WO2004035824A3 - Procede - Google Patents

Procede Download PDF

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Publication number
WO2004035824A3
WO2004035824A3 PCT/GB2003/004444 GB0304444W WO2004035824A3 WO 2004035824 A3 WO2004035824 A3 WO 2004035824A3 GB 0304444 W GB0304444 W GB 0304444W WO 2004035824 A3 WO2004035824 A3 WO 2004035824A3
Authority
WO
WIPO (PCT)
Prior art keywords
transcriptional activity
detecting polymorphisms
polymorphisms affecting
nucleic acid
affecting transcriptional
Prior art date
Application number
PCT/GB2003/004444
Other languages
English (en)
Other versions
WO2004035824A2 (fr
Inventor
Julian C Knight
Dominic P Kwiatkowski
Original Assignee
Isis Innovation
Julian C Knight
Dominic P Kwiatkowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0224304A external-priority patent/GB0224304D0/en
Priority claimed from GB0304254A external-priority patent/GB0304254D0/en
Application filed by Isis Innovation, Julian C Knight, Dominic P Kwiatkowski filed Critical Isis Innovation
Priority to AU2003278309A priority Critical patent/AU2003278309A1/en
Publication of WO2004035824A2 publication Critical patent/WO2004035824A2/fr
Publication of WO2004035824A3 publication Critical patent/WO2004035824A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés pour déterminer la présence d'un polymorphisme d'acide nucléique permettant de déterminer si un polymorphisme d'acide nucléique affecte le niveau de transcription d'un gène et pour déterminer l'effet d'un polymorphisme d'acide nucléique à un stade spécifique d'activité transcriptionnelle.
PCT/GB2003/004444 2002-10-18 2003-10-16 Procede WO2004035824A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003278309A AU2003278309A1 (en) 2002-10-18 2003-10-16 Method of detecting polymorphisms affecting transcriptional activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0224304.6 2002-10-18
GB0224304A GB0224304D0 (en) 2002-10-18 2002-10-18 Method
GB0304254.6 2003-02-25
GB0304254A GB0304254D0 (en) 2003-02-25 2003-02-25 Method

Publications (2)

Publication Number Publication Date
WO2004035824A2 WO2004035824A2 (fr) 2004-04-29
WO2004035824A3 true WO2004035824A3 (fr) 2004-06-03

Family

ID=32109252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004444 WO2004035824A2 (fr) 2002-10-18 2003-10-16 Procede

Country Status (2)

Country Link
AU (1) AU2003278309A1 (fr)
WO (1) WO2004035824A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056954A1 (fr) * 1997-06-13 1998-12-17 Affymetrix, Inc. Procede de detection de polymorphismes geniques et surveillance d'expression allelique a l'aide d'un ensemble de sondes
US20020039739A1 (en) * 1997-01-13 2002-04-04 Mack David H. Expression monitoring for gene function identification
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039739A1 (en) * 1997-01-13 2002-04-04 Mack David H. Expression monitoring for gene function identification
WO1998056954A1 (fr) * 1997-06-13 1998-12-17 Affymetrix, Inc. Procede de detection de polymorphismes geniques et surveillance d'expression allelique a l'aide d'un ensemble de sondes
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRINKMAN B M N ET AL: "RELEVANCE OF THE TUMOR NECROSIS FACTOR ALPHA (TNFA) - 308 PROMOTER POLYMORPHISM I TNFA GENE REGULATION", JOURNAL OF INFLAMMATION, WILEY-LISS INC., NEW YORK, NY, US, vol. 46, no. 1, 1996, pages 32 - 41, XP000907438, ISSN: 1078-7852 *
HORNSTRA I K ET AL: "IN VIVO FOOTPRINTING AND GENOMIC SEQUENCING BY LIGATION-MEDIATED PCR", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 213, no. 2, 1 September 1993 (1993-09-01), pages 179 - 193, XP000387914, ISSN: 0003-2697 *
KOMURA JUN-ICHIRO ET AL: "In vivo ultraviolet and dimethyl sulfate footprinting of the 5' region of the expressed and silent Xist alleles", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 16, 1997, pages 10975 - 10980, XP002275015, ISSN: 0021-9258 *
WEEKS JOHN R ET AL: "Locus-specific variation in phosphorylation state of RNA polymerase II in-vivo: Correlations with gene activity and transcript processing", GENES AND DEVELOPMENT, vol. 7, no. 12A, 1993, pages 2329 - 2344, XP008029080, ISSN: 0890-9369 *
WILSON A G ET AL: "Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, no. 7, 1 April 1997 (1997-04-01), pages 3195 - 3199, XP002139040, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2004035824A2 (fr) 2004-04-29
AU2003278309A1 (en) 2004-05-04
AU2003278309A8 (en) 2004-05-04

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