WO2004005540A3 - Utilisations de substances qui se lient a ngal pour le diagnostic et le traitement de maladies cancereuses - Google Patents

Utilisations de substances qui se lient a ngal pour le diagnostic et le traitement de maladies cancereuses Download PDF

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Publication number
WO2004005540A3
WO2004005540A3 PCT/DE2003/001986 DE0301986W WO2004005540A3 WO 2004005540 A3 WO2004005540 A3 WO 2004005540A3 DE 0301986 W DE0301986 W DE 0301986W WO 2004005540 A3 WO2004005540 A3 WO 2004005540A3
Authority
WO
WIPO (PCT)
Prior art keywords
ngal
diagnosis
treatment
binding substances
cancer diseases
Prior art date
Application number
PCT/DE2003/001986
Other languages
German (de)
English (en)
Other versions
WO2004005540A2 (fr
Inventor
Gunda Herberth
Edgar Dahl
Katrin Sparbier
Anke Stein
Esmeralda Heiden
Irina Klamann
Stafan Taudien
Andreas Rump
Rosemarie Lichtner
Bernd Hinzmann
Andre Rosenthal
Thomas Specht
Christian Pilarsky
Original Assignee
Gunda Herberth
Edgar Dahl
Katrin Sparbier
Anke Stein
Esmeralda Heiden
Irina Klamann
Stafan Taudien
Andreas Rump
Rosemarie Lichtner
Bernd Hinzmann
Andre Rosenthal
Thomas Specht
Christian Pilarsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gunda Herberth, Edgar Dahl, Katrin Sparbier, Anke Stein, Esmeralda Heiden, Irina Klamann, Stafan Taudien, Andreas Rump, Rosemarie Lichtner, Bernd Hinzmann, Andre Rosenthal, Thomas Specht, Christian Pilarsky filed Critical Gunda Herberth
Priority to AU2003245858A priority Critical patent/AU2003245858A1/en
Publication of WO2004005540A2 publication Critical patent/WO2004005540A2/fr
Publication of WO2004005540A3 publication Critical patent/WO2004005540A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des utilisations de Ngal pour le diagnostic et le traitement de cancers ou pour le criblage de substances utilisées à cet effet.
PCT/DE2003/001986 2002-07-02 2003-06-12 Utilisations de substances qui se lient a ngal pour le diagnostic et le traitement de maladies cancereuses WO2004005540A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003245858A AU2003245858A1 (en) 2002-07-02 2003-06-12 Uses of ngal-binding substances in the diagnosis and treatment of cancer diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10230631.1 2002-07-02
DE10230631A DE10230631A1 (de) 2002-07-02 2002-07-02 Verwendungen von an Ngal bindenden Substanzen zur Diagnose und Behandlung von Krebserkrankungen

Publications (2)

Publication Number Publication Date
WO2004005540A2 WO2004005540A2 (fr) 2004-01-15
WO2004005540A3 true WO2004005540A3 (fr) 2004-09-16

Family

ID=29761726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/001986 WO2004005540A2 (fr) 2002-07-02 2003-06-12 Utilisations de substances qui se lient a ngal pour le diagnostic et le traitement de maladies cancereuses

Country Status (3)

Country Link
AU (1) AU2003245858A1 (fr)
DE (1) DE10230631A1 (fr)
WO (1) WO2004005540A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006086638A2 (fr) * 2005-02-10 2006-08-17 Board Of Regents, The University Of Texas System Ciblage d'un facteur pro-apoptotique secrete a des fins de carcinotherapie
WO2008030370A1 (fr) * 2006-09-05 2008-03-13 Beth Israel Deaconess Medical Center, Inc. Utilisation de la lipocaline 2 dans la régulation de la sensibilité à l'insuline
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
JP2011501673A (ja) * 2007-10-19 2011-01-13 アボット・ラボラトリーズ グリコシル化された哺乳動物ｎｇａｌ及びその使用
CA2742291A1 (fr) 2008-11-05 2010-05-14 Abbott Laboratories Isoformes proteiques de lipocaline associee a une gelatinase neutrophile (ngal) enrichies a partir d'urine et de cellules d'ovaire de hamster chinois recombinantes (cho), et compositions apparentees, anticorps et procedes d'enrichissement, d'analyse et d'utilisation
GB201016852D0 (en) * 2010-10-07 2010-11-17 Univ York Cell differentiation
CN109709340B (zh) * 2018-12-29 2022-02-11 江苏众红生物工程创药研究院有限公司 人中性粒细胞明胶酶相关脂质运载蛋白定量检测卡及其临床应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030907A1 (fr) * 1997-01-06 1998-07-16 Wisconsin Alumni Research Foundation Dosage de detection immunohistochimique pour la determination de l'etat de proliferation d'un cancer
WO1999053040A2 (fr) * 1998-04-09 1999-10-21 Metagen Gesellschaft Für Genomforschung Mbh Sequences d'acide nucleique humain provenant de tissu de tumeur ovarienne
WO2002024866A2 (fr) * 2000-09-21 2002-03-28 University Of Massachusetts Procede d'induction de l'apoptose dans des cellules lymphoides
WO2002071928A2 (fr) * 2001-03-14 2002-09-19 Millennium Pharmaceuticals, Inc. Molecules d'acide nucleique et proteines destinees a l'identification, l'evaluation, la prevention et la therapie du cancer des ovaires
WO2002102235A2 (fr) * 2001-06-18 2002-12-27 Eos Biotechnology Inc. Procedes de diagnostic du cancer ovarien, compositions et procedes de criblage de modulateurs du cancer ovarien

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627034A (en) * 1995-12-05 1997-05-06 Wisconsin Alumni Research Foundation Assay for carcinoma proliferative status by measuring NGAL expression level
EP1242598A2 (fr) * 1999-12-30 2002-09-25 Corixa Corporation Composes pour l'immunotherapie et le diagnostic du cancer du colon et procedes d'utilisation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030907A1 (fr) * 1997-01-06 1998-07-16 Wisconsin Alumni Research Foundation Dosage de detection immunohistochimique pour la determination de l'etat de proliferation d'un cancer
WO1999053040A2 (fr) * 1998-04-09 1999-10-21 Metagen Gesellschaft Für Genomforschung Mbh Sequences d'acide nucleique humain provenant de tissu de tumeur ovarienne
WO2002024866A2 (fr) * 2000-09-21 2002-03-28 University Of Massachusetts Procede d'induction de l'apoptose dans des cellules lymphoides
WO2002071928A2 (fr) * 2001-03-14 2002-09-19 Millennium Pharmaceuticals, Inc. Molecules d'acide nucleique et proteines destinees a l'identification, l'evaluation, la prevention et la therapie du cancer des ovaires
WO2002102235A2 (fr) * 2001-06-18 2002-12-27 Eos Biotechnology Inc. Procedes de diagnostic du cancer ovarien, compositions et procedes de criblage de modulateurs du cancer ovarien

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BARTSCH S ET AL: "CLONING AND EXPRESSION OF HUMAN NEUTROPHIL LIPOCALIN CDNA DERIVED FROM BONE MARROW AND OVARIAN CANCER CELLS", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 357, 1995, pages 255 - 259, XP002061582, ISSN: 0014-5793 *
COWLAND J B ET AL: "MOLECULAR CHARACTERIZATION AND PATTERN OF TISSUE EXPRESSION OF THE GENE FOR NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN FROM HUMANS", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 45, 1997, pages 17 - 23, XP002909708, ISSN: 0888-7543 *
DATABASE GENESEQ [online] EBI; 27 December 2002 (2002-12-27), MACK AND GISH: "Detecting an ovarian cancer-associated transcript in a cell from a patient, comprises contacting a biological sample from the patient with a polynucleotide that hybridizes to an ovarian cancer gene", XP002271024, Database accession no. ADB80594 *
DATABASE GENESEQ [online] EBI; 3 January 2002 (2002-01-03), BIRSE ET AL.: "Isolated nucleic acid molecules encoding novel ovarian polypeptides, useful in the prevention, treatment and diagnosis of cancer (e.g. ovariancancer), immune disorders, cardiovascular disorders and neurological diseases", XP002271022, Database accession no. ABP41113 *
DATABASE GENESQ [online] EBI; 19 September 2002 (2002-09-19), MONAHAN ET AL.: "Assessing whether a patient is afflicted with ovarian cancer, useful in assessing the stage or progression of the disease, comprises comparing the expression level of a cancer marker in a sample from a patient and from a non cancer patient", XP002271023, Database accession no. ABG96361 *
FRIEDL A ET AL: "NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN NORMAL AND NEOPLASTIC HUMAN TISSUES. CELL TYPE-SPECIFIC PATTERN OF EXPRESSION", THE HISTOCHEMICAL JOURNAL, LONDON, GB, vol. 31, 1999, pages 433 - 441, XP002909707 *
STOESZ S P ET AL: "HETEROGENEOUS EXPRESSION OF THE LIPOCALIN NGAL IN PRIMARY BREAST CANCERS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 79, 1998, pages 565 - 572, XP000979576, ISSN: 0020-7136 *

Also Published As

Publication number Publication date
WO2004005540A2 (fr) 2004-01-15
AU2003245858A1 (en) 2004-01-23
AU2003245858A8 (en) 2004-01-23
DE10230631A1 (de) 2004-01-22

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