WO2004033028A2 - Phototherapy system and device - Google Patents
Phototherapy system and device Download PDFInfo
- Publication number
- WO2004033028A2 WO2004033028A2 PCT/US2003/031767 US0331767W WO2004033028A2 WO 2004033028 A2 WO2004033028 A2 WO 2004033028A2 US 0331767 W US0331767 W US 0331767W WO 2004033028 A2 WO2004033028 A2 WO 2004033028A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- color
- treatment
- hght
- light
- array
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0621—Hyperbilirubinemia, jaundice treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
Definitions
- This invention relates to devices and methods for the phototherapeutic treatment of illness and diseases.
- Phototherapy is a promising clinical tool for the treatment for many conditions, including seasonal affective disorder, bulimia nervosa, herpes, psoriasis, sleep disorders, acne, and skin cancer.
- Phototherapy is especially promising as a treatment for hyperbilirubinemia, a common condition affecting 60-70% of all full-term infants.
- Hyperbilirubinemia is caused by the accumulation of excess bilirubin in the blood and skin of the infant. This excess bilirubin turns the skin and sclera a characteristic yellow color. If left untreated, extreme cases of hyperbilirubinemia can result in neurological insult (kernicterus) or even death.
- a common treatment for hyperbilirubinemia is phototherapy, in which the infant is exposed to light in a range corresponding to the peak absorption spectra for bilirubin (blue-green, 400-520 ran). This light changes the form of the bilirubin to a different isomer that is more readily eliminated by the body.
- LEDs light emitting diodes
- the present invention is a phototherapy system with light sources covering at least two distinct spectral light regions.
- the spectral light region of the first set of light sources is chosen for its phototherapeutic value. This spectral light region, which need not be a continuous part of the spectrum, will be referred to as the "treatment color.”
- the spectral light region of the second set of light sources is chosen for its ability to mitigate any nausea or other discomfort from viewing the treatment color. This spectral light region will be referred to as the "balancing color.”
- the treatment color is blue, and the balancing color is yellow. This embodiment can be used to be treat hyperbilirubinemia.
- Fig. 1. is a perspective view of a device according to the present invention, with a stand.
- Fig. 2. is a perspective view of a device according to the present invention, without a stand, and with the enclosure tilted up to reveal exemplary LED light sources.
- Fig. 3 is a front view of a device according to the present invention, without a stand.
- Fig. 4 is a back view of a device according to the present invention, without a stand.
- Fig 5. is a side view of a device according to the present invention, without a stand.
- Fig. 6 is a side view of a device according to the present invention, without a stand, and with the enclosure tilted up.
- Fig. 7 is a side view of a device according to the present invention, with a stand.
- Figs. 8a and 8b are schematic depictions of exemplary phototherapy arrays according to embodiments of the present invention.
- Fig. 9 is a chromatidty table.
- the present invention is a phototherapy system and device, including (i) an optional stand 10, (ii) an enclosure 30, and (iii) an array of light sources 40 in the enclosure 30.
- the array includes treatment color light sources (such as blue) and balancing color light sources (such as yellow).
- the optional stand 10 is used to hold the light sources over the subject.
- the stand 10 may have wheels 12, a vertical extension 14, and a horizontal extension 16. It may also have height control means 18 to raise or lower the enclosure 30, and horizontal positioning means 20 to control the horizontal position of the enclosure 30.
- the stand is optional, and other means can be used to hold the array of lights over the subject. For instance, the array can be clipped or fastened over a bassinet, incubator or bed. Depending on the light source used, the array 40 can be distant or very close to the subject.
- the enclosure 30 can be mounted on the stand so that it can be easily tilted. (See Fig. 6).
- the enclosure 30 simply provides structural support for the sockets or board which hold the array of light sources 40.
- Fig. 2 shows the enclosure 30 with an LED board 42.
- "enclosure” is defined to mean any structure that holds the light sources.
- at the back of the enclosure there is an exhaust 32, a power entry module 34, attachment plate 36 to attach the enclosure to the stand 10, an air inlet 38, and a top surface 39.
- the top surface 39 may angled to discourage the placement of spillable liquids on the top of the device.
- the enclosure can be made of many materials, including but not limited to metal or various kinds of plastic or polyvinyl materials. Typically, the enclosure will be a rigid structure. However, it is possible to use a flexible enclosure to be used in embodiments in which the enclosure is wrapped around the subject.
- the array of light sources 40 is a plurality of band-limited light sources, such as semiconductor light sources, LEDs 42, halogen lights, low-intensity lasers, etc.
- the array can take a number of different forms, and the distribution of lights in the array can be uniform or nonuniform.
- Switches are used to control the light sources, and in one embodiment, a switch 44 can provide for operation in either a high or low intensity mode.
- a potentiometer could be added to provide more precise control or to provide a wider range of light intensity.
- diffusers and other optical intensity adjustment devices can be used to adjust the intensity of the light.
- an "optical intensity adjustment .device" is any device that can alter the intensity of emitted light.
- the array includes light sources covering at least two different spectral light regions. See Fig. 8.
- the first spectral light region - the treatment color — is chosen for its phototherapeutic value.
- the treatment color can be blue, for use in treating hyperbilirubinemia.
- Other exemplary treatment colors include fed for treatment of psoriasis.
- the second spectral light region - the balancing color is chosen for its ability to modify perception of the treatment color and thereby mitigate the nausea or other negative effects that result from viewing the treatment color. For instance, some healthcare workers have reported nausea from exposure to blue light LEDs. It has been found through trial and error that interspersing yellow LEDs into an array of blue LEDs mitigates or eliminates that effect. Yellow light seems to relieve blue light nausea better than other colors. For purposes of this patent, “blue” light is in the range of 400 ran to 520 ran, and "yellow” light is in the range of 547 nm to 619 ran. Green, red, or orange light sources can also be used for the balancing color when blue light is used for the treatment light
- the " balancing color can be determined by experimentation to gauge what color most effectively relieves the symptoms caused by the treatment color.
- the balancing color may be the spectral light range that produces a perception of white or non-treatment color when combined with the treatment color.
- a chromaticity table such as the one provided as Figure 9, can be used to find the appropriate balancing color, by drawing a line from the treatment color through the central point indicating white light, and then determining where the line intersects the color line.
- balancing colors can be also used.
- red and yellow light can be used to balance the blue light used to treat hyperbilirubinemia.
- intensity of the balancing color or colors can be adjusted to achieve the desired effect.
- a sufficient amount of balancing color light is required.
- a ratio of about 3 blue LEDs to 1 yellow LEDs of equal intensity has been found sufficient.
- the appropriate ratio will depend on a number of factors, including the intensity of both the treatment LEDs and the balancing LEDs, and on the color perception that is sought.
- the balancing color light sources can be arranged in the array in a number of ways, including random distribution, various uniform distributions, distribution about the periphery of the array, and even placement in a separate array or enclosure.
- Exemplary arrays are provided in Figures 8a and 8b. In these figures, a target light of red LEDs is also shown,
- narrow-band or limited spectral range light sources including semiconductor light sources, LEDs and low-intensity lasers.
- limited spectral range light source will be used to generically refer to any light source that emits light from any spectral range except the range that includes all visible colors, i.e. white light.
- approximately 1000 blue-green (420 - 500 nm) LEDs can be used to treat hyperbilirubinemia, along with 320 yellow LEDs.
- Such LEDs are commercially available from CREE, Inc. (4600 Silicon Drive, Durham, NC 27703) and Nichia America Corporation (3775 Hempland Road, Mountville, Pennsylvania 17554).
- the number of light sources in the array will vary based on their intensity and on the nature of the phototherapeutic treatment.
- the light sources 40 would shine down on the subject. However, they can also be oriented upwards, and bounce off an optional reflector on the enclosure. Such a reflector can be curved into a convex formation, to diffuse the light away from the center of the subject, or to otherwise alter the intensity, distribution, or light properties of the array.
- the light sources can be arranged to shine from the side, such as through a transparent bassinet, or from the bottom, or any combination thereof.
- Both the treatment color light sources and the balancing color light sources may be illuminated continuously or discontinuously, and the present invention is not Hmited by the duration, frequency, or pattern of illumination for either or both set of light sources.
- the lights may illuminated synchronously, asynchronously, in a staggered manner, in a random manner, or in accordance with a predefined frequency or duty cycle (ratio of illuminated time to non-illuminated time). In one embodiment, a duty cycle of below 0.5 is used.
- the subject may be placed under the phototherapy device, and both the treatment color and balancing color light sources may be iUuminated simultaneously.
- the subject will then receive phototherapy, and the healthcare workers admiriistering the treatment may not feel the nausea that sometimes results from exposure to a single color light such as blue.
- the balancing color changes the perception of the health care workers so that instead of perceiving only the treatment color, the workers perceive a blended, balanced, or alternative color.
- the intensity of the balancing color can be adjusted as necessary to achieve the desired balanced or altered perception.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003282748A AU2003282748A1 (en) | 2002-10-07 | 2003-10-07 | Phototherapy system and device |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/265,970 | 2002-10-07 | ||
US10/265,970 US7131990B2 (en) | 2002-10-07 | 2002-10-07 | Phototherapy system and device |
US10/651,906 | 2003-08-29 | ||
US10/651,906 US7438719B2 (en) | 2002-10-07 | 2003-08-29 | Phototherapy system and device |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004033028A2 true WO2004033028A2 (en) | 2004-04-22 |
WO2004033028A3 WO2004033028A3 (en) | 2004-05-13 |
Family
ID=32095663
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/031768 WO2004033029A2 (en) | 2002-10-07 | 2003-10-07 | Phototherapy system and device |
PCT/US2003/031767 WO2004033028A2 (en) | 2002-10-07 | 2003-10-07 | Phototherapy system and device |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/031768 WO2004033029A2 (en) | 2002-10-07 | 2003-10-07 | Phototherapy system and device |
Country Status (2)
Country | Link |
---|---|
AU (2) | AU2003282748A1 (en) |
WO (2) | WO2004033029A2 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005025671A1 (en) * | 2003-09-17 | 2005-03-24 | Djalma Luiz Rodrigues | A phototherapy equipment, particularly for the treatment of hyperbilirubinemia |
WO2009056838A1 (en) * | 2007-10-31 | 2009-05-07 | University Of Strathclyde | Lighting device |
US9333274B2 (en) | 2014-07-31 | 2016-05-10 | Vital Vio, Inc. | Disinfecting light fixture |
US9439989B2 (en) | 2014-07-31 | 2016-09-13 | Vital Vio, Inc. | Disinfecting light fixture |
US9927097B2 (en) | 2015-07-30 | 2018-03-27 | Vital Vio Inc. | Single diode disinfection |
US10309614B1 (en) | 2017-12-05 | 2019-06-04 | Vital Vivo, Inc. | Light directing element |
US10357582B1 (en) | 2015-07-30 | 2019-07-23 | Vital Vio, Inc. | Disinfecting lighting device |
US10363325B2 (en) | 2015-06-26 | 2019-07-30 | Kenall Manufacturing Company | Lighting device that deactivates dangerous pathogens while providing visually appealing light |
US10413626B1 (en) | 2018-03-29 | 2019-09-17 | Vital Vio, Inc. | Multiple light emitter for inactivating microorganisms |
US10456485B1 (en) | 2015-06-26 | 2019-10-29 | Kenall Manufacturing Company | Single-emitter lighting device that outputs a minimum amount of power to produce integrated radiance values sufficient for deactivating pathogens |
US10617774B2 (en) | 2017-12-01 | 2020-04-14 | Vital Vio, Inc. | Cover with disinfecting illuminated surface |
US10918747B2 (en) | 2015-07-30 | 2021-02-16 | Vital Vio, Inc. | Disinfecting lighting device |
US10953117B2 (en) | 2005-07-29 | 2021-03-23 | University Of Strathclyde | Inactivation of gram-positive bacteria |
US11273324B2 (en) | 2015-07-14 | 2022-03-15 | Illumipure Corp | LED structure and luminaire for continuous disinfection |
US11369704B2 (en) | 2019-08-15 | 2022-06-28 | Vyv, Inc. | Devices configured to disinfect interiors |
US11499707B2 (en) | 2020-04-13 | 2022-11-15 | Calyxpure, Inc. | Light fixture having a fan and ultraviolet sterilization functionality |
US11541135B2 (en) | 2019-06-28 | 2023-01-03 | Vyv, Inc. | Multiple band visible light disinfection |
US11639897B2 (en) | 2019-03-29 | 2023-05-02 | Vyv, Inc. | Contamination load sensing device |
US11759540B2 (en) | 2021-05-11 | 2023-09-19 | Calyxpure, Inc. | Portable disinfection unit |
US11878084B2 (en) | 2019-09-20 | 2024-01-23 | Vyv, Inc. | Disinfecting light emitting subcomponent |
Citations (4)
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US6045575A (en) * | 1997-09-10 | 2000-04-04 | Amt, Inc. | Therapeutic method and internally illuminated garment for the management of disorders treatable by phototherapy |
US6166496A (en) * | 1997-08-26 | 2000-12-26 | Color Kinetics Incorporated | Lighting entertainment system |
US6290713B1 (en) * | 1999-08-24 | 2001-09-18 | Thomas A. Russell | Flexible illuminators for phototherapy |
US6596016B1 (en) * | 1997-03-27 | 2003-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Phototherapy of jaundiced newborns using garments containing semiconductor light-emitting devices |
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US5299109A (en) * | 1992-11-10 | 1994-03-29 | High Lites, Inc. | LED exit light fixture |
JP3866858B2 (en) * | 1998-04-30 | 2007-01-10 | 株式会社ニデック | Laser therapy device |
US6414801B1 (en) * | 1999-01-14 | 2002-07-02 | Truck-Lite Co., Inc. | Catadioptric light emitting diode assembly |
-
2003
- 2003-10-07 WO PCT/US2003/031768 patent/WO2004033029A2/en not_active Application Discontinuation
- 2003-10-07 AU AU2003282748A patent/AU2003282748A1/en not_active Abandoned
- 2003-10-07 WO PCT/US2003/031767 patent/WO2004033028A2/en not_active Application Discontinuation
- 2003-10-07 AU AU2003279168A patent/AU2003279168A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6596016B1 (en) * | 1997-03-27 | 2003-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Phototherapy of jaundiced newborns using garments containing semiconductor light-emitting devices |
US6166496A (en) * | 1997-08-26 | 2000-12-26 | Color Kinetics Incorporated | Lighting entertainment system |
US6045575A (en) * | 1997-09-10 | 2000-04-04 | Amt, Inc. | Therapeutic method and internally illuminated garment for the management of disorders treatable by phototherapy |
US6290713B1 (en) * | 1999-08-24 | 2001-09-18 | Thomas A. Russell | Flexible illuminators for phototherapy |
Cited By (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005025671A1 (en) * | 2003-09-17 | 2005-03-24 | Djalma Luiz Rodrigues | A phototherapy equipment, particularly for the treatment of hyperbilirubinemia |
US8202307B2 (en) | 2003-09-17 | 2012-06-19 | Djalma Luiz Rodrigues | Phototherapy equipment for the treatment of hyperbilirubinemia and other diseases |
US11730838B2 (en) | 2005-07-29 | 2023-08-22 | University Of Strathclyde | Inactivation of gram-positive bacteria |
US10953117B2 (en) | 2005-07-29 | 2021-03-23 | University Of Strathclyde | Inactivation of gram-positive bacteria |
WO2009056838A1 (en) * | 2007-10-31 | 2009-05-07 | University Of Strathclyde | Lighting device |
US8398264B2 (en) | 2007-10-31 | 2013-03-19 | University Of Strathclyde | Lighting device |
US9333274B2 (en) | 2014-07-31 | 2016-05-10 | Vital Vio, Inc. | Disinfecting light fixture |
US9439989B2 (en) | 2014-07-31 | 2016-09-13 | Vital Vio, Inc. | Disinfecting light fixture |
US10823369B2 (en) | 2015-06-26 | 2020-11-03 | Kenall Manufacturing Company | Lighting device that deactivates dangerous pathogens while providing visually appealing light |
US11054109B2 (en) | 2015-06-26 | 2021-07-06 | Kenall Manufacturing Company | Single-emitter lighting device that outputs a minimum amount of power to produce integrated radiance values sufficient for deactivating pathogens |
US11493183B2 (en) | 2015-06-26 | 2022-11-08 | Kenall Manufacturing Company | Method of providing doses of light sufficient to deactivate dangerous pathogens throughout a volumetric space over a period of time |
US10434202B2 (en) | 2015-06-26 | 2019-10-08 | Kenall Manufacturing Company | Lighting device that deactivates dangerous pathogens while providing visually appealing light |
US10456485B1 (en) | 2015-06-26 | 2019-10-29 | Kenall Manufacturing Company | Single-emitter lighting device that outputs a minimum amount of power to produce integrated radiance values sufficient for deactivating pathogens |
US11324843B2 (en) | 2015-06-26 | 2022-05-10 | Kenall Manufacturing Company | Lighting device that deactivates dangerous pathogens while providing visually appealing light |
US10617775B2 (en) | 2015-06-26 | 2020-04-14 | Kenall Manufacturing Company | Lighting device that deactivates dangerous pathogens while providing visually appealing light |
US10363325B2 (en) | 2015-06-26 | 2019-07-30 | Kenall Manufacturing Company | Lighting device that deactivates dangerous pathogens while providing visually appealing light |
US10765765B2 (en) | 2015-06-26 | 2020-09-08 | Kenall Manufacturing Company | Single-emitter lighting device that outputs a minimum amount of power to produce integrated radiance values sufficient for deactivating pathogens |
US11054110B2 (en) | 2015-06-26 | 2021-07-06 | Kenall Manufacturing Company | Single-emitter lighting device that outputs a minimum amount of power to produce integrated radiance values sufficient for deactivating pathogens |
US11273324B2 (en) | 2015-07-14 | 2022-03-15 | Illumipure Corp | LED structure and luminaire for continuous disinfection |
US11713851B2 (en) | 2015-07-30 | 2023-08-01 | Vyv, Inc. | Single diode disinfection |
US10918747B2 (en) | 2015-07-30 | 2021-02-16 | Vital Vio, Inc. | Disinfecting lighting device |
US10753575B2 (en) | 2015-07-30 | 2020-08-25 | Vital Vio, Inc. | Single diode disinfection |
US12018801B2 (en) | 2015-07-30 | 2024-06-25 | Vyv, Inc. | Single diode disinfection |
US9927097B2 (en) | 2015-07-30 | 2018-03-27 | Vital Vio Inc. | Single diode disinfection |
US10357582B1 (en) | 2015-07-30 | 2019-07-23 | Vital Vio, Inc. | Disinfecting lighting device |
US10835627B2 (en) | 2017-12-01 | 2020-11-17 | Vital Vio, Inc. | Devices using flexible light emitting layer for creating disinfecting illuminated surface, and related method |
US10617774B2 (en) | 2017-12-01 | 2020-04-14 | Vital Vio, Inc. | Cover with disinfecting illuminated surface |
US11426474B2 (en) | 2017-12-01 | 2022-08-30 | Vyv, Inc. | Devices using flexible light emitting layer for creating disinfecting illuminated surface, and related methods |
US10309614B1 (en) | 2017-12-05 | 2019-06-04 | Vital Vivo, Inc. | Light directing element |
US10806812B2 (en) | 2018-03-29 | 2020-10-20 | Vital Vio, Inc. | Multiple light emitter for inactivating microorganisms |
US10413626B1 (en) | 2018-03-29 | 2019-09-17 | Vital Vio, Inc. | Multiple light emitter for inactivating microorganisms |
US11395858B2 (en) | 2018-03-29 | 2022-07-26 | Vyv, Inc. | Multiple light emitter for inactivating microorganisms |
US11639897B2 (en) | 2019-03-29 | 2023-05-02 | Vyv, Inc. | Contamination load sensing device |
US11541135B2 (en) | 2019-06-28 | 2023-01-03 | Vyv, Inc. | Multiple band visible light disinfection |
US11717583B2 (en) | 2019-08-15 | 2023-08-08 | Vyv, Inc. | Devices configured to disinfect interiors |
US11369704B2 (en) | 2019-08-15 | 2022-06-28 | Vyv, Inc. | Devices configured to disinfect interiors |
US11878084B2 (en) | 2019-09-20 | 2024-01-23 | Vyv, Inc. | Disinfecting light emitting subcomponent |
US11499707B2 (en) | 2020-04-13 | 2022-11-15 | Calyxpure, Inc. | Light fixture having a fan and ultraviolet sterilization functionality |
US11759540B2 (en) | 2021-05-11 | 2023-09-19 | Calyxpure, Inc. | Portable disinfection unit |
Also Published As
Publication number | Publication date |
---|---|
AU2003282748A1 (en) | 2004-05-04 |
AU2003279168A1 (en) | 2004-05-04 |
WO2004033029A2 (en) | 2004-04-22 |
AU2003282748A8 (en) | 2004-05-04 |
AU2003279168A8 (en) | 2004-05-04 |
WO2004033028A3 (en) | 2004-05-13 |
WO2004033029A3 (en) | 2004-06-24 |
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