WO2004020468A3 - Interferon beta-like molecules for treatment of cancer - Google Patents

Interferon beta-like molecules for treatment of cancer Download PDF

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Publication number
WO2004020468A3
WO2004020468A3 PCT/DK2003/000554 DK0300554W WO2004020468A3 WO 2004020468 A3 WO2004020468 A3 WO 2004020468A3 DK 0300554 W DK0300554 W DK 0300554W WO 2004020468 A3 WO2004020468 A3 WO 2004020468A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
interferon
ifnb
mammal
life
Prior art date
Application number
PCT/DK2003/000554
Other languages
French (fr)
Other versions
WO2004020468A2 (en
Inventor
Poul Soerensen
Original Assignee
Maxygen Aps
Poul Soerensen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Aps, Poul Soerensen filed Critical Maxygen Aps
Priority to AU2003254641A priority Critical patent/AU2003254641A1/en
Publication of WO2004020468A2 publication Critical patent/WO2004020468A2/en
Publication of WO2004020468A3 publication Critical patent/WO2004020468A3/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to interferon β (IFNB) polypeptides with an increased half-life in the treatment of various cancers, in particular solid tumors. More particularly, the present invention is directed to a method of treating a mammal, in particular a human being, having a cancer, wherein said cancer has malignant cells carrying interferon type 1 deletions, by administering to said mammal a therapeutically effective dose of an IFNB polypeptide with increased functional in vivo half-life as compared to interferon β 1a. The present invention is also directed to a method of treating a mammal, in particular a human being, having cancer, comprising administering to said mammal a therapeutically effective dose of an interferon beta (IFNB) polypeptide with increased functional in vivo half-life as compared to interferon β 1a in combination with a chemotherapeutic agent. IFNB polypeptides with increased functional in vivo half-life are typically obtained through PEGylation of the IFNB polypeptide.
PCT/DK2003/000554 2002-08-28 2003-08-25 Interferon beta-like molecules for treatment of cancer WO2004020468A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003254641A AU2003254641A1 (en) 2002-08-28 2003-08-25 Interferon beta-like molecules for treatment of cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40718802P 2002-08-28 2002-08-28
US60/407,188 2002-08-28

Publications (2)

Publication Number Publication Date
WO2004020468A2 WO2004020468A2 (en) 2004-03-11
WO2004020468A3 true WO2004020468A3 (en) 2004-06-10

Family

ID=31978437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000554 WO2004020468A2 (en) 2002-08-28 2003-08-25 Interferon beta-like molecules for treatment of cancer

Country Status (2)

Country Link
AU (1) AU2003254641A1 (en)
WO (1) WO2004020468A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887674B1 (en) 1998-04-13 2005-05-03 California Institute Of Technology Artery- and vein-specific proteins and uses therefor
KR101238517B1 (en) 2002-12-26 2013-02-28 마운틴 뷰 파마슈티컬즈, 인크. Polymer conjugates of interferon-beta with enhanced biological potency
AU2004220525B2 (en) 2003-03-12 2011-03-31 Vasgene Therapeutics, Inc. Nucleic acid compounds for inhibiting angiogenesis and tumor growth
US7381410B2 (en) 2003-03-12 2008-06-03 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
KR20070034465A (en) 2004-03-12 2007-03-28 바스진 테라퓨틱스, 인크. Polypeptide Compounds for Inhibiting Angiogenesis and Tumor Growth
EP2287194B1 (en) 2004-03-12 2016-10-26 Vasgene Therapeutics, Inc. Antibodies binding to EphB4 for inhibiting angiogenesis and tumor growth
EP1799713B1 (en) * 2004-09-23 2014-11-05 VasGene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
US20120082647A1 (en) * 2010-10-01 2012-04-05 Baker Darren P Interferon-beta for use as monotherapy or in combination with other cancer therapies
MY168902A (en) 2011-10-01 2018-12-04 Glytech Inc Glycosylated polypeptide and pharmaceutical composition containing same
DK2982686T3 (en) * 2013-03-29 2018-10-08 Glytech Inc POLYPEPTIDE WITH SIALYLED SUGAR CHAIN CONNECTED
CN107773753B (en) * 2016-12-05 2020-12-22 四川好医生攀西药业有限责任公司 Medicine containing periplaneta americana and bleomycin and application thereof
WO2021221470A1 (en) * 2020-04-29 2021-11-04 (주) 제노팜 Recombinant protein having fused interferon-beta mutein and antibody, and pharmaceutical composition comprising same
CN115989239A (en) * 2020-04-29 2023-04-18 瑷备恩有限公司 Human interferon beta variants with double mutations and methods for improving the stability of human interferon beta variants

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271095A (en) * 1991-05-30 1993-10-19 Chugai Pharmaceut Co Ltd Anticancer agent
WO1998048018A1 (en) * 1997-04-23 1998-10-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Recombinant human beta interferon with enhanced solubility
WO1999003887A1 (en) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
WO1999055377A2 (en) * 1998-04-28 1999-11-04 Applied Research Systems Ars Holding N.V. Polyol-ifn-beta conjugates
JP2000109434A (en) * 1998-08-06 2000-04-18 Toray Ind Inc Inhibition of cell growth and cell growth inhibitor
WO2000023114A2 (en) * 1998-10-16 2000-04-27 Biogen, Inc. Polymer conjugates of interferon beta- 1a and their uses
WO2000023472A2 (en) * 1998-10-16 2000-04-27 Biogen, Inc. Interferon-beta fusion proteins and uses
WO2000068387A2 (en) * 1999-05-12 2000-11-16 Xencor, Inc. Nucleic acids and proteins with interferon-beta activity
WO2001015736A2 (en) * 1999-08-27 2001-03-08 Maxygen Aps Interferon-beta conjugates
WO2002036628A2 (en) * 2000-11-02 2002-05-10 Maxygen Aps New multimeric interferon beta polypeptides
WO2002055532A2 (en) * 2001-01-11 2002-07-18 Maxygen Aps Variant growth hormone molecules conjugated with macromolecular compounds
WO2002072019A2 (en) * 2001-03-13 2002-09-19 Vical Incorporated Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases
WO2002074806A2 (en) * 2001-02-27 2002-09-26 Maxygen Aps New interferon beta-like molecules
WO2003002152A2 (en) * 2001-06-29 2003-01-09 Maxygen Aps Stabilized formulations of interferons with sulfoalkyl ether cyclodextrins

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271095A (en) * 1991-05-30 1993-10-19 Chugai Pharmaceut Co Ltd Anticancer agent
WO1998048018A1 (en) * 1997-04-23 1998-10-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Recombinant human beta interferon with enhanced solubility
WO1999003887A1 (en) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
WO1999055377A2 (en) * 1998-04-28 1999-11-04 Applied Research Systems Ars Holding N.V. Polyol-ifn-beta conjugates
JP2000109434A (en) * 1998-08-06 2000-04-18 Toray Ind Inc Inhibition of cell growth and cell growth inhibitor
WO2000023472A2 (en) * 1998-10-16 2000-04-27 Biogen, Inc. Interferon-beta fusion proteins and uses
WO2000023114A2 (en) * 1998-10-16 2000-04-27 Biogen, Inc. Polymer conjugates of interferon beta- 1a and their uses
WO2000068387A2 (en) * 1999-05-12 2000-11-16 Xencor, Inc. Nucleic acids and proteins with interferon-beta activity
WO2001015736A2 (en) * 1999-08-27 2001-03-08 Maxygen Aps Interferon-beta conjugates
WO2002036628A2 (en) * 2000-11-02 2002-05-10 Maxygen Aps New multimeric interferon beta polypeptides
WO2002055532A2 (en) * 2001-01-11 2002-07-18 Maxygen Aps Variant growth hormone molecules conjugated with macromolecular compounds
WO2002074806A2 (en) * 2001-02-27 2002-09-26 Maxygen Aps New interferon beta-like molecules
WO2002072019A2 (en) * 2001-03-13 2002-09-19 Vical Incorporated Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases
WO2003002152A2 (en) * 2001-06-29 2003-01-09 Maxygen Aps Stabilized formulations of interferons with sulfoalkyl ether cyclodextrins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FRANCESCO RECCHIA ET AL: "Advanced Carcinoma of the Pancreas", AMERICAN JOURNAL OF CLINICAL ONCOLOGY, vol. 21, no. 3, 1998, pages 275 - 278, XP002263696 *
LAURA RUNKEL ET AL: "Structural and Functional Differences Between Glycosylated and Non-glycosylated Forms of Human Interferon-Beta (IFN-Beta)", PHARMACEUTICAL RESEARCH, vol. 15, no. 4, 1998, pages 641 - 649, XP002271902 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 046 (C - 1157) 25 January 1994 (1994-01-25) *
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 07 29 September 2000 (2000-09-29) *

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AU2003254641A8 (en) 2004-03-19
AU2003254641A1 (en) 2004-03-19

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