WO2004018703A3 - Synthase par recombinaison de la chalcomycine et des polycetides et genes les modifiant - Google Patents

Synthase par recombinaison de la chalcomycine et des polycetides et genes les modifiant Download PDF

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Publication number
WO2004018703A3
WO2004018703A3 PCT/US2003/026569 US0326569W WO2004018703A3 WO 2004018703 A3 WO2004018703 A3 WO 2004018703A3 US 0326569 W US0326569 W US 0326569W WO 2004018703 A3 WO2004018703 A3 WO 2004018703A3
Authority
WO
WIPO (PCT)
Prior art keywords
chalcomycin
recombinant
polyketide synthase
modifying genes
prepare
Prior art date
Application number
PCT/US2003/026569
Other languages
English (en)
Other versions
WO2004018703A2 (fr
Inventor
Leonard Katz
Ralph C Reid
Zhihao Hu
Andreas Schirmer
Shannon L Ward
Christopher Reeves
Original Assignee
Kosan Biosciences Inc
Leonard Katz
Ralph C Reid
Zhihao Hu
Andreas Schirmer
Shannon L Ward
Christopher Reeves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc, Leonard Katz, Ralph C Reid, Zhihao Hu, Andreas Schirmer, Shannon L Ward, Christopher Reeves filed Critical Kosan Biosciences Inc
Priority to AU2003260062A priority Critical patent/AU2003260062A1/en
Publication of WO2004018703A2 publication Critical patent/WO2004018703A2/fr
Publication of WO2004018703A3 publication Critical patent/WO2004018703A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Abstract

L'invention porte sur des domaines des synthases de la chalcomycine et des polycétides et sur les enzymes de modification et sur les polynucléotides les codant. L'invention porte également sur des procédés de préparation de la chalcomycine dans des quantités utiles d'un point de vue pharmaceutique et sur des procédés de préparation des analogues de la chalcomycine et autres polycétides utilisant les polynucléotides codant les domaines des synthases de la chalcomycine et des polycétides ou les enzymes les modifiant.
PCT/US2003/026569 2002-08-21 2003-08-21 Synthase par recombinaison de la chalcomycine et des polycetides et genes les modifiant WO2004018703A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003260062A AU2003260062A1 (en) 2002-08-21 2003-08-21 Recombinant chalcomycin polyketide synthase and modifying genes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US40519402P 2002-08-21 2002-08-21
US60/405,194 2002-08-21
US42099402P 2002-10-24 2002-10-24
US60/420,994 2002-10-24
US49396603P 2003-08-08 2003-08-08
US60/493,966 2003-08-08

Publications (2)

Publication Number Publication Date
WO2004018703A2 WO2004018703A2 (fr) 2004-03-04
WO2004018703A3 true WO2004018703A3 (fr) 2005-03-17

Family

ID=31950540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026569 WO2004018703A2 (fr) 2002-08-21 2003-08-21 Synthase par recombinaison de la chalcomycine et des polycetides et genes les modifiant

Country Status (2)

Country Link
AU (1) AU2003260062A1 (fr)
WO (1) WO2004018703A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065137A (en) * 1959-02-02 1962-11-20 Parke Davis & Co Chalcomycin and its fermentative production
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065137A (en) * 1959-02-02 1962-11-20 Parke Davis & Co Chalcomycin and its fermentative production
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REEVES ET AL.: "Production of Hybrid 16-Membered Macrolides by Expressing Combinations of Polyketide Synthase Genes in Engineered Streptomyces fradiae Hosts", CHEMISTRY & BIOLOGY, vol. 11, 2004, pages 1465 - 1472, XP004601880 *

Also Published As

Publication number Publication date
AU2003260062A8 (en) 2004-03-11
AU2003260062A1 (en) 2004-03-11
WO2004018703A2 (fr) 2004-03-04

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