WO2004026857A3 - Methods of purifying cannabinoids from plant material - Google Patents

Methods of purifying cannabinoids from plant material Download PDF

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Publication number
WO2004026857A3
WO2004026857A3 PCT/GB2003/004078 GB0304078W WO2004026857A3 WO 2004026857 A3 WO2004026857 A3 WO 2004026857A3 GB 0304078 W GB0304078 W GB 0304078W WO 2004026857 A3 WO2004026857 A3 WO 2004026857A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
plant material
cannabinoids
purifying cannabinoids
substantially pure
Prior art date
Application number
PCT/GB2003/004078
Other languages
French (fr)
Other versions
WO2004026857A2 (en
Inventor
Ian Flockhart
Gary William Wheatley
Su Dring
Lesley Archer
Original Assignee
Gw Pharma Ltd
Ian Flockhart
Gary William Wheatley
Su Dring
Lesley Archer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gw Pharma Ltd, Ian Flockhart, Gary William Wheatley, Su Dring, Lesley Archer filed Critical Gw Pharma Ltd
Priority to DE60330363T priority Critical patent/DE60330363D1/en
Priority to AT03750947T priority patent/ATE450521T1/en
Priority to EP03750947A priority patent/EP1542984B1/en
Priority to AU2003269167A priority patent/AU2003269167A1/en
Priority to CA2499492A priority patent/CA2499492C/en
Priority to US10/528,951 priority patent/US7700368B2/en
Publication of WO2004026857A2 publication Critical patent/WO2004026857A2/en
Publication of WO2004026857A3 publication Critical patent/WO2004026857A3/en
Priority to US12/714,907 priority patent/US8846409B2/en
Priority to US14/471,113 priority patent/US20150203434A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to methods of preparing cannabinoids in substantially pure form starting from plant material. Also described are substantially pure preparations of various cannabinoids and cannabinoid acids, and also extracts enriched in cannabinoids and cannabinoid acids.
PCT/GB2003/004078 2002-09-23 2003-09-23 Methods of purifying cannabinoids from plant material WO2004026857A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE60330363T DE60330363D1 (en) 2002-09-23 2003-09-23 METHODS FOR CLEANING CANNABINOIDS FROM PLANT MATERIAL
AT03750947T ATE450521T1 (en) 2002-09-23 2003-09-23 METHODS FOR PURIFYING CANNABINOIDS FROM PLANT MATERIAL
EP03750947A EP1542984B1 (en) 2002-09-23 2003-09-23 Methods of purifying cannabinoids from plant material
AU2003269167A AU2003269167A1 (en) 2002-09-23 2003-09-23 Methods of purifying cannabinoids from plant material
CA2499492A CA2499492C (en) 2002-09-23 2003-09-23 Methods of preparing cannabinoids from plant material
US10/528,951 US7700368B2 (en) 2002-09-23 2003-09-23 Methods of purifying cannabinoids from plant material
US12/714,907 US8846409B2 (en) 2002-09-23 2010-03-01 Methods of preparing cannabinoids from plant material
US14/471,113 US20150203434A1 (en) 2002-09-23 2014-08-28 Methods of preparing cannabinoids from plant material

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0222077.0A GB0222077D0 (en) 2002-09-23 2002-09-23 Methods of preparing cannabinoids from plant material
GB0222077.0 2002-09-23

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10528951 A-371-Of-International 2003-09-23
US10/528,951 A-371-Of-International US7700368B2 (en) 2002-09-23 2003-09-23 Methods of purifying cannabinoids from plant material
US12/714,907 Continuation US8846409B2 (en) 2002-09-23 2010-03-01 Methods of preparing cannabinoids from plant material

Publications (2)

Publication Number Publication Date
WO2004026857A2 WO2004026857A2 (en) 2004-04-01
WO2004026857A3 true WO2004026857A3 (en) 2004-08-12

Family

ID=9944620

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004078 WO2004026857A2 (en) 2002-09-23 2003-09-23 Methods of purifying cannabinoids from plant material

Country Status (9)

Country Link
US (3) US7700368B2 (en)
EP (2) EP2161262A1 (en)
AT (1) ATE450521T1 (en)
AU (1) AU2003269167A1 (en)
CA (1) CA2499492C (en)
DE (1) DE60330363D1 (en)
ES (1) ES2337460T3 (en)
GB (2) GB0222077D0 (en)
WO (1) WO2004026857A2 (en)

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