WO2004028259A3 - Procedde de stabilisation de molecules bioactives - Google Patents

Procedde de stabilisation de molecules bioactives Download PDF

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Publication number
WO2004028259A3
WO2004028259A3 PCT/EP2003/010699 EP0310699W WO2004028259A3 WO 2004028259 A3 WO2004028259 A3 WO 2004028259A3 EP 0310699 W EP0310699 W EP 0310699W WO 2004028259 A3 WO2004028259 A3 WO 2004028259A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioactive molecules
molecules
stabilizing
stabilizing bioactive
proteins
Prior art date
Application number
PCT/EP2003/010699
Other languages
English (en)
Other versions
WO2004028259A2 (fr
Inventor
Silva Barbesti
Francesco Cipriani
Original Assignee
Bio D S R L
Silva Barbesti
Francesco Cipriani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio D S R L, Silva Barbesti, Francesco Cipriani filed Critical Bio D S R L
Priority to AP2005003253A priority Critical patent/AP2005003253A0/xx
Priority to AU2003271642A priority patent/AU2003271642A1/en
Publication of WO2004028259A2 publication Critical patent/WO2004028259A2/fr
Publication of WO2004028259A3 publication Critical patent/WO2004028259A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de molécules stabilisées, sous forme déshydratée. Le procédé permet la préparation de molécules, notamment de protéines et plus particulièrement d'anticorps, que l'on peut stocker dans des conditions environnementales défavorables, à savoir lors de fluctuations de la température et à des températures élevées.
PCT/EP2003/010699 2002-09-24 2003-09-23 Procedde de stabilisation de molecules bioactives WO2004028259A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AP2005003253A AP2005003253A0 (en) 2002-09-24 2003-09-23 A method for stabilizing bioactive molecules.
AU2003271642A AU2003271642A1 (en) 2002-09-24 2003-09-23 A method for stabilizing bioactive molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBA2002A000032 2002-09-24
IT000032A ITBA20020032A1 (it) 2002-09-24 2002-09-24 Metodo per stabilizzare le proteine per la conservazione ad alte temperature.

Publications (2)

Publication Number Publication Date
WO2004028259A2 WO2004028259A2 (fr) 2004-04-08
WO2004028259A3 true WO2004028259A3 (fr) 2004-05-27

Family

ID=32040241

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/010699 WO2004028259A2 (fr) 2002-09-24 2003-09-23 Procedde de stabilisation de molecules bioactives

Country Status (5)

Country Link
AP (1) AP2005003253A0 (fr)
AU (1) AU2003271642A1 (fr)
IT (1) ITBA20020032A1 (fr)
OA (1) OA12935A (fr)
WO (1) WO2004028259A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010142A1 (fr) * 1988-04-29 1989-11-02 Igen, Inc. Systeme d'interaction comprenant une phase aqueuse dispersee stabilisee par tensio-actif contenant un anticorps ou un fragment d'anticorps
WO1995025119A1 (fr) * 1994-03-16 1995-09-21 Mallinckrodt Medical, Inc. Stabilisation de peptides et de proteines dans le but d'une utilisation radiopharmaceutique
EP0988861A1 (fr) * 1998-08-17 2000-03-29 Pfizer Products Inc. Composition de protéines stabilisée
EP1136068A2 (fr) * 2000-03-21 2001-09-26 Jcr Pharmaceuticals Co., Ltd. Poudre de peptide à activité physiologique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010142A1 (fr) * 1988-04-29 1989-11-02 Igen, Inc. Systeme d'interaction comprenant une phase aqueuse dispersee stabilisee par tensio-actif contenant un anticorps ou un fragment d'anticorps
WO1995025119A1 (fr) * 1994-03-16 1995-09-21 Mallinckrodt Medical, Inc. Stabilisation de peptides et de proteines dans le but d'une utilisation radiopharmaceutique
EP0988861A1 (fr) * 1998-08-17 2000-03-29 Pfizer Products Inc. Composition de protéines stabilisée
EP1136068A2 (fr) * 2000-03-21 2001-09-26 Jcr Pharmaceuticals Co., Ltd. Poudre de peptide à activité physiologique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHANG M Z ET AL: "A NEW STRATEGY FOR ENHANCING THE STABILITY OF LYOPHILIZED PROTEIN: THE EFFECT OF THE RECONSTITUTION MEDIUM ON KERATINOCYTE GROWTH FACTOR", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 12, no. 10, 1995, pages 1447 - 1452, XP009007833, ISSN: 0724-8741 *

Also Published As

Publication number Publication date
OA12935A (en) 2006-10-13
AU2003271642A1 (en) 2004-04-19
AP2005003253A0 (en) 2005-03-31
WO2004028259A2 (fr) 2004-04-08
AU2003271642A8 (en) 2004-04-19
ITBA20020032A1 (it) 2004-03-25

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