WO2004016223A3 - Assaying compounds or agents for microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase activity - Google Patents

Assaying compounds or agents for microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase activity Download PDF

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Publication number
WO2004016223A3
WO2004016223A3 PCT/US2003/025766 US0325766W WO2004016223A3 WO 2004016223 A3 WO2004016223 A3 WO 2004016223A3 US 0325766 W US0325766 W US 0325766W WO 2004016223 A3 WO2004016223 A3 WO 2004016223A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostaglandin
synthase
agents
hematopoietic
microsomal
Prior art date
Application number
PCT/US2003/025766
Other languages
French (fr)
Other versions
WO2004016223A2 (en
Inventor
Zhuyin Li
Junjie Xiong
Y Henry Di Ma
Jeffrey S Sabol
Original Assignee
Aventis Pharma Inc
Zhuyin Li
Junjie Xiong
Jeffrey S Sabol
Hu Linghong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0229244.9A external-priority patent/GB0229244D0/en
Application filed by Aventis Pharma Inc, Zhuyin Li, Junjie Xiong, Jeffrey S Sabol, Hu Linghong filed Critical Aventis Pharma Inc
Priority to EP03788590A priority Critical patent/EP1543327A2/en
Priority to IL16678203A priority patent/IL166782A0/en
Priority to CA002495391A priority patent/CA2495391A1/en
Priority to AU2003258278A priority patent/AU2003258278A1/en
Priority to JP2004529521A priority patent/JP2006511789A/en
Publication of WO2004016223A2 publication Critical patent/WO2004016223A2/en
Publication of WO2004016223A3 publication Critical patent/WO2004016223A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Provided herein is a novel and useful method for evaluating the ability of compounds or agents to decrease the activity of microsomal prostaglandin E synthase or hematopoietic prostaglandin D synthase to produce their respective prostaglandin products.
PCT/US2003/025766 2002-08-16 2003-08-15 Assaying compounds or agents for microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase activity WO2004016223A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03788590A EP1543327A2 (en) 2002-08-16 2003-08-15 Method for assaying compounds or agents for ability to decrease the activity of microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase
IL16678203A IL166782A0 (en) 2002-08-16 2003-08-15 Method for assaying compounds or agents for ability to decrease the activity of microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase
CA002495391A CA2495391A1 (en) 2002-08-16 2003-08-15 Assaying compounds or agents for microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase activity
AU2003258278A AU2003258278A1 (en) 2002-08-16 2003-08-15 Assaying compounds or agents for microsomal prostaglandin E synthase or hematopoietic prostaglandin D synthase activity
JP2004529521A JP2006511789A (en) 2002-08-16 2003-08-15 Methods for assaying compounds or agents for the ability to reduce the activity of microsomal prostaglandin E synthase or hematopoietic prostaglandin D synthase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40400802P 2002-08-16 2002-08-16
US60/404,008 2002-08-16
GBGB0229244.9A GB0229244D0 (en) 2002-08-16 2002-12-16 Method for assaying compounds for inhibition of the activity of prostaglandin synthase
GB0229244.9 2002-12-16

Publications (2)

Publication Number Publication Date
WO2004016223A2 WO2004016223A2 (en) 2004-02-26
WO2004016223A3 true WO2004016223A3 (en) 2004-10-21

Family

ID=31889687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025766 WO2004016223A2 (en) 2002-08-16 2003-08-15 Assaying compounds or agents for microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase activity

Country Status (9)

Country Link
EP (1) EP1543327A2 (en)
JP (1) JP2006511789A (en)
KR (1) KR20050035885A (en)
CN (1) CN1675543A (en)
AU (1) AU2003258278A1 (en)
CA (1) CA2495391A1 (en)
IL (1) IL166782A0 (en)
RU (1) RU2005107329A (en)
WO (1) WO2004016223A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101178144B1 (en) * 2004-06-30 2012-08-29 아벤티스 파마슈티칼스 인크. Methods involving microsomal prostaglandin e2 synthase
WO2006123677A1 (en) * 2005-05-17 2006-11-23 Taiho Pharmaceutical Co., Ltd. Method for diagnosis of severity and prediction of recurrence in eosinophilic inflammatory disease
MY154895A (en) 2007-03-30 2015-08-14 Sanofi Aventis Pyrimidine hydrazide compounds as pgds inhibitors
KR100913148B1 (en) * 2007-04-10 2009-08-19 이금필 Magnetic force-based bio sensor comprising magnetic particles
CA2722420A1 (en) * 2008-05-13 2009-11-19 Cayman Chemical Company, Incorporated Methods for assaying compounds or agents for ability to displace potent ligands of hematopoietic prostaglandin d synthase
TWI508960B (en) 2009-10-08 2015-11-21 Sanofi Aventis Phenyloxadiazole derivatives as pgds inhibitors
CN105254655B (en) * 2015-11-20 2017-03-22 江汉大学 Fluorescent amino acid based on BODIPY as well as synthetic method and application thereof
CN109781990A (en) * 2018-12-25 2019-05-21 无锡市人民医院 A kind of β-trace protein detection kit and preparation method
CN113174424B (en) * 2021-03-15 2023-05-26 合肥康诺生物制药股份有限公司 Method for detecting enzyme activity in aerobic enzymatic reaction and method for judging fermentation end point of recombinant escherichia coli

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAKOBSSON ET AL.: "Identification of human protaglandin E synthase: A microsomal glutathione-dependent, inducible enzyme, constituting a potential novel druf target", PROC. NATL. ACAD. SCI., vol. 96, June 1999 (1999-06-01), pages 7220 - 7225, XP002132551 *
KANAOKA ET AL.: "Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase", EUR. J. BIOCHEM., vol. 267, 2000, pages 3315 - 3322, XP002990403 *

Also Published As

Publication number Publication date
CA2495391A1 (en) 2004-02-26
RU2005107329A (en) 2005-08-27
JP2006511789A (en) 2006-04-06
IL166782A0 (en) 2006-01-15
CN1675543A (en) 2005-09-28
KR20050035885A (en) 2005-04-19
AU2003258278A1 (en) 2004-03-03
WO2004016223A2 (en) 2004-02-26
EP1543327A2 (en) 2005-06-22

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