WO2004015098A2 - Molecule d'adhesion cellulaire epitheliale rhesus, nucleotides codant cette molecule et utilisations associees - Google Patents
Molecule d'adhesion cellulaire epitheliale rhesus, nucleotides codant cette molecule et utilisations associees Download PDFInfo
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- WO2004015098A2 WO2004015098A2 PCT/EP2003/008504 EP0308504W WO2004015098A2 WO 2004015098 A2 WO2004015098 A2 WO 2004015098A2 EP 0308504 W EP0308504 W EP 0308504W WO 2004015098 A2 WO2004015098 A2 WO 2004015098A2
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- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne une molécule d'adhésion cellulaire épithéliale de singe rhésus codant des ADN (rhEp-CAM) ayant été isolée, clonée et séquencée. Le gène codant Ep-CAM est généralement associé au développement de carcinomes humains dérivés de l'épithélium. L'invention concerne des compositions et des méthodes permettant de provoquer ou d'améliorer l'immunité par rapport au produit protéinique exprimé par l'antigène associé à la tumeur Ep-CAM, l'expression de Ep-CAM aberrante étant associée à un carcinome ou à son développement. L'invention concerne en particulier des constructions de vecteur adénoviral portant rhEp-CAM, et leur utilisation dans des vaccins et dans des compositions pharmaceutiques pour prévenir et pour traiter le cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003251679A AU2003251679A1 (en) | 2002-08-07 | 2003-07-31 | Rhesus epithelial cell adhesion molecule, nucleic acid encoding the same, and uses thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40169102P | 2002-08-07 | 2002-08-07 | |
| US60/401,691 | 2002-08-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004015098A2 true WO2004015098A2 (fr) | 2004-02-19 |
| WO2004015098A3 WO2004015098A3 (fr) | 2004-03-18 |
Family
ID=31715719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2003/008504 WO2004015098A2 (fr) | 2002-08-07 | 2003-07-31 | Molecule d'adhesion cellulaire epitheliale rhesus, nucleotides codant cette molecule et utilisations associees |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003251679A1 (fr) |
| WO (1) | WO2004015098A2 (fr) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5738867A (en) * | 1991-11-26 | 1998-04-14 | Jenner Technologies | Antitumor vaccines |
-
2003
- 2003-07-31 AU AU2003251679A patent/AU2003251679A1/en not_active Abandoned
- 2003-07-31 WO PCT/EP2003/008504 patent/WO2004015098A2/fr not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5738867A (en) * | 1991-11-26 | 1998-04-14 | Jenner Technologies | Antitumor vaccines |
Non-Patent Citations (4)
| Title |
|---|
| LI W ET AL: "HUMAN COLORECTAL CANCER (CRC) ANTIGEN CO17-1A/GA733 ENCODED BY ADENOVIRUS INHIBITS GROWTH OF ESTABLISHED CRC CELLS IN MICE" JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 159, no. 2, 15 July 1997 (1997-07-15), pages 763-769, XP002061096 ISSN: 0022-1767 * |
| STAIB LUDGER ET AL: "Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients" INTERNATIONAL JOURNAL OF CANCER, vol. 92, no. 1, 1 April 2001 (2001-04-01), pages 79-87, XP002267174 ISSN: 0020-7136 * |
| SZALA S ET AL: "MOLECULAR CLONING OF CDNA FOR THE CARCINOMA-ASSOCIATED ANTIGEN GA 733-2" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 87, no. 9, 1 May 1990 (1990-05-01), pages 3542-3546, XP000566331 ISSN: 0027-8424 * |
| ZALOUDIK JAN ET AL: "Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-1A/EpCAM/KSA/KS1-4 antigen in mice." CANCER GENE THERAPY. ENGLAND APR 2002, vol. 9, no. 4, April 2002 (2002-04), pages 382-389, XP001157329 ISSN: 0929-1903 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004015098A3 (fr) | 2004-03-18 |
| AU2003251679A8 (en) | 2004-02-25 |
| AU2003251679A1 (en) | 2004-02-25 |
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