WO2004016729A3 - SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS - Google Patents

SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS Download PDF

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Publication number
WO2004016729A3
WO2004016729A3 PCT/US2003/025907 US0325907W WO2004016729A3 WO 2004016729 A3 WO2004016729 A3 WO 2004016729A3 US 0325907 W US0325907 W US 0325907W WO 2004016729 A3 WO2004016729 A3 WO 2004016729A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
reaction
control
chip
chips
Prior art date
Application number
PCT/US2003/025907
Other languages
French (fr)
Other versions
WO2004016729A2 (en
Inventor
Scott E Miller
Gennady Malin
Howard B Schreyer
Seth T Rodgers
Andrey J Zarur
Original Assignee
Bioprocessors Corp
Scott E Miller
Gennady Malin
Howard B Schreyer
Seth T Rodgers
Andrey J Zarur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/457,049 external-priority patent/US20040058437A1/en
Priority claimed from US10/457,015 external-priority patent/US20040058407A1/en
Application filed by Bioprocessors Corp, Scott E Miller, Gennady Malin, Howard B Schreyer, Seth T Rodgers, Andrey J Zarur filed Critical Bioprocessors Corp
Priority to AU2003265491A priority Critical patent/AU2003265491A1/en
Priority to US10/664,068 priority patent/US20050026134A1/en
Publication of WO2004016729A2 publication Critical patent/WO2004016729A2/en
Publication of WO2004016729A3 publication Critical patent/WO2004016729A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Abstract

The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
PCT/US2003/025907 2002-04-10 2003-08-19 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS WO2004016729A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003265491A AU2003265491A1 (en) 2002-08-19 2003-08-19 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS
US10/664,068 US20050026134A1 (en) 2002-04-10 2003-09-16 Systems and methods for control of pH and other reactor environment conditions

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US22356202A 2002-08-19 2002-08-19
US10/223,562 2002-08-19
US40927302P 2002-09-09 2002-09-09
US60/409,273 2002-09-09
US45693403A 2003-06-05 2003-06-05
US45704803A 2003-06-05 2003-06-05
US45613303A 2003-06-05 2003-06-05
US10/457,049 US20040058437A1 (en) 2001-04-10 2003-06-05 Materials and reactor systems having humidity and gas control
US10/457,015 US20040058407A1 (en) 2001-04-10 2003-06-05 Reactor systems having a light-interacting component
US10/457,015 2003-06-05
US10/456,133 2003-06-05
US10/457,049 2003-06-05
US10/457,048 2003-06-05
US10/456,934 2003-06-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/664,068 Continuation US20050026134A1 (en) 2002-04-10 2003-09-16 Systems and methods for control of pH and other reactor environment conditions

Publications (2)

Publication Number Publication Date
WO2004016729A2 WO2004016729A2 (en) 2004-02-26
WO2004016729A3 true WO2004016729A3 (en) 2005-06-30

Family

ID=31892403

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/025943 WO2004069983A2 (en) 2001-04-10 2003-08-19 Microreactor architecture and methods
PCT/US2003/025956 WO2004016727A1 (en) 2001-04-10 2003-08-19 Determination and/or control of reactor environmental conditions
PCT/US2003/025907 WO2004016729A2 (en) 2002-04-10 2003-08-19 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2003/025943 WO2004069983A2 (en) 2001-04-10 2003-08-19 Microreactor architecture and methods
PCT/US2003/025956 WO2004016727A1 (en) 2001-04-10 2003-08-19 Determination and/or control of reactor environmental conditions

Country Status (5)

Country Link
EP (2) EP1530626A1 (en)
JP (2) JP2006521786A (en)
AU (3) AU2003265491A1 (en)
CA (2) CA2496017A1 (en)
WO (3) WO2004069983A2 (en)

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US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
GB0210809D0 (en) * 2002-05-11 2002-06-19 Univ Durham Reactor
JP4664646B2 (en) * 2004-10-20 2011-04-06 一般社団法人オンチップ・セロミクス・コンソーシアム Cell culture microchamber and cell structure construction method
US20080233607A1 (en) * 2004-11-11 2008-09-25 Hanry Yu Cell Culture Device
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
AU2005311631B2 (en) 2004-12-03 2012-06-07 Cytonome/St, Llc Unitary cartridge for particle processing
DE102005004075B4 (en) * 2005-01-28 2008-04-03 Umicore Ag & Co. Kg Ceramic microreactor
EP2537657A3 (en) 2005-08-09 2016-05-04 The University of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
DE102006030068A1 (en) 2006-06-28 2008-01-03 M2P-Labs Gmbh Apparatus and method for the supply and removal of fluids in shaken microreactors arrays
JP2010510476A (en) 2006-07-19 2010-04-02 バイオナノマトリックス、インク． Nanonozzle device array: fabrication and use in polymer analysis
US7811359B2 (en) 2007-01-18 2010-10-12 General Electric Company Composite membrane for separation of carbon dioxide
JP2008194029A (en) * 2007-01-19 2008-08-28 Tosoh Corp Cell fusion apparatus and cell fusion method using the same
AU2008232616B2 (en) * 2007-03-28 2014-08-07 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
JP4963437B2 (en) * 2007-03-30 2012-06-27 京セラ株式会社 Flow path body, wiring board, flow path forming wiring board, flow path forming method, flow path body manufacturing method, and flow path body kit
EP2203548A4 (en) 2007-10-11 2014-01-15 Agency Science Tech & Res Forming cell structure with transient linker in cage
EP2285950A1 (en) * 2008-06-13 2011-02-23 FOSS Analytical A/S Process control of biotechnological processes
US8628919B2 (en) 2008-06-30 2014-01-14 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
JP5846703B2 (en) 2008-11-18 2016-01-20 バイオナノ ジェノミックス、インク． Polynucleotide mapping and sequencing
DE102014214077A1 (en) * 2014-07-18 2016-01-21 Hamilton Bonaduz Ag Laboratory containers, in particular cell culture containers, with a gas compensation line extending into the container volume
JP6292323B2 (en) * 2015-01-26 2018-03-14 宇部興産株式会社 Long-term cell culture using a polyimide porous membrane, and cryopreservation method of cells using a polyimide porous membrane
NL2020612B1 (en) 2017-12-22 2019-07-02 Illumina Inc Light detection devices with protective liner and methods of manufacturing same
CN109799012B (en) * 2019-01-23 2021-01-22 河南工程学院 Cellulose-based sandwich-like structure pressure sensor and preparation method thereof
WO2023057602A1 (en) * 2021-10-08 2023-04-13 Philip Morris Products S.A. Detection of bioactive agents in a surrounding medium

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Also Published As

Publication number Publication date
WO2004016727B1 (en) 2004-07-08
EP1567637A2 (en) 2005-08-31
WO2004016727A1 (en) 2004-02-26
EP1530626A1 (en) 2005-05-18
WO2004069983A2 (en) 2004-08-19
AU2003265491A1 (en) 2004-03-03
JP2005536233A (en) 2005-12-02
CA2495617A1 (en) 2004-02-26
WO2004016727A9 (en) 2004-05-27
AU2003265491A8 (en) 2004-03-03
JP2006521786A (en) 2006-09-28
WO2004069983A9 (en) 2005-02-03
WO2004069983A3 (en) 2005-07-14
AU2003272223A1 (en) 2004-03-03
AU2003303303A1 (en) 2004-08-30
CA2496017A1 (en) 2004-08-19
WO2004016729A2 (en) 2004-02-26

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