WO2004044196A1 - Procedes de diagnostic de maladies associees a la phosphodiesterase 7b (pde7b) humaine et moyens therapeutiques correspondants - Google Patents

Procedes de diagnostic de maladies associees a la phosphodiesterase 7b (pde7b) humaine et moyens therapeutiques correspondants Download PDF

Info

Publication number
WO2004044196A1
WO2004044196A1 PCT/EP2003/012342 EP0312342W WO2004044196A1 WO 2004044196 A1 WO2004044196 A1 WO 2004044196A1 EP 0312342 W EP0312342 W EP 0312342W WO 2004044196 A1 WO2004044196 A1 WO 2004044196A1
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
pde7b
disorders
polypeptide
cancer
Prior art date
Application number
PCT/EP2003/012342
Other languages
English (en)
Inventor
Stefan Golz
Ulf Brüggemeier
Holger Summer
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Priority to EP03772308A priority Critical patent/EP1608742A1/fr
Priority to AU2003279361A priority patent/AU2003279361A1/en
Publication of WO2004044196A1 publication Critical patent/WO2004044196A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention concerne une phosphodiestérase 7b (PDE7b) humaine qui est associée à des maladies cardiovasculaires, troubles du système nerveux central et périphérique, maladies liées à la reproduction, maladies urologiques, maladies hématologiques, troubles du système respiratoire ainsi qu'au cancer. Cette invention se rapporte également à des techniques d'identification de composés servant à traiter ou prévenir des maladies cardiovasculaires, troubles du système nerveux central et périphérique, maladies liées à la reproduction, maladies urologiques, maladies hématologiques, troubles du système respiratoire ainsi que le cancer. La présente invention concerne en outre des composés qui se fixent sur ladite PDE7b et/ou stimulent ou inhibent son activité, ainsi que des compositions pharmaceutiques contenant ces composés.
PCT/EP2003/012342 2002-11-13 2003-11-05 Procedes de diagnostic de maladies associees a la phosphodiesterase 7b (pde7b) humaine et moyens therapeutiques correspondants WO2004044196A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03772308A EP1608742A1 (fr) 2002-11-13 2003-11-05 Procedes de diagnostic de maladies associees a la phosphodiesterase 7b (pde7b) humaine et moyens therapeutiques correspondants
AU2003279361A AU2003279361A1 (en) 2002-11-13 2003-11-05 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 7B (PDE7b)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02025502.2 2002-11-13
EP02025502 2002-11-13

Publications (1)

Publication Number Publication Date
WO2004044196A1 true WO2004044196A1 (fr) 2004-05-27

Family

ID=32309335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/012342 WO2004044196A1 (fr) 2002-11-13 2003-11-05 Procedes de diagnostic de maladies associees a la phosphodiesterase 7b (pde7b) humaine et moyens therapeutiques correspondants

Country Status (3)

Country Link
EP (1) EP1608742A1 (fr)
AU (1) AU2003279361A1 (fr)
WO (1) WO2004044196A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008119057A2 (fr) 2007-03-27 2008-10-02 Omeros Corporation Utilisation d'inhibiteurs pde7 dans le traitement des troubles du
WO2012064667A2 (fr) 2010-11-08 2012-05-18 Omeros Corporation Traitement d'addiction et de troubles de contrôle des impulsions au moyen d'inhibiteurs de la pde7
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1018559A1 (fr) * 1998-12-23 2000-07-12 Pfizer Limited Phosphodistérases
US6146876A (en) * 1999-06-11 2000-11-14 Millennium Pharmaceuticals, Inc. 22025, a novel human cyclic nucleotide phosphodiesterase
WO2001062940A2 (fr) * 2000-02-21 2001-08-30 Merck Patent Gmbh Nouveau type de phosphodiesterase 7b
WO2001098471A2 (fr) * 2000-06-22 2001-12-27 Incyte Genomics, Inc. Phosphodiesterases
EP1195435A1 (fr) * 2000-09-28 2002-04-10 Warner-Lambert Company Polypeptides phosphodiesterase 7 tronqués
US20020156064A1 (en) * 2001-03-06 2002-10-24 Smithkline Beecham Corp Compounds and their use as PDE inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1018559A1 (fr) * 1998-12-23 2000-07-12 Pfizer Limited Phosphodistérases
US6146876A (en) * 1999-06-11 2000-11-14 Millennium Pharmaceuticals, Inc. 22025, a novel human cyclic nucleotide phosphodiesterase
WO2000077226A1 (fr) * 1999-06-11 2000-12-21 Millennium Pharmaceuticals, Inc. 22025, nouvelle phosphodiesterase humaine cyclique de nucleotide
WO2001062940A2 (fr) * 2000-02-21 2001-08-30 Merck Patent Gmbh Nouveau type de phosphodiesterase 7b
WO2001098471A2 (fr) * 2000-06-22 2001-12-27 Incyte Genomics, Inc. Phosphodiesterases
EP1195435A1 (fr) * 2000-09-28 2002-04-10 Warner-Lambert Company Polypeptides phosphodiesterase 7 tronqués
US20020156064A1 (en) * 2001-03-06 2002-10-24 Smithkline Beecham Corp Compounds and their use as PDE inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GARDNER CLARE ET AL: "Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 272, no. 1, 27 May 2000 (2000-05-27), pages 186 - 192, XP002272395, ISSN: 0006-291X *
HETMAN J M ET AL: "Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 1, 4 January 2000 (2000-01-04), pages 472 - 476, XP002134917, ISSN: 0027-8424 *
LI L ET AL: "CD3- and CD28-dependent induction of PDE7 required for T cell activation.", SCIENCE. UNITED STATES 5 FEB 1999, vol. 283, no. 5403, 5 February 1999 (1999-02-05), pages 848 - 851, XP002272396, ISSN: 0036-8075 *
SASAKI TAKASHI ET AL: "Identification of human PDE7B, a cAMP-specific phosphodiesterase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 271, no. 3, 19 May 2000 (2000-05-19), pages 575 - 583, XP002151411, ISSN: 0006-291X *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008119057A2 (fr) 2007-03-27 2008-10-02 Omeros Corporation Utilisation d'inhibiteurs pde7 dans le traitement des troubles du
WO2012064667A2 (fr) 2010-11-08 2012-05-18 Omeros Corporation Traitement d'addiction et de troubles de contrôle des impulsions au moyen d'inhibiteurs de la pde7
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US11207275B2 (en) 2010-11-08 2021-12-28 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US11464785B2 (en) 2010-11-08 2022-10-11 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
EP4275752A2 (fr) 2010-11-08 2023-11-15 Omeros Corporation Traitement d'addiction et de troubles de contrôle des impulsions au moyen d'inhibiteurs de la pde7

Also Published As

Publication number Publication date
AU2003279361A1 (en) 2004-06-03
EP1608742A1 (fr) 2005-12-28

Similar Documents

Publication Publication Date Title
US20110033844A1 (en) Use of lysosomal carboxypeptidase c (prcp) as a therapeutic or diagnostic target
EP1597386A1 (fr) Outils de diagnostics et therapeutique pour maladies associees a la phosphodiesterase 2a humaine (pde2a)
WO2004042389A2 (fr) Moyens diagnostiques et therapeutiques destines a des maladies associees a la phosphodiesterase 4d (pde4d) humaine
EP1573331A1 (fr) Diagnostic et traitement de maladies associees a la phosphodiesterase 9a1(pde9a1)humaine
US20070155662A1 (en) Diagnostics and therapeutics for diseases associated with phosphodiesterase 1a (pde1a)
EP1608742A1 (fr) Procedes de diagnostic de maladies associees a la phosphodiesterase 7b (pde7b) humaine et moyens therapeutiques correspondants
US20060166911A1 (en) Diagnostics and therapeutics for diseases associated with human phosphodiesterase 11a (pde11a)
US20060188882A1 (en) Diagnostics and therapeutics for diseases associated with phosphodi-esterase 1c (pde1c)
WO2004044235A1 (fr) Procedes de diagnostic de maladies associees a la phosphodiesterase 7a1 (pde7a1) humaine et moyens therapeutiques correspondants
WO2004053494A1 (fr) Agents de diagnostic et de traitement de maladies associees a la phosphodiesterase humaine 9a2 (pde9a2)
WO2004042390A2 (fr) Diagnostic et therapeutique de maladies associees a la phosphodiesterase 4b (pde4b) humaine
US20060110783A1 (en) Diagnostics and therapeutics for diseases associated with human phosphodiesterase 10a (pde10a)
EP1426767A1 (fr) Diagnostic et traitement pour des maladies associées au phosphodiesterase 4c humain (PDE4C)
WO2004053492A1 (fr) Diagnostic et traitement de maladies associees a la phosphodiesterase 9a3 (pde9a3) humaine
EP1576372A1 (fr) Diagnostic et traitement de maladies associees a la phosphodiesterase 9a4 (pde9a4) humaine
WO2004071377A2 (fr) Methodes diagnostiques et therapeutiques relatives a des etats pathologiques lies a la photodiesterase 3a (pde3a)
EP1601782A2 (fr) Diagnostics et traitements de maladies associees a la phosphodiesterase 8b humaine (pde8b)
US20060281085A1 (en) Diagnostics and therapeutics for diseases associated with phosphodiesterase 1b (pde1b)
EP1604035A2 (fr) Diagnostics et medicaments pour des maladies associees a la phosphodiesterase 8a (pde8a) humaine
WO2004042386A2 (fr) Moyens diagnostiques et therapeutiques destines a des maladies associees a la phosphodiesterase 11a3 (pde11a3) humaine
WO2004044229A2 (fr) Procedes de diagnostic de maladies associees a la phosphodiesterase 7a2 (pde7a2) humaine et moyens therapeutiques correspondants
EP1604034A2 (fr) Diagnostics et traitements de maladies associees a la phosphodiesterase 11a1 humaine (pde11a1)
WO2004075812A2 (fr) Produits diagnostiques et therapeutiques pour des maladies associees a une phosphodiesterase 3b (pde3b)
WO2004082575A2 (fr) Diagnostics et traitements contre des maladies associees au phosphodiesterase 6b (pde6b)
WO2004042076A2 (fr) Diagnostic et therapeutique de maladies associees a la phosphodiesterase 4a (pde4a) humaine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003772308

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003772308

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2003772308

Country of ref document: EP