 2016-06-08 | 厦门多维生物医药科技有限公司 | Method for quantifying activity of cell telomerase |
JP6681545B2 (en) | 2016-03-28 | 2020-04-15 | パナソニックIpマネジメント株式会社 | Method for detecting cancer cells in aqueous solution |
CN107034280B (en) * | 2017-05-10 | 2019-12-27 | 菲鹏生物股份有限公司 | Method for detecting DNA polymerase activity and detection kit |
CN107340277B (en) * | 2017-06-06 | 2020-02-18 | 华东师范大学 | DNA silver nanocluster and cell in-situ synthesis method and application thereof |
CN111705114B (en) * | 2020-06-11 | 2023-08-15 | 湖南圣洲生物科技有限公司 | Method and kit for detecting absolute length of human telomeres based on real-time digital PCR |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629154A (en) * | 1993-11-12 | 1997-05-13 | Geron Corporation | Telomerase activity assays |
US5891639A (en) * | 1993-11-12 | 1999-04-06 | Geron Corporation | Telomerase activity assays |
US6221584B1 (en) * | 1995-11-28 | 2001-04-24 | Roche Diagnostics Gmbh | Method of detecting telomerase activity |
US6391554B1 (en) * | 1992-05-13 | 2002-05-21 | Geron Corporation And Board Of Regents | Detecting cancerous conditions by assaying for telomerase activity |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6492117B1 (en) * | 2000-07-12 | 2002-12-10 | Gendaq Limited | Zinc finger polypeptides capable of binding DNA quadruplexes |
-
2003
- 2003-11-12 JP JP2004552056A patent/JP2006506068A/en not_active Withdrawn
- 2003-11-12 CA CA002505871A patent/CA2505871A1/en not_active Abandoned
- 2003-11-12 KR KR1020057008478A patent/KR20050086563A/en not_active Application Discontinuation
- 2003-11-12 CN CN200380107388.5A patent/CN1732271B/en not_active Expired - Fee Related
- 2003-11-12 RU RU2005118073/13A patent/RU2005118073A/en not_active Application Discontinuation
- 2003-11-12 WO PCT/US2003/035919 patent/WO2004044246A2/en active Application Filing
- 2003-11-12 MX MXPA05005039A patent/MXPA05005039A/en not_active Application Discontinuation
- 2003-11-12 US US10/534,978 patent/US7390621B2/en not_active Expired - Fee Related
- 2003-11-12 AU AU2003290722A patent/AU2003290722A1/en not_active Abandoned
- 2003-11-12 EP EP03783305A patent/EP1563096A2/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391554B1 (en) * | 1992-05-13 | 2002-05-21 | Geron Corporation And Board Of Regents | Detecting cancerous conditions by assaying for telomerase activity |
US5629154A (en) * | 1993-11-12 | 1997-05-13 | Geron Corporation | Telomerase activity assays |
US5891639A (en) * | 1993-11-12 | 1999-04-06 | Geron Corporation | Telomerase activity assays |
US6221584B1 (en) * | 1995-11-28 | 2001-04-24 | Roche Diagnostics Gmbh | Method of detecting telomerase activity |
Non-Patent Citations (5)
Title |
---|
BURGER A M ET AL: "Inhibition of Telomerase Activity by Cisplatin in Human Testicular Cancer Cells", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 33, no. 4, April 1997 (1997-04-01), pages 638 - 644, XP004282569, ISSN: 0959-8049 * |
ELMORE ET AL: "Real-time quantitative analysis of telomerase activity in breast tumor specimens using a highly specific and sensitive fluorescent-based assay", DIAGNOSTIC MOLECULAR PATHOLOGY, vol. 11, no. 3, September 2002 (2002-09-01), pages 177 - 85, XP008029655 * |
HOU M ET AL: "Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity", CLINICAL CHEMISTRY, vol. 47, no. 3, 2001, pages 519 - 24, XP002276809 * |
SEIMIYA H ET AL: "Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295 and MST-199", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION OF CANCER RESEARCH, US, vol. 1, no. 9, 1 July 2002 (2002-07-01), pages 657 - 665, XP002971865, ISSN: 1535-7163 * |
UEHARA H ET AL: "Detection of telomerase activity utilizing energy transfer primers: comparison with gel- and ELISA-based detection", BIOTECHNIQUES, vol. 26, no. 3, 1999, pages 552 - 58, XP002276810 * |
Also Published As
Publication number | Publication date |
---|---|
KR20050086563A (en) | 2005-08-30 |
RU2005118073A (en) | 2006-06-10 |
US20060246441A1 (en) | 2006-11-02 |
AU2003290722A8 (en) | 2004-06-03 |
CN1732271B (en) | 2010-05-05 |
US7390621B2 (en) | 2008-06-24 |
CN1732271A (en) | 2006-02-08 |
JP2006506068A (en) | 2006-02-23 |
CA2505871A1 (en) | 2004-05-27 |
MXPA05005039A (en) | 2005-11-17 |
EP1563096A2 (en) | 2005-08-17 |
AU2003290722A1 (en) | 2004-06-03 |
WO2004044246A2 (en) | 2004-05-27 |
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