WO2004018400A1 - Ethynylation process - Google Patents
Ethynylation process Download PDFInfo
- Publication number
- WO2004018400A1 WO2004018400A1 PCT/EP2003/008867 EP0308867W WO2004018400A1 WO 2004018400 A1 WO2004018400 A1 WO 2004018400A1 EP 0308867 W EP0308867 W EP 0308867W WO 2004018400 A1 WO2004018400 A1 WO 2004018400A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbonyl compound
- process according
- alkali metal
- methyl
- metal hydroxide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/94—Use of additives, e.g. for stabilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
- C07C33/042—Acyclic alcohols with carbon-to-carbon triple bonds with only one triple bond
Definitions
- the present invention relates to an ethynylation process. More particularly, the present invention relates to a process for the manufacture of acetylenically unsaturated alcohols (propargyl alcohol or 1-monosubstituted or 1,1-disubstituted derivatives thereof) in which process formaldehyde, an aldehyde other than formaldehyde, or a ketone, each of these being referred to hereinafter in general as a "carbonyl compound", is reacted with acetylene (ethyne) in the presence of ammonia and an alkali metal hydroxide wherein the molar ratio of the alkali metal hydroxide to the carbonyl compound is less than 1 : 200.
- acetylenically unsaturated alcohols propargyl alcohol or 1-monosubstituted or 1,1-disubstituted derivatives thereof
- reaction products are of use as intermediates in the synthesis of many useful end products, inter alia in the field of vitamins and carotenoids.
- one such useful intermediate is dehydrolinalool, which itself can be converted via citral to ⁇ -ionone and isophytol, themselves being known starting materials for vitamin A and vitamin E, respectively.
- the present invention provides a process for the manufacture of an acetylenically unsaturated alcohol comprising reacting formaldehyde, an aldehyde or a ketone (a carbonyl compound) with acetylene in the presence of ammonia and an alkali metal hydroxide, characterized in that the molar ratio of the alkali metal hydroxide to the carbonyl compound is less than 1 : 200.
- the simplest carbonyl compound which can be reacted with acetylene in accordance with the process of the present invention is formaldehyde, HCHO, the product being propargyl alcohol, HC ⁇ CCH 2 OH.
- any other aldehyde or of the ketone which can be reacted with acetylene in accordance with the process of the present invention is not critical, and any aldehyde or ketone with which acetylene is known to react to form an acetylenically unsaturated alcohol may be used, i.e. according to the equation
- the unspecified moieties attached to the "central" carbon atom by the dotted lines being those featured in known aldehydes and ketones or in any other aldehydes and ketones which can be produced analogously to the known ones.
- the aldehyde, including formaldehyde, or ketone maybe one of those of formula "R -CO-R " as defined in German Offenlegungsschrift (DOS) 2 018 971, the contents of which are incorporated herein for reference purposes.
- the starting carbonyl compound is a ketone of the general formula
- each of R 1 and R 2 independently, signifies hydrogen, alkyl, alkenyl, cycloalkyl-alkyl, cycloalkyl- alkenyl, cycloalkenyl- alkyl or cycloalkenyl-alkenyl, each of the last four mentioned groups being optionally substituted on its cycloalkyl or cycloalkenyl ring, as appropriate, by one to three methyl or ethyl groups, the total number of carbon atoms, including those of the -CH 2 -CO-CH 2 - moiety, not exceeding 40.
- R and/or R suitably contains up to 22 carbon atoms and may be straight chain or branched, which also applies to the alkenyl group. Said alkenyl group, in addition, may feature up to 4 double bonds.
- alkenyl or cycloalkenyl-alkenyl group signified by R and/or R features a cycloalkyl or cycloalkenyl ring, as appropriate, which has from 5 to 12 ring members; the alkyl or alkenyl part of such group can contain from 1 to 8 carbon atoms and be straight chain or branched, and in the case of alkenyl as part of such group this can feature up to 4 double bonds.
- the cycloalkyl or cycloalkenyl ring part of such groups is either unsubstituted or is substituted by one, two or three methyl or ethyl groups, whereby in the case of di- or trisubstitution the substituents can be the same (methyl or ethyl) or different (a mixture of methyl and ethyl substituents).
- a particularly preferred optionally substituted cycloalkenyl group is the well known 2,6,6-trimethyl-l-cyclohexen- 1-yl group.
- the total number of carbon atoms, including any ring methyl or ethyl substituent(s), if appropriate, of either R 1 or R 2 is limited by that of the remaining R 2 or R 1 , respectively, to satisfy the criterion of the molecule R 1 -CH 2 -CO-CH 2 -R 2 as a whole containing a maximum of 40 carbon atoms.
- ketones 6-methyl-5-hepten-2-one is a particularly preferred ketone which can be reacted with acetylene by the process of the present invention; the product in this case is 3,7-dimethyl-6-octen-l-yn-3-ol (dehydrolinalool) .
- alkali metal hydroxide used as the basic catalyst in the process of the present invention there may be used sodium hydroxide or potassium hydroxide, of which the latter is preferably used.
- the ammonia used as the solvent in the process of the present invention is maintained in the liquid state by appropriate choice of temperature and pressure, whereby at the same time an adequate acetylene pressure must also be provided and sustained in the reaction vessel.
- the reaction temperature is conveniently in the range from about 0°C to about 40°C.
- the pressure is maintained at an appropriate value, depending on the reaction temperature, which is suitably from about 5 bar to about 20 bar (about 0.5 MPa to about 2 MPa).
- the ethynylation is preferably effected at temperatures from about room temperature (about 20°C) to about 35°C.
- the molar ratio of the acetylene to the formaldehyde, aldehyde or ketone (carbonyl compound), e.g. a ketone of the formula I, in the reaction mixture for carrying out the process of the present invention is generally from about 2 : 1 to about 6 : 1. Furthermore, the molar ratio of ammonia to carbonyl compound in said process is generally from about 8 : 1 to about 35 : 1, preferably from about 10 : 1 to about 30 : 1.
- Characteristic of the process of the present invention is the relatively extremely small amount of alkali metal hydroxide used as the basic catalyst, i.e. the molar ratio of alkali metal hydroxide to carbonyl compound being less than 1 : 200 (1 : >200).
- the ratio range within which the inventive process is effected is conveniently from about 1 : 500 to 1 : 200, preferably from about 1 : 300 to about 1 : 220.
- the process of the present invention can be carried out in a manner known per se for the ethynylation of carbonyl compounds.
- the desired amounts of aqueous alkali metal hydroxide solution, the carbonyl compound and acetylene are introduced into a reactor.
- the reactor is then sealed and inertized by repeatedly filling with ammonia and venting. Finally, a desired amount of ammonia is introduced into the reactor.
- Acetylene is then also added in the desired amount with stirring to start the reaction. During the reaction further acetylene may be added semi- continuously to maintain a constant ketone: acetylene molar ratio.
- the process in accordance with the present invention can be carried out continuously, e.g. by continuous addition of a mixture of acetylene and ammonia together with the carbonyl compound and aqueous alkali hydroxide solution into a reactor, e.g. a plug- flow reactor, and continuous withdrawal of the product.
- a reactor e.g. a plug- flow reactor
- the process of the present invention is preferably effected in a continuous manner.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Formation Of Insulating Films (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03792289A EP1532092B1 (en) | 2002-08-16 | 2003-08-09 | Ethinylation process |
AU2003255407A AU2003255407A1 (en) | 2002-08-16 | 2003-08-09 | Ethynylation process |
US10/524,762 US7638658B2 (en) | 2002-08-16 | 2003-08-09 | Ethynylation process |
JP2004530118A JP4780959B2 (en) | 2002-08-16 | 2003-08-09 | Ethynylation method |
DE60324564T DE60324564D1 (en) | 2002-08-16 | 2003-08-09 | ETHINYLIERUNGSVERFAHREN |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02018458 | 2002-08-16 | ||
EP02018458.6 | 2002-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004018400A1 true WO2004018400A1 (en) | 2004-03-04 |
Family
ID=31896835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/008867 WO2004018400A1 (en) | 2002-08-16 | 2003-08-09 | Ethynylation process |
Country Status (10)
Country | Link |
---|---|
US (1) | US7638658B2 (en) |
EP (1) | EP1532092B1 (en) |
JP (1) | JP4780959B2 (en) |
KR (1) | KR20050056986A (en) |
CN (1) | CN1286789C (en) |
AT (1) | ATE413370T1 (en) |
AU (1) | AU2003255407A1 (en) |
DE (1) | DE60324564D1 (en) |
RU (1) | RU2323201C2 (en) |
WO (1) | WO2004018400A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007039245A1 (en) * | 2005-09-29 | 2007-04-12 | Dsm Ip Assets B.V. | Cleavage of alkynediols |
WO2007121826A1 (en) * | 2006-04-25 | 2007-11-01 | Dsm Ip Assets B.V. | TRANSPORT OF ETHYNE IN FORM OF α-ALKYNOLS AS ETHYNE PRECURSORS |
WO2014140032A1 (en) | 2013-03-13 | 2014-09-18 | Dsm Ip Assets B. V. | Process for the preparation of 3,7-dimethylnonan-1-ol |
WO2016059151A1 (en) * | 2014-10-16 | 2016-04-21 | Dsm Ip Assets B.V. | Ethynylation of polyunsaturated aldehydes and ketones |
US9611200B2 (en) | 2012-12-18 | 2017-04-04 | Dsm Ip Assets B.V. | (6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14 trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101341111B (en) * | 2005-12-20 | 2012-08-15 | 帝斯曼知识产权资产管理有限公司 | Process for ubiquinone intermediates |
KR100915390B1 (en) * | 2008-05-02 | 2009-09-03 | 한국해양연구원 | Composition comprising novel acetylenic alcohol compound or the extract of reniochalina sp. for preventing and treating cancer |
CN102476978B (en) * | 2010-11-24 | 2015-04-08 | 杨朝辉 | Novel synthetic method preparing alkynol compound from acetylene |
CN103113188A (en) * | 2011-11-17 | 2013-05-22 | 河北百灵威超精细材料有限公司 | Novel low-cost synthesis method of alkynol compounds |
WO2014056851A2 (en) | 2012-10-08 | 2014-04-17 | Dsm Ip Assets B.V. | Flavor and fragrance formulation (i) |
CN104854072A (en) | 2012-12-18 | 2015-08-19 | 帝斯曼知识产权资产管理有限公司 | (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10-dimetylundeca-3,5,9-trien-2-one |
MY195032A (en) | 2012-12-18 | 2023-01-04 | Dsm Ip Assets Bv | (6R,10R)-6,10,14-Trimetylpentadecan-2-One Prepared From (R)-6,10,14-Trimetylpentadec-5-en-2-One |
EA027932B1 (en) * | 2013-01-23 | 2017-09-29 | ДСМ АйПи АССЕТС Б.В. | Process for the production of 2-alkyl-3-butyn-2-ols |
EA202090596A1 (en) | 2017-09-04 | 2020-06-26 | ДСМ АйПи АССЕТС Б.В. | 6-CHROMANOL DERIVATIVES AND THEIR SYNTHESIS |
CN108358749B (en) * | 2018-02-07 | 2021-06-22 | 重庆弛源化工有限公司 | Method for producing propargyl alcohol |
EP3640233A1 (en) | 2018-10-16 | 2020-04-22 | Basf Se | Ethers and esters of tertiary alkanols for use as aroma chemicals |
EP3640234A1 (en) | 2018-10-16 | 2020-04-22 | Basf Se | Ethers and esters of 1-substituted cycloalkanols for use as aroma chemicals |
CN110143849B (en) * | 2019-06-05 | 2020-01-10 | 山东新和成维生素有限公司 | Preparation method of alkynol |
CN113880691B (en) * | 2021-09-27 | 2023-09-01 | 四川众邦新材料股份有限公司 | Method for synthesizing trimethyl dodecanol |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3709946A (en) * | 1970-07-31 | 1973-01-09 | Air Prod & Chem | Preparation of acetylenic alcohols |
FR2236822A1 (en) * | 1973-07-09 | 1975-02-07 | Inst Orch Khim | Tertiary acetylenic alcohols prodn - by reacting ketones with acetylene in liquid ammonia in the presence of alkai catalysts |
EP1256560A2 (en) * | 2001-05-11 | 2002-11-13 | Basf Aktiengesellschaft | Process for the preparation of higher alpha,beta-unsaturated alcohols |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3283014A (en) * | 1966-11-01 | Acetylenic alcohols from ketones and acetylene using aqueous alkaline hy- droxide catalyst | ||
US3082260A (en) * | 1959-05-20 | 1963-03-19 | Air Reduction | Preparation of acetylenic alcohols |
US3383427A (en) * | 1962-12-17 | 1968-05-14 | Dow Chemical Co | Procedure for synthesis of propargyl alcohol |
DE19635703A1 (en) * | 1996-09-03 | 1998-03-05 | Basf Ag | Process for the preparation of alkynediols or mixtures of alkynediols with alkyne monools |
DE102004009311A1 (en) * | 2004-02-26 | 2005-09-08 | Basf Ag | Process for the preparation of a propargyl alcohol and an allyl alcohol |
-
2003
- 2003-08-09 RU RU2005107412/04A patent/RU2323201C2/en active
- 2003-08-09 EP EP03792289A patent/EP1532092B1/en not_active Expired - Lifetime
- 2003-08-09 CN CNB038189887A patent/CN1286789C/en not_active Expired - Lifetime
- 2003-08-09 US US10/524,762 patent/US7638658B2/en not_active Expired - Lifetime
- 2003-08-09 KR KR1020057002556A patent/KR20050056986A/en not_active Application Discontinuation
- 2003-08-09 WO PCT/EP2003/008867 patent/WO2004018400A1/en active Application Filing
- 2003-08-09 DE DE60324564T patent/DE60324564D1/en not_active Expired - Lifetime
- 2003-08-09 JP JP2004530118A patent/JP4780959B2/en not_active Expired - Lifetime
- 2003-08-09 AU AU2003255407A patent/AU2003255407A1/en not_active Abandoned
- 2003-08-09 AT AT03792289T patent/ATE413370T1/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3709946A (en) * | 1970-07-31 | 1973-01-09 | Air Prod & Chem | Preparation of acetylenic alcohols |
FR2236822A1 (en) * | 1973-07-09 | 1975-02-07 | Inst Orch Khim | Tertiary acetylenic alcohols prodn - by reacting ketones with acetylene in liquid ammonia in the presence of alkai catalysts |
EP1256560A2 (en) * | 2001-05-11 | 2002-11-13 | Basf Aktiengesellschaft | Process for the preparation of higher alpha,beta-unsaturated alcohols |
Non-Patent Citations (1)
Title |
---|
R.J. TEDESCHI: "Base-Catalyzed reaction of Acetylene and Vinylacetylenes with Carbonyl Compounds in Liquid Ammonia under Pressure", J. ORG. CHEM., vol. 28, 1963, pages 1740 - 1743, XP002264209 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007039245A1 (en) * | 2005-09-29 | 2007-04-12 | Dsm Ip Assets B.V. | Cleavage of alkynediols |
WO2007121826A1 (en) * | 2006-04-25 | 2007-11-01 | Dsm Ip Assets B.V. | TRANSPORT OF ETHYNE IN FORM OF α-ALKYNOLS AS ETHYNE PRECURSORS |
EP1852410A1 (en) * | 2006-04-25 | 2007-11-07 | DSM IP Assets B.V. | Transport of ethyne in form of alpha-alkynols as ethyne precursors |
EA014387B1 (en) * | 2006-04-25 | 2010-10-29 | ДСМ АйПи АССЕТС Б.В. | TRANSPORT OF ETHYNE IN FORM OF α-ALKYNOLS AS ETHYNE PRECURSORS |
US8003843B2 (en) | 2006-04-25 | 2011-08-23 | Dsm Ip Assets B.V. | Transport of ethyne in form of α-alkynols as ethyne precursors |
US9611200B2 (en) | 2012-12-18 | 2017-04-04 | Dsm Ip Assets B.V. | (6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14 trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one |
WO2014140032A1 (en) | 2013-03-13 | 2014-09-18 | Dsm Ip Assets B. V. | Process for the preparation of 3,7-dimethylnonan-1-ol |
WO2016059151A1 (en) * | 2014-10-16 | 2016-04-21 | Dsm Ip Assets B.V. | Ethynylation of polyunsaturated aldehydes and ketones |
Also Published As
Publication number | Publication date |
---|---|
JP2005538142A (en) | 2005-12-15 |
US20050240066A1 (en) | 2005-10-27 |
DE60324564D1 (en) | 2008-12-18 |
JP4780959B2 (en) | 2011-09-28 |
EP1532092A1 (en) | 2005-05-25 |
RU2005107412A (en) | 2006-01-27 |
RU2323201C2 (en) | 2008-04-27 |
AU2003255407A1 (en) | 2004-03-11 |
US7638658B2 (en) | 2009-12-29 |
ATE413370T1 (en) | 2008-11-15 |
EP1532092B1 (en) | 2008-11-05 |
KR20050056986A (en) | 2005-06-16 |
CN1286789C (en) | 2006-11-29 |
CN1675152A (en) | 2005-09-28 |
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