WO2004017912A3 - Methods for increasing the rate of heart muscle contraction - Google Patents

Methods for increasing the rate of heart muscle contraction Download PDF

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Publication number
WO2004017912A3
WO2004017912A3 PCT/US2003/026366 US0326366W WO2004017912A3 WO 2004017912 A3 WO2004017912 A3 WO 2004017912A3 US 0326366 W US0326366 W US 0326366W WO 2004017912 A3 WO2004017912 A3 WO 2004017912A3
Authority
WO
WIPO (PCT)
Prior art keywords
heart muscle
methods
increasing
rate
muscle contraction
Prior art date
Application number
PCT/US2003/026366
Other languages
French (fr)
Other versions
WO2004017912A2 (en
Inventor
Colleen Brophy
Padmini Komalavillas
Walter J Pipkin
John A Johnston
Tony L Creazzo
Jarrett Burch
Original Assignee
Univ Arizona State
Med College Georgia Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona State, Med College Georgia Res Inst filed Critical Univ Arizona State
Priority to AU2003269985A priority Critical patent/AU2003269985A1/en
Publication of WO2004017912A2 publication Critical patent/WO2004017912A2/en
Publication of WO2004017912A3 publication Critical patent/WO2004017912A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides methods for increasing the contractile rate in heart muscle and methods for treating of preventing various heart muscle disorders, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
PCT/US2003/026366 2002-08-22 2003-08-22 Methods for increasing the rate of heart muscle contraction WO2004017912A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003269985A AU2003269985A1 (en) 2002-08-22 2003-08-22 Methods for increasing the rate of heart muscle contraction

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40519902P 2002-08-22 2002-08-22
US60/405,199 2002-08-22
US44895303P 2003-02-21 2003-02-21
US60/448,953 2003-02-21

Publications (2)

Publication Number Publication Date
WO2004017912A2 WO2004017912A2 (en) 2004-03-04
WO2004017912A3 true WO2004017912A3 (en) 2004-12-09

Family

ID=31949888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026366 WO2004017912A2 (en) 2002-08-22 2003-08-22 Methods for increasing the rate of heart muscle contraction

Country Status (2)

Country Link
AU (1) AU2003269985A1 (en)
WO (1) WO2004017912A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004025300D1 (en) 2003-02-21 2010-03-11 Univ Arizona Use of HSP20 to promote wound healing and / or reduce scarring
WO2005037236A2 (en) 2003-10-17 2005-04-28 Arizona Board Of Regents Novel heat shock protein 20-related polypeptides and uses therefor
EP1912663A4 (en) * 2005-08-12 2010-01-06 Univ Cincinnati Methods of improving cardiac function and attenuating and/or preventing cardiac remodeling with hsp20

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLUHM W.F. ET AL: "Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes", AM. J. PHYSIOL., vol. 275, no. 44, 1998, pages H2243 - H2249, XP002981374 *
HEIN S. ET AL: "The role of the cytoskeleton in heart failure", CARDIOVASCULAR RESEARCH, vol. 45, 2000, pages 273 - 278, XP002981377 *
KNOWLTON A.A. ET AL: "Differential expression of heat shock proteins in normal and failing human hearts", J. MOL. CELL. CARDIOL., vol. 30, 1998, pages 811 - 818, XP002981375 *
MCDONALD K.S. ET AL: "It takes "heart" to win: What makes the heart powerful?", NEWS PHYSIOL. SCI., vol. 17, 2002, pages 185 - 190, XP002981376 *
NIWA M. ET AL: "Small molecular weight heat shock-related protein, HSP20, exhibits an anti-platelet activity by inhibiting receptor-mediated calcium influx", LIFE SCIENCES, vol. 66, no. 1, 2000, pages PL7 - PL12, XP002981373 *

Also Published As

Publication number Publication date
AU2003269985A8 (en) 2004-03-11
AU2003269985A1 (en) 2004-03-11
WO2004017912A2 (en) 2004-03-04

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