WO2004029094B1 - Monoclonal antibody specific for human mitochondrial adenylate kinase isozyme 3 - Google Patents

Monoclonal antibody specific for human mitochondrial adenylate kinase isozyme 3

Info

Publication number
WO2004029094B1
WO2004029094B1 PCT/KR2003/001979 KR0301979W WO2004029094B1 WO 2004029094 B1 WO2004029094 B1 WO 2004029094B1 KR 0301979 W KR0301979 W KR 0301979W WO 2004029094 B1 WO2004029094 B1 WO 2004029094B1
Authority
WO
WIPO (PCT)
Prior art keywords
monoclonal antibody
heart disease
detecting
seq
complex formation
Prior art date
Application number
PCT/KR2003/001979
Other languages
French (fr)
Other versions
WO2004029094A1 (en
Inventor
Hyo-Joon Kim
Original Assignee
Hyo-Joon Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyo-Joon Kim filed Critical Hyo-Joon Kim
Priority to AU2003264980A priority Critical patent/AU2003264980A1/en
Publication of WO2004029094A1 publication Critical patent/WO2004029094A1/en
Publication of WO2004029094B1 publication Critical patent/WO2004029094B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04003—Adenylate kinase (2.7.4.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Disclosed are monoclonal antibodies specific for human mitochondrial adenylate kinase isozyme 3 (AK3), a composition and a kit comprising the monoclonal antibodies for the diagnosis of heart disease, and a method of detecting a heart disease marker AK3 using such a composition or kit.

Claims

AMENDED CLAIMS[received by the International Bureau on 08 March 2004 (08.03.04); original claims 1 and 3 amended; original claim 2 cancelled; remaining claims unchanged (3 pages)]
1. (amended) A monoclonal antibody specific to adenylate kinase isozyme 3, comprising 6 complementarity determining regions (CDRs) of a group selected from (a) SEQ ID Nos: 41 to 46, (b) SEQ ID Nos: 47 to 52, (c) SEQ ID Nos: 53 to 58, (d) SEQ ID Nos: 59 to 64, (e) SEQ ID Nos: 65 to 70, (f) SEQ ID
Nos: 71 to 76, (g) SEQ ID Nos: 77 to 82, (h) SEQ ID Nos: 83 to 88 and (i) SEQ ID Nos: 89 to 94.
2. (cancelled)
3. (amended) The monoclonal antibody as set forth in claim 1, wherein the monoclonal antibody is produced by a hybridoma selected from the group consisting of accession numbers KCLRF-BP-00058 to KCLRF-BP-00066.
4. A composition comprising the monoclonal antibody of the claim 1 for detecting a heart disease marker AK3.
5. A kit comprising the monoclonal antibody of the claim 1 for the diagnosis of heart disease.
6. A method of detecting a heart disease marker AK3, comprising the steps of treating a biological sample with the monoclonal antibody of the claim 1 and detecting antigen-antibody complex formation.
7. The method as set forth in claim 6, wherein the antigen-antibody complex formation is detected by ELIS A.
8. The method as set forth in claim 7, wherein the antigen-antibody complex formation is detected by sandwich ELIS A.
48
9. A monoclonal antibody specific to mitochondrial adenylate kinase isozyme 3, recognizing peptides of SEQ ID Nos: 102 to 106.
10. A composition comprising the monoclonal antibody of the claim 9 for detecting a heart disease marker AK3.
11. A kit comprising the monoclonal antibody of the claim 9 for the diagnosis of heart disease.
12. A method of detecting a heart disease marker, comprising the steps of treating a biological sample with the monoclonal antibody of the claim 9 and detecting antigen-antibody complex formation.
13. The method as set forth in claim 12, wherein the antig'en-antibody complex formation is detected by ELIS A.
14. The method as set forth in claim 13, wherein the antigen-antibody complex formation is detected by sandwich ELIS A.
15. A monoclonal antibody specific to mitochondrial adenylate kinase isozyme 3, recognizing a peptide of SEQ ID No: 107.
16. A composition comprising the monoclonal antibody of the claim 15 for detecting a heart disease marker AK3.
17. A kit comprising the monoclonal antibody of the claim 15 for the diagnosis of heart disease.
18. A method of detecting a heart disease marker AK3, comprising the
49 steps of treating a biological sample with the monoclonal antibody of the claim 15 and detecting antigen-antibody complex formation.
19. The method as set forth in claim 18, wherein the antigen-antibody complex formation is detected by ELISA.
20. The method as set forth in claim 19, wherein the antigen-antibody complex formation is detected by sandwich ELISA.
21. A monoclonal antibody with an epitopic specificity identical to a monoclonal antibody produced by a hybridoma cell selected from the group consisting of accession numbers KCLRF-BP-00058 to KCLRF-BP-00066.
22. A composition comprising the monoclonal antibody of the claim 21 for detecting a heart disease marker AK3.
23. A kit comprising the monoclonal antibody of the claim 21 for the diagnosis of heart disease.
24. A method of detecting a heart disease marker AK3, comprising the steps of treating a biological sample with the monoclonal antibody of the claim 21 and detecting antigen-antibody complex formation.
25. The method as set forth in claim 24, wherein the antigen-antibody complex formation is detected by ELISA.
26. The method as set forth in claim 25, wherein the antigen-antibody complex formation is detected by sandwich ELISA.
50
PCT/KR2003/001979 2002-09-28 2003-09-27 Monoclonal antibody specific for human mitochondrial adenylate kinase isozyme 3 WO2004029094A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003264980A AU2003264980A1 (en) 2002-09-28 2003-09-27 Monoclonal antibody specific for human mitochondrial adenylate kinase isozyme 3

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0059211 2002-09-28
KR20020059211 2002-09-28

Publications (2)

Publication Number Publication Date
WO2004029094A1 WO2004029094A1 (en) 2004-04-08
WO2004029094B1 true WO2004029094B1 (en) 2004-06-24

Family

ID=32040942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2003/001979 WO2004029094A1 (en) 2002-09-28 2003-09-27 Monoclonal antibody specific for human mitochondrial adenylate kinase isozyme 3

Country Status (3)

Country Link
KR (1) KR100456790B1 (en)
AU (1) AU2003264980A1 (en)
WO (1) WO2004029094A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010001307A (en) 2007-08-02 2010-07-30 Novimmune Sa Anti-rantes antibodies and methods of use thereof.
WO2010019702A2 (en) * 2008-08-12 2010-02-18 Oncomed Pharmaceuticals, Inc. Ddr1-binding agents and methods of use thereof
WO2020132654A1 (en) * 2018-12-20 2020-06-25 Albert Einstein College Of Medicine Antagonist antibodies against human immune checkpoint ceacam1 (cd66a) and formulations, kits, and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856160A (en) * 1997-03-31 1999-01-05 Incyte Pharmaceuticals, Inc. Mitochondrial adenylate kinase
KR100414637B1 (en) * 2000-02-08 2004-01-13 (주)에스제이바이오메드 Anti-human mitochondrial adenylate kinase isozyme antibody, diagnostic formulation and diagnositc kit for cardiac disease

Also Published As

Publication number Publication date
AU2003264980A1 (en) 2004-04-19
KR100456790B1 (en) 2004-11-10
KR20040028538A (en) 2004-04-03
WO2004029094A1 (en) 2004-04-08

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