WO2004031359A3 - Method for regulating expression genes - Google Patents

Method for regulating expression genes Download PDF

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Publication number
WO2004031359A3
WO2004031359A3 PCT/US2003/031306 US0331306W WO2004031359A3 WO 2004031359 A3 WO2004031359 A3 WO 2004031359A3 US 0331306 W US0331306 W US 0331306W WO 2004031359 A3 WO2004031359 A3 WO 2004031359A3
Authority
WO
WIPO (PCT)
Prior art keywords
transfected
genes
gene
sense
cell line
Prior art date
Application number
PCT/US2003/031306
Other languages
French (fr)
Other versions
WO2004031359A2 (en
Inventor
Abraham Hochberg
Suhail Ayesh
Enrique Poradosu
Original Assignee
Yissum Res And Dev
Mcinnis Patricia
Abraham Hochberg
Suhail Ayesh
Enrique Poradosu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res And Dev, Mcinnis Patricia, Abraham Hochberg, Suhail Ayesh, Enrique Poradosu filed Critical Yissum Res And Dev
Priority to AU2003291631A priority Critical patent/AU2003291631A1/en
Publication of WO2004031359A2 publication Critical patent/WO2004031359A2/en
Publication of WO2004031359A3 publication Critical patent/WO2004031359A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A bladder carcinoma cell line, which endogenously does not express H19 RNA, shows a marked difference in gene-expression patterns when transfected with H19 sense, as compared with the gene-expression patterns of the same cell line, when transfected with the H19 antisense. In particular, the expression pattern with cells transfected with the H19 sense, showed a marked increase in two unique groups of genes: one group that controls angiogenesis, and another group of genes which protects cells against ischemic stress.
PCT/US2003/031306 2002-10-03 2003-10-03 Method for regulating expression genes WO2004031359A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003291631A AU2003291631A1 (en) 2002-10-03 2003-10-03 Method for regulating expression genes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41552802P 2002-10-03 2002-10-03
US60/415,528 2002-10-03

Publications (2)

Publication Number Publication Date
WO2004031359A2 WO2004031359A2 (en) 2004-04-15
WO2004031359A3 true WO2004031359A3 (en) 2004-12-02

Family

ID=32069877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031306 WO2004031359A2 (en) 2002-10-03 2003-10-03 Method for regulating expression genes

Country Status (2)

Country Link
AU (1) AU2003291631A1 (en)
WO (1) WO2004031359A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067574B2 (en) 2005-07-07 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating H19, and methods of using same

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7928083B2 (en) 2007-01-16 2011-04-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem H19 silencing nucleic acid agents for treating rheumatoid arthritis
BRPI0818937B8 (en) 2007-10-25 2021-05-25 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd constructs containing multiple expression cassettes for cancer therapy
GB201007159D0 (en) * 2010-04-29 2010-06-09 Nhs Blood & Transplant Method for evaluating anglogenic potential
ITMI20101030A1 (en) * 2010-06-09 2011-12-10 Sergio Capaccioli USE OF ANTISENSE OLIGONUCLEOTIDS FOR THE TREATMENT OF RETINAL DEGENERATIONS AND NEOPLASES
PL3134526T3 (en) * 2014-04-22 2019-04-30 Medizinische Hochschule Hannover Lncrnas for therapy and diagnosis of cardiac hypertrophy
WO2016162807A1 (en) * 2015-04-10 2016-10-13 Universita' Degli Studi Di Palermo Microrna inhibitor for the treatment of aberrant angiogenesis and pathologies accompanied thereby
CN111487398B (en) * 2019-01-25 2022-11-11 四川大学华西医院 Biomarkers for hemangioma treatment

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADRIAENSSENS ET AL: "Steroid hormones modulate H19 gene expression in both mammary gland and uterus", ONCOGENE, vol. 18, August 1999 (1999-08-01), pages 4460 - 4473, XP002981363 *
ELKIN ET AL: "Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone", CANCER RES., vol. 59, 15 August 1999 (1999-08-15), pages 4111 - 4118, XP002981364 *
HAN ET AL: "H19, a marker of developmental transition, is reexpressed in human atherosclerotic plaques and is regulated by the insulin family of growth factors in cultured rabbit smooth muscle cells", J. CLIN. INVEST., vol. 97, no. 5, March 1996 (1996-03-01), pages 1276 - 1285, XP002981365 *
HAO ET AL: "Tumour-suppressor activity of H19 RNA", NATURE, vol. 365, 21 October 1993 (1993-10-21), pages 764 - 767, XP001152692 *
JUAN ET AL: "Evidence for evolutionarily conserved secondary structure in the H19 tumor suppressor RNA", NUCLEIC ACIDS RES., vol. 28, no. 5, March 2000 (2000-03-01), pages 1221 - 1227, XP002981367 *
LOTTIN ET AL: "Thioredoxin post-transcriptional regulation by H19 provides a new function to mRNA-like non-coding RNA", ONCOGENE, vol. 21, February 2002 (2002-02-01), pages 1625 - 1631, XP002981366 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067574B2 (en) 2005-07-07 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating H19, and methods of using same
US8067573B2 (en) 2005-07-07 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acid agents for downregulating H19 and methods of using same

Also Published As

Publication number Publication date
WO2004031359A2 (en) 2004-04-15
AU2003291631A8 (en) 2004-04-23
AU2003291631A1 (en) 2004-04-23

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