WO2004033623A3 - Animal component free meningococcal polysaccharide fermentation and seedbank development - Google Patents

Animal component free meningococcal polysaccharide fermentation and seedbank development Download PDF

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Publication number
WO2004033623A3
WO2004033623A3 PCT/US2003/015290 US0315290W WO2004033623A3 WO 2004033623 A3 WO2004033623 A3 WO 2004033623A3 US 0315290 W US0315290 W US 0315290W WO 2004033623 A3 WO2004033623 A3 WO 2004033623A3
Authority
WO
WIPO (PCT)
Prior art keywords
seedbank
development
fermentation
component free
meningococcal polysaccharide
Prior art date
Application number
PCT/US2003/015290
Other languages
French (fr)
Other versions
WO2004033623A2 (en
Inventor
Richard C Egen
Lori Ann Fortin
Willie Wei Qiang Sun
Original Assignee
Aventis Pasteur Inc
Richard C Egen
Lori Ann Fortin
Willie Wei Qiang Sun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pasteur Inc, Richard C Egen, Lori Ann Fortin, Willie Wei Qiang Sun filed Critical Aventis Pasteur Inc
Priority to AU2003299501A priority Critical patent/AU2003299501A1/en
Publication of WO2004033623A2 publication Critical patent/WO2004033623A2/en
Publication of WO2004033623A3 publication Critical patent/WO2004033623A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

Animal-free meninge fermentation media and process is developed based upon use of a chemically defined medium. To improve polysaccharide production, fed-batch fermentation is examined using different feed solutions and feeding strategies. A feed solution containing glucose, amino acids, and trace metal elements produces Group A polysaccharide at approximately 3 times the level observed with batch fermentation. This process is used successfully to produce polysaccharides of N. meningitidis serotypes A, C, Y and W-135 and is run reproducibly at the 20L scale and can be scaled to 400L or more.
PCT/US2003/015290 2002-05-16 2003-05-16 Animal component free meningococcal polysaccharide fermentation and seedbank development WO2004033623A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003299501A AU2003299501A1 (en) 2002-05-16 2003-05-16 Animal component free meningococcal polysaccharide fermentation and seedbank development

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38134102P 2002-05-16 2002-05-16
US60/381,341 2002-05-16

Publications (2)

Publication Number Publication Date
WO2004033623A2 WO2004033623A2 (en) 2004-04-22
WO2004033623A3 true WO2004033623A3 (en) 2004-07-15

Family

ID=32093705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/015290 WO2004033623A2 (en) 2002-05-16 2003-05-16 Animal component free meningococcal polysaccharide fermentation and seedbank development

Country Status (2)

Country Link
AU (1) AU2003299501A1 (en)
WO (1) WO2004033623A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0408978D0 (en) 2004-04-22 2004-05-26 Chiron Srl Meningococcal fermentation for preparing conjugate vaccines
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
WO2018045286A1 (en) 2016-09-02 2018-03-08 Sanofi Pasteur, Inc. Neisseria meningitidis vaccine
CN114350571B (en) * 2022-02-09 2024-04-19 广州知易生物科技有限公司 Non-animal-derived culture medium and method for culturing Acremonium muciniphilum by using same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351761A (en) * 1978-05-15 1982-09-28 Research Corporation Purified antigen to test for Neisseria gonorrhoeae antibodies
US4814276A (en) * 1986-04-25 1989-03-21 Becton, Dickinson And Company Selective medium for growth of neisseria
US5494808A (en) * 1994-09-15 1996-02-27 Merck & Co., Inc. Defined medium OMPC fermentation process
WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
US20030068336A1 (en) * 2001-01-23 2003-04-10 Ryall Robert P. Multivalent meningococcal polysaccharide-protein conjugate vaccine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351761A (en) * 1978-05-15 1982-09-28 Research Corporation Purified antigen to test for Neisseria gonorrhoeae antibodies
US4814276A (en) * 1986-04-25 1989-03-21 Becton, Dickinson And Company Selective medium for growth of neisseria
US5494808A (en) * 1994-09-15 1996-02-27 Merck & Co., Inc. Defined medium OMPC fermentation process
WO1998054296A1 (en) * 1997-05-28 1998-12-03 Chiron S.P.A. Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin
US20030068336A1 (en) * 2001-01-23 2003-04-10 Ryall Robert P. Multivalent meningococcal polysaccharide-protein conjugate vaccine

Also Published As

Publication number Publication date
AU2003299501A8 (en) 2004-05-04
WO2004033623A2 (en) 2004-04-22
AU2003299501A1 (en) 2004-05-04

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