WO2004037856A3 - Facteur de virulence du var o du plasmodium falciparum - Google Patents

Facteur de virulence du var o du plasmodium falciparum Download PDF

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Publication number
WO2004037856A3
WO2004037856A3 PCT/EP2003/013341 EP0313341W WO2004037856A3 WO 2004037856 A3 WO2004037856 A3 WO 2004037856A3 EP 0313341 W EP0313341 W EP 0313341W WO 2004037856 A3 WO2004037856 A3 WO 2004037856A3
Authority
WO
WIPO (PCT)
Prior art keywords
plasmodium falciparum
var
foregoing
virulence factor
factor var
Prior art date
Application number
PCT/EP2003/013341
Other languages
English (en)
Other versions
WO2004037856A2 (fr
Inventor
Odile Puijalon
Scanf Cecile Le
Anne Lavergne
Graham Bentley
Cyril Badaut
Sebastien Igonet
Original Assignee
Pasteur Institut
Odile Puijalon
Scanf Cecile Le
Anne Lavergne
Graham Bentley
Cyril Badaut
Sebastien Igonet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Odile Puijalon, Scanf Cecile Le, Anne Lavergne, Graham Bentley, Cyril Badaut, Sebastien Igonet filed Critical Pasteur Institut
Priority to AU2003292133A priority Critical patent/AU2003292133A1/en
Publication of WO2004037856A2 publication Critical patent/WO2004037856A2/fr
Publication of WO2004037856A3 publication Critical patent/WO2004037856A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention porte: sur la découverte: du gène var O spécifique de la souche Palo Alto FUP/SP-O du Plasmodium falciparum, de la protéine correspondante, et des adhésines qui médient la formation de rosettes de globules rouges et leur auto-agglutination dans la pathogénie de la malaria. Elle porte en outre sur de nouveaux outils et procédés biologiques utilisant les précédents, dont des molécules d'acide nucléique, des polypeptides, des anticorps, des vecteurs recombinés, des cellules hôtes recombinées, ainsi que sur des applications diagnostiques et thérapeutiques correspondantes des précédents.
PCT/EP2003/013341 2002-10-25 2003-10-24 Facteur de virulence du var o du plasmodium falciparum WO2004037856A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003292133A AU2003292133A1 (en) 2002-10-25 2003-10-24 Plasmodium falciparum virulence factor var o

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002409897A CA2409897A1 (fr) 2002-10-25 2002-10-25 Facteur de virulence var o du plasmodium falciparum
CA2,409,897 2002-10-25

Publications (2)

Publication Number Publication Date
WO2004037856A2 WO2004037856A2 (fr) 2004-05-06
WO2004037856A3 true WO2004037856A3 (fr) 2004-07-29

Family

ID=32111429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/013341 WO2004037856A2 (fr) 2002-10-25 2003-10-24 Facteur de virulence du var o du plasmodium falciparum

Country Status (3)

Country Link
AU (1) AU2003292133A1 (fr)
CA (1) CA2409897A1 (fr)
WO (1) WO2004037856A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102781958B (zh) 2009-12-05 2017-07-11 马尔瓦有限责任公司 基于顶复虫Ferlin、Ferlin样蛋白和其它含有C2结构域的蛋白的疟疾疫苗

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033736A1 (fr) * 1995-04-27 1996-10-31 Affymax Technologies N.V. Peptides du paludisme et vaccins associes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033736A1 (fr) * 1995-04-27 1996-10-31 Affymax Technologies N.V. Peptides du paludisme et vaccins associes

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BARUCH DROR I ET AL: "Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 6, 19 March 2002 (2002-03-19), March 19, 2002, pages 3860 - 3865, XP002279798, ISSN: 0027-8424 *
CHEN Q ET AL: "IDENTIFICATION OF PLASMODIUM FALCIPARUM ERYTHROCYTE MEMBRANE PROTEIN 1 (PFEMP1) AS THE ROSETTING LIGAND OF THE MALARIA PARASITE P.FALCIPARUM", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 187, no. 1, 5 January 1998 (1998-01-05), pages 15 - 23, XP000918017, ISSN: 0022-1007 *
DATABASE EMBL [online] ebi; 12 September 2002 (2002-09-12), TANG K. ET AL.,: "EST from plasmodium falciparum", XP002279719, Database accession no. BU497511 *
DATABASE EMBL [online] EBI; 2 October 2002 (2002-10-02), SEEGER K. ET AL.,: "Plasmodium falciparum chromosome 8", XP002279717, Database accession no. AL844507 *
DATABASE EMBL [online] ebi; 6 June 1997 (1997-06-06), ROWE J.A. ET AL.,: "Plasmodium falciparum R29R+var1 gene, exon 1", XP002279784, Database accession no. Y13402 *
DATABASE EMBL [online] ebi; FRIED M ET AL.,: "plasmodium falciparum isolate PLC12a erythrocyte membrane protein 1 (var)", XP002279718, Database accession no. AF465502 *
DATABASE EMBL [online] ebi; SMITH J.D. ET AL.,: "plasmodium falciparum (clone R29) var mRNA fragment", XP002279720, Database accession no. L42247 *
LE SCANF CECILE ET AL: "Novel target antigens of the variant-specific immune response to Plasmodium falciparum identified by differential screening of an expression library", INFECTION AND IMMUNITY, vol. 67, no. 1, January 1999 (1999-01-01), pages 64 - 73, XP002279712, ISSN: 0019-9567 *
LE SCANF CECILE ET AL: "Plasmodium falciparum: Altered expression of erythrocyte membrane-associated antigens during antigenic variation", EXPERIMENTAL PARASITOLOGY, vol. 85, no. 2, 1997, pages 135 - 148, XP002279713, ISSN: 0014-4894 *
ROWE J ALEXANDRA ET AL: "P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor", NATURE (LONDON), vol. 388, no. 6639, Y13402, 1997, pages 292 - 295, XP002279714, ISSN: 0028-0836 *
SMITH JOSEPH D ET AL: "Classification of adhesive domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 family", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 110, no. 2, October 2000 (2000-10-01), pages 293 - 310, XP002279716, ISSN: 0166-6851 *
SMITH JOSEPH D ET AL: "Decoding the language of var genes and Plasmodium falciparum sequestration", TRENDS IN PARASITOLOGY, vol. 17, no. 11, November 2001 (2001-11-01), pages 538 - 545, XP002279715, ISSN: 1471-4922 *

Also Published As

Publication number Publication date
AU2003292133A8 (en) 2004-05-13
AU2003292133A1 (en) 2004-05-13
WO2004037856A2 (fr) 2004-05-06
CA2409897A1 (fr) 2004-04-25

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