WO2004034992A3 - Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles - Google Patents

Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles Download PDF

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Publication number
WO2004034992A3
WO2004034992A3 PCT/US2003/032726 US0332726W WO2004034992A3 WO 2004034992 A3 WO2004034992 A3 WO 2004034992A3 US 0332726 W US0332726 W US 0332726W WO 2004034992 A3 WO2004034992 A3 WO 2004034992A3
Authority
WO
WIPO (PCT)
Prior art keywords
ethylene glycol
micelles
phospholipid
poly
polyene
Prior art date
Application number
PCT/US2003/032726
Other languages
French (fr)
Other versions
WO2004034992A2 (en
Inventor
Glen S Kwon
Original Assignee
Wisconsin Alumni Res Found
Glen S Kwon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found, Glen S Kwon filed Critical Wisconsin Alumni Res Found
Priority to AU2003301409A priority Critical patent/AU2003301409A1/en
Publication of WO2004034992A2 publication Critical patent/WO2004034992A2/en
Publication of WO2004034992A3 publication Critical patent/WO2004034992A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

Amphotericin B (or other hydrophobic compound) is encapsulated in a deaggregated form in micelles of monomethoxy poly(ethylene glycol)-phospholipid (as specifically exemplified, the phospholipid is 1,2 di-stearoyl-sn-glycero-3-phosphatidyl ethanolamine) formed by solvent evaporation. Advantageously, the hydration of the dried drug-polymer film is carried at between about 25 °C and about 80 °C. The micelles can be reconstituted with the Amphotericin B (or other hydrophobic compound) in a deaggregated state and safely used in therapy for fungal infections of humans or animals, especially for systemic fungal infections, or other desired application. The polyene micellar formulations described herein are reduced in toxicity as compared with those polyene formulations in which there is significant occurrence of aggregated polyenes.
PCT/US2003/032726 2002-10-15 2003-10-15 Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles WO2004034992A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003301409A AU2003301409A1 (en) 2002-10-15 2003-10-15 Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41892702P 2002-10-15 2002-10-15
US60/418,927 2002-10-15

Publications (2)

Publication Number Publication Date
WO2004034992A2 WO2004034992A2 (en) 2004-04-29
WO2004034992A3 true WO2004034992A3 (en) 2004-09-30

Family

ID=32107996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032726 WO2004034992A2 (en) 2002-10-15 2003-10-15 Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles

Country Status (3)

Country Link
US (2) US20040116360A1 (en)
AU (1) AU2003301409A1 (en)
WO (1) WO2004034992A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005351A1 (en) * 2002-03-29 2004-01-08 Kwon Glen S. Polymeric micelle formulations of hydrophobic compounds and methods
EP1871343A2 (en) * 2005-04-12 2008-01-02 Wisconsin Alumni Research Foundation Micelle composition of polymer and passenger drug
EP2099408B1 (en) * 2006-11-28 2016-10-05 Wisconsin Alumni Research Foundation Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
US8900562B2 (en) * 2007-01-12 2014-12-02 Wisconsin Alumni Research Foundation Semi-fluorinated block copolymers for delivery of therapeutic agents
US20080248097A1 (en) * 2007-02-26 2008-10-09 Kwon Glen S Polymeric micelles for combination drug delivery
KR20150064232A (en) * 2007-05-25 2015-06-10 더 유니버시티 오브 브리티쉬 콜롬비아 Formulations for the oral administration of therapeutic agents and related methods
US20100210575A1 (en) * 2007-06-29 2010-08-19 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
WO2011038278A2 (en) 2009-09-25 2011-03-31 Wisconsin Alumni Research Foundation Micelle encapsulation of therapeutic agents
WO2011050457A1 (en) 2009-10-26 2011-05-05 The University Of British Columbia Stabilized formulation for oral administration of therapeutic agents and related methods
CN103622906B (en) * 2013-12-03 2017-01-11 沈阳药科大学 High drug-loading capacity amphotericin B polymer composite micelle and preparation method thereof
US20170216486A1 (en) * 2016-01-29 2017-08-03 Genadyne Biotechnologies, Inc. System and Method for Treating a Wound
WO2019160719A1 (en) * 2018-02-15 2019-08-22 Novobiotic Pharmaceuticals, Llc Pharmaceutical compositions comprising teixobactin

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US6322810B1 (en) * 1997-07-14 2001-11-27 Hayat Alkan-Onyuksel Materials and methods for making improved micelle compositions

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US5059591B1 (en) * 1983-05-26 2000-04-25 Liposome Co Inc Drug preparations of reduced toxicity
KR940003548U (en) * 1992-08-14 1994-02-21 김형술 Laundry dryer
US5686110A (en) * 1994-06-02 1997-11-11 Enzon, Inc. Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance
DE69624475T2 (en) * 1995-04-19 2003-05-28 Kazunori Kataoka HETEROTELECHELIC BLOCK COPOLYMERS AND METHOD FOR THE PRODUCTION THEREOF
BR9610053A (en) * 1995-08-10 1999-07-06 Katoaka Kazunori Block polymers having functional groups on both ends
US6020121A (en) * 1995-09-29 2000-02-01 Microcide Pharmaceuticals, Inc. Inhibitors of regulatory pathways
US6217886B1 (en) * 1997-07-14 2001-04-17 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved micelle compositions
IL151314A0 (en) * 2000-02-18 2003-04-10 Eisai Co Ltd Micelles, methods for their preparation and methods for delivery of micelles to patients
US6413537B1 (en) * 2000-03-10 2002-07-02 Wisconsin Alumni Research Foundation Nystatin formulation having reduced toxicity
ES2306785T3 (en) * 2001-11-02 2008-11-16 The Governors Of The University Of Alberta COMPOSITIONS OF MICELAS CONTAINING PEGILATED PHOSPHOLIPIDS AND A PHOTOSENSITIZER.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US6322810B1 (en) * 1997-07-14 2001-11-27 Hayat Alkan-Onyuksel Materials and methods for making improved micelle compositions

Also Published As

Publication number Publication date
US20090148509A1 (en) 2009-06-11
AU2003301409A8 (en) 2004-05-04
US20040116360A1 (en) 2004-06-17
AU2003301409A1 (en) 2004-05-04
WO2004034992A2 (en) 2004-04-29

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