WO2004004740A1 - Aqueous formulation comprising digestible saccharides to reduce the tendency to cardiovascular disease in a subject - Google Patents
Aqueous formulation comprising digestible saccharides to reduce the tendency to cardiovascular disease in a subject Download PDFInfo
- Publication number
- WO2004004740A1 WO2004004740A1 PCT/GB2003/002914 GB0302914W WO2004004740A1 WO 2004004740 A1 WO2004004740 A1 WO 2004004740A1 GB 0302914 W GB0302914 W GB 0302914W WO 2004004740 A1 WO2004004740 A1 WO 2004004740A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aqueous formulation
- digestible saccharides
- subject
- tendency
- enzyme
- Prior art date
Links
- 239000013011 aqueous formulation Substances 0.000 title claims abstract description 64
- 150000001720 carbohydrates Chemical class 0.000 title claims abstract description 55
- 208000024172 Cardiovascular disease Diseases 0.000 title claims abstract description 22
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 34
- 229930182830 galactose Natural products 0.000 claims abstract description 32
- 102000004190 Enzymes Human genes 0.000 claims description 35
- 108090000790 Enzymes Proteins 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 14
- 150000002500 ions Chemical class 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 11
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 10
- 239000011707 mineral Substances 0.000 claims description 10
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
- 239000011591 potassium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 229910001431 copper ion Inorganic materials 0.000 claims description 6
- 239000011572 manganese Substances 0.000 claims description 6
- 229910001437 manganese ion Inorganic materials 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 102000005840 alpha-Galactosidase Human genes 0.000 claims description 3
- 108010030291 alpha-Galactosidase Proteins 0.000 claims description 3
- 239000003125 aqueous solvent Substances 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 229940035034 maltodextrin Drugs 0.000 claims description 3
- 150000002772 monosaccharides Chemical class 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 239000008121 dextrose Substances 0.000 claims description 2
- 150000002016 disaccharides Chemical class 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920001542 oligosaccharide Polymers 0.000 claims description 2
- 150000002482 oligosaccharides Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 11
- 230000002526 effect on cardiovascular system Effects 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 7
- 235000010755 mineral Nutrition 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 229960003975 potassium Drugs 0.000 description 4
- 229910001414 potassium ion Inorganic materials 0.000 description 4
- 229910001415 sodium ion Inorganic materials 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 229960003624 creatine Drugs 0.000 description 3
- 239000006046 creatine Substances 0.000 description 3
- 235000015872 dietary supplement Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000207199 Citrus Species 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 240000001890 Ribes hudsonianum Species 0.000 description 2
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 2
- 235000001466 Ribes nigrum Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000014151 Stomatognathic disease Diseases 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 240000001717 Vaccinium macrocarpon Species 0.000 description 2
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 2
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 235000004634 cranberry Nutrition 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 208000018035 Dental disease Diseases 0.000 description 1
- 208000024720 Fabry Disease Diseases 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 244000148687 Glycosmis pentaphylla Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 244000093965 Triphasia trifolia Species 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 235000019263 trisodium citrate Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to an aqueous formulation for satisfying at least a part of the dietary carbohydrate requirements of a subject, said aqueous formulation comprising digestible saccharides such as galactose with beneficial effects on a tendency to cardiovascular disease, and to uses of digestible saccharides therapeutically.
- Cardiovascular disease including coronary events and stroke
- cardiovascular disease is a major worldwide concern which effects individuals of any age. It involves significant mortality and has associated widespread economic and clinical implications.
- Galactose is a naturally occurring hexose for which worldwide demand is negligible and reported uses scarce.
- Prior publications relating to galactose include:
- WO-A-01/28360 discloses high energy multi-saccharide food products containing galactose and creatine for use in sport or to combat hunger or fatigue;
- EP-A-0340491 discloses a foodstuff in which the saccharide component is primarily galactose
- WO-A-96/18313 discloses formulations for increasing creatine uptake comprising creatine, insulin and a simple carbohydrate such as galactose
- WO-A-98/06418 discloses dietary supplements comprising galactose for nutritional support and treating various disorders
- US-A-5843921 (Childrens Hospital of Los Angeles) discloses formulations for treatment of diabetes comprising less than 3g per unit of simple sugars including galactose;
- WO-A-96/08979 discloses sports beverages comprising trehalose and galactose
- WO-A-90/02494 discloses a sports drink comprising galactose originating from a desalinated and hydrolised whey concentrate
- EP-A-349712 discloses foodstuffs containing a tooth protecting amount of galactose in the form of lactose hydrosylate.
- EP-A-184121 discloses anti-caries additives for sucrose foodstuffs comprising galactose I.
- the present invention is based on the recognition that by exercising careful control of carbohydrate nutrition, it may be possible to reduce the tendency to cardiovascular disease.
- the present invention relates to an aqueous formulation which essentially satisfies the dietary carbohydrate requirements of a subject in a manner which reduces a tendency to cardiovascular disease.
- the present invention provides an aqueous formulation for satisfying at least a part of the dietary carbohydrate requirements of a subject, said aqueous formulation comprising: one or more digestible saccharides at a concentration sufficient to satisfy at least a part of the dietary carbohydrate requirements and water, optionally together with one or more sources of mineral ions selected from the group consisting of sodium, potassium, calcium, zinc, copper, manganese and magnesium ions, wherein at least one of said digestible saccharides is present at a concentration sufficient to reduce the tendency to cardiovascular (eg heart and stroke) disease in the subject.
- aqueous formulation comprising: one or more digestible saccharides at a concentration sufficient to satisfy at least a part of the dietary carbohydrate requirements and water, optionally together with one or more sources of mineral ions selected from the group consisting of sodium, potassium, calcium, zinc, copper, manganese and magnesium ions, wherein at least one of said digestible saccharides is present at a concentration sufficient to reduce the tendency to cardiovascular (eg heart and stroke)
- the one or more digestible saccharides may be present at a concentration sufficient to satisfy a major proportion of the dietary carbohydrate requirements (eg to substantially fully (preferably wholly) satisfy the dietary carbohydrate requirements) of the subject.
- the at least one of said digestible saccharides is present at a concentration sufficient to stabilise or activate an enzyme or enzyme system, said enzyme or enzyme system being capable of reducing the tendency to cardiovascular (eg heart and stroke) disease in the subject.
- said enzyme or enzyme system is capable either (1) of eliminating a factor associated with the tendency to cardiovascular (eg heart or stroke) disease or (2) of promoting a factor associated with reducing the tendency to cardiovascular (eg heart or stroke) disease.
- the one or more digestible saccharides may be selected from the group consisting of digestible monosaccharides, disaccharides, oligosaccharides and polysaccharides. These may be natural or synthetic digestible saccharides.
- the one or more digestible saccharides may be selected from the group consisting of galactose, glucose, sucrose, dextrose, fructose, lactose, maltodextrin, starch (soluble) and maltose.
- the one or more digestible saccharides includes a digestible monosaccharide, particularly preferably galactose.
- the one or more digestible saccharides are galactose and glucose, particularly preferably is galactose (ie alone).
- Galactose may be present in an amount sufficient to stabilise an enzyme or enzyme system, said enzyme or enzyme system being capable of reducing the tendency to cardiovascular (eg heart and stroke) disease in the subject.
- the enzyme is ⁇ - galactosidase A. Enzymes stabilised in this manner are more effective in promoting normal metabolism.
- the total concentration of carbohydrate is in the range 50 to 350mM (broadly corresponding to a carbohydrate concentration of 1-25% w/v depending on the chain length of any carbohydrate higher than a monomer eg 1-15% w/v for maltodextrin or soluble starch), preferably 50 to 310mM, particularly preferably 55 to 250mM, more preferably 60 to 175mM, especially preferably 70 to 160mM.
- galactose and glucose are present in a total amount sufficient to satisfy at least a part of the dietary carbohydrate requirements and the ratio of molar concentration of galactose to glucose is in the range 1 :1 to 1 :0.1, preferably 1 : 1 to 1 :0.15, particularly preferably 1 :1 to 1:0.2, more preferably 1 :1 to 1 :0.4.
- the concentration of galactose in the aqueous formulation is in the range 50 to 300mM, preferably 70 to 250mM, more preferably 80 to 200mM.
- the concentration of glucose in the aqueous formulation is in the range 10 to lOOmM, preferably 20 to 80mM, particularly preferably 40 to 60mM.
- the source of sodium ions in the aqueous formulation of the invention is typically a sodium salt. Any physiologically tolerable sodium salt will suffice. Examples include sodium lactate, sodium chloride, sodium citrate, trisodium citrate, sodium hydrogenphosphate, disodium phosphate and sodium bicarbonate.
- the counter ion eg chloride, bicarbonate, phosphate, hydrogenphosphate or citrate
- the concentration of sodium ions in the aqueous formulation is in the range 1 to lOOmM, preferably 5 to 85mM, particularly preferably 10 to 75mM, more preferably 15 to 45mM, yet more preferably 25 to 40mM.
- the sodium ions assist co-transport of galactose in the gut.
- a preferred embodiment of the aqueous formulation comprises one or more sources of mineral ions selected from the group consisting of sodium, potassium and magnesium ions.
- the source of a mineral ion is typically a salt such as a chloride, phosphate or citrate.
- the aqueous formulation comprises a source of potassium ions (eg a potassium salt such as potassium chloride or potassium hydrogenphosphate or potassium citrate).
- a source of potassium ions eg a potassium salt such as potassium chloride or potassium hydrogenphosphate or potassium citrate.
- concentration of potassium ions in the aqueous formulation is in the range 1 to 35mM, preferably 10 to 25mM, particularly preferably 15 to 20mM.
- the potassium ions are useful in the metabolism of carbohydrates.
- the aqueous formulation comprises a source of magnesium ions (eg a magnesium salt such as magnesium chloride).
- a source of magnesium ions eg a magnesium salt such as magnesium chloride.
- the concentration of magnesium ions in the aqueous formulation is in the range 1 to lOmM, preferably 2 to 8mM, particularly preferably 3 to 7mM, more preferably about 5mM.
- the aqueous formulation comprises a source of soluble fibre.
- the concentration of fibre in the aqueous formulation is in the range 1 to 10% w/v, preferably 2 to 8% w/v, particularly preferably 4 to 6% w/v, more preferably about 5% w/v.
- the aqueous formulation is adapted for oral administration.
- the aqueous formulation of the invention may be administered as a consumable (eg a foodstuff, drink or nutritional supplement) or as a medicament.
- the aqueous formulation is conveniently palatable and for this purpose may further comprise natural or synthetic flavourings such as fruit flavourings (eg blackcurrant, strawberry, apple, citrus, lemon, lime, orange or cranberry) or caffeine and sweeteners.
- the aqueous formulation of the invention may further comprise physiologically tolerable stabilisers, anti-oxidants (eg ascorbic acid) and preservatives (eg sodium benzoate or sorbic acid) as desired for the safety, palatability and acceptability of the aqueous formulation.
- Citric acid may be added to the aqueous formulation for partial or total replacement of any citrate ion and for buffering purposes (typically to maintain pH in the range 2 to 6).
- the concentration of citrate ion in the aqueous formulation may be in the range 5 to 30mM, preferably 10 to 25mM, particularly preferably 10 to 15mM.
- the concentration of chloride ion in the aqueous formulation may be in the range 20 to lOOmM, preferably 30 to 90mM, more preferably 40 to 85mM, especially preferably 50 to 80mM.
- the concentration of phosphate ion in the aqueous formulation may be in the range 10 to lOOmM, preferably 30 to 90mM, more preferably 40 to 85mM, especially preferably 45 to 80mM.
- the phosphate ions are useful in the metabolism of carbohydrates and may act as a buffer.
- the administration dosage generally depends on the dietary carbohydrate requirements of the subject and reflects the size and age of the subject. Generally it is advisable for the volume dose to be sufficient to provide the carbohydrate requirements of the subject and to be administered at appropriate intervals. Typically a dose of aqueous formulation is in the range 100 to 200ml.
- the aqueous formulation of the invention may be an aqueous solution, aqueous dispersion or aqueous suspension.
- the aqueous formulation is an aqueous solution.
- the aqueous formulation (eg solution) is a reconstituent aqueous formulation (eg solution).
- a reconstituent aqueous formulation of the invention may be reconstituted by the end user at the point of use from a composition comprising one or more digestible saccharides and optionally one or more sources of mineral ions by addition of a suitable volume of aqueous solvent (eg water).
- the present invention provides a composition formulable (eg dissolvable) in aqueous solvent (eg water) to form an aqueous formulation as hereinbefore defined, said composition comprising one or more digestible saccharides in an amount sufficient to satisfy at least a part of the dietary carbohydrate requirements of a subject, optionally together with one or more sources of mineral ions selected from the group consisting of sodium, potassium, calcium, zinc, copper, manganese and magnesium ions, wherein at least one of said digestible saccharides is present in an amount sufficient to reduce the tendency to cardiovascular (eg heart and stroke) disease in the subject.
- aqueous solvent eg water
- composition of the invention may be provided in any suitable solid or liquid form.
- the composition may be provided in solid form such as powdered (eg effervescent or non-effervescent powdered) or tablet form or in liquid form such as gel or liquid concentrate form.
- the present invention seeks to improve the treatment of cardiovascular disease using certain digestible saccharides.
- the present invention provides the use of one or more digestible saccharides (and optionally one or more sources of mineral ions selected from the group consisting of sodium, potassium, calcium, zinc, copper, manganese or magnesium ions) for the preparation of a medicament for reducing the tendency of a subject to cardiovascular disease, wherein at least one of the one or more digestible saccharides is present in the medicament in an amount sufficient to reduce the tendency to cardiovascular (eg heart and stroke) disease in the subject.
- one or more digestible saccharides and optionally one or more sources of mineral ions selected from the group consisting of sodium, potassium, calcium, zinc, copper, manganese or magnesium ions
- the medicament may be administered by any convenient route (eg orally or by injection).
- the medicament is administered orally. It may be in a solid or liquid form and may be administrable as a foodstuff (eg a bar), nutritional supplement or drink or as a tablet or powder.
- the one or more digestible saccharides may be present at a concentration sufficient to satisfy at least a part of the dietary carbohydrate requirements of the subject.
- the one or more digestible saccharides may be present at a concentration sufficient to satisfy a major proportion of the dietary carbohydrate requirements (eg to substantially fully (preferably wholly) satisfy the dietary carbohydrate requirements) of the subject.
- the at least one of said digestible saccharides is present at a concentration sufficient to stabilise or activate an enzyme or enzyme system, said enzyme or enzyme system being capable of reducing the tendency to cardiovascular (eg heart and stroke) disease in the subject.
- said enzyme or enzyme system is capable either (1) of eliminating a factor associated with the tendency to cardiovascular (eg heart or stroke) disease or (2) of promoting a factor associated with reducing the tendency to cardiovascular (eg heart or stroke) disease.
- the medicament is or comprises (A) an aqueous formulation or (B) a composition formulable (eg dissolvable in water) into an aqueous formulation as hereinbefore defined.
- A an aqueous formulation
- B a composition formulable (eg dissolvable in water) into an aqueous formulation as hereinbefore defined.
- the one or more digestible saccharides include galactose (preferably alone).
- the present invention provides a method for reducing the tendency of a subject to cardiovascular disease comprising the step of: administering an effective dose of an aqueous formulation, composition or medicament as hereinbefore defined to the subject.
- Example 1 Five reconstituent aqueous formulations A-E were prepared which had the following components and concentrations after reconstitution in water:
- a solid mixture of pre- weighed components was prepared such that the specified concentrations were obtained when a certain proportion was dissolved in a specified volume of water.
- the unit volume of water added to reconstitute the composition may be up to 1000ml. Typically 250ml would be appropriate and a single dose may be made up of one, two or three 250ml unit volumes administered at appropriate intervals.
- Each aqueous formulation may be flavoured to be palatable as desired using lemon, lime, blackcurrant, orange, citrus or cranberry.
- Examples C, D and E may be particularly useful in reducing the tendency to cardiovascular (eg heart or stroke) disease.
- Examples F, G, H, I & J correspond respectively to A, B, C, D & E of the fibre-free formulations specified in Example 1.
- Examples F, G, H, I & J correspond respectively to A, B, C, D & E in terms of their respective use (Examples ABD are equivalent to FGI and Examples CDE are equivalent to HIJ).
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003281195A AU2003281195A1 (en) | 2002-07-05 | 2003-07-07 | Aqueous formulation comprising digestible saccharides to reduce the tendency to cardiovascular disease in a subject |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39421002P | 2002-07-05 | 2002-07-05 | |
GB0215591.9 | 2002-07-05 | ||
US60/394,210 | 2002-07-05 | ||
GB0215591A GB0215591D0 (en) | 2002-07-05 | 2002-07-05 | Formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004004740A1 true WO2004004740A1 (en) | 2004-01-15 |
Family
ID=30117099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/002914 WO2004004740A1 (en) | 2002-07-05 | 2003-07-07 | Aqueous formulation comprising digestible saccharides to reduce the tendency to cardiovascular disease in a subject |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003281195A1 (en) |
WO (1) | WO2004004740A1 (en) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0342369A2 (en) * | 1988-05-14 | 1989-11-23 | Biodyn AG | Caries protection agent |
EP0349712A1 (en) * | 1988-04-11 | 1990-01-10 | Biodyn AG | Foodstuff or beverage |
EP0560284A1 (en) * | 1992-03-10 | 1993-09-15 | Godo Shusei Co., Ltd. | Prophylactic and remedial preparation for diseases attendant on hyperglycemia, and wholesome food |
US5780094A (en) * | 1994-02-16 | 1998-07-14 | Marathade, Ltd. | Sports drink |
EP0922459A1 (en) * | 1997-12-12 | 1999-06-16 | Ernst-Günter Prof. Dr. Dr. Afting | Pharmaceutical compositions comprising D-galactose and the use thereof |
US20020035072A1 (en) * | 1998-06-01 | 2002-03-21 | Mount Sinai School Of Medicine Of New York University. | Method for enhancing mutant enzyme activities in lysosomal storage disorders |
WO2003039556A1 (en) * | 2001-11-07 | 2003-05-15 | Ceretech Limited | Rehydrating formulation |
-
2003
- 2003-07-07 AU AU2003281195A patent/AU2003281195A1/en not_active Abandoned
- 2003-07-07 WO PCT/GB2003/002914 patent/WO2004004740A1/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349712A1 (en) * | 1988-04-11 | 1990-01-10 | Biodyn AG | Foodstuff or beverage |
EP0342369A2 (en) * | 1988-05-14 | 1989-11-23 | Biodyn AG | Caries protection agent |
EP0560284A1 (en) * | 1992-03-10 | 1993-09-15 | Godo Shusei Co., Ltd. | Prophylactic and remedial preparation for diseases attendant on hyperglycemia, and wholesome food |
US5780094A (en) * | 1994-02-16 | 1998-07-14 | Marathade, Ltd. | Sports drink |
EP0922459A1 (en) * | 1997-12-12 | 1999-06-16 | Ernst-Günter Prof. Dr. Dr. Afting | Pharmaceutical compositions comprising D-galactose and the use thereof |
US20020035072A1 (en) * | 1998-06-01 | 2002-03-21 | Mount Sinai School Of Medicine Of New York University. | Method for enhancing mutant enzyme activities in lysosomal storage disorders |
WO2003039556A1 (en) * | 2001-11-07 | 2003-05-15 | Ceretech Limited | Rehydrating formulation |
Non-Patent Citations (2)
Title |
---|
FRUSTACI ANDREA ET AL: "Improvement in cardiac function in the cardiac variant of Fabry's disease with galactose-infusion therapy", NEW ENGLAND JOURNAL OF MEDICINE, vol. 345, no. 1, 5 July 2001 (2001-07-05), pages 25 - 32, XP009019775, ISSN: 0028-4793 * |
OKUMIYA TOSHIKA ET AL: "Galactose stabilizes various missense mutants of alpha-galactosidase in Fabry disease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 214, no. 3, 1995, pages 1219 - 1224, XP002259663, ISSN: 0006-291X * |
Also Published As
Publication number | Publication date |
---|---|
AU2003281195A1 (en) | 2004-01-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5114723A (en) | Beverage compositions for human consumption | |
US8778410B2 (en) | Oral or enteral composition useful for recovery of physical functions | |
US9522161B2 (en) | Performance enhancing composition and method of delivering nutrients | |
US5032411A (en) | Beverage compositions for human consumption | |
EP0651615B1 (en) | Improved endurance and rehydration composition | |
EP0681434B1 (en) | Rehydration drink | |
US4582705A (en) | Composition for detoxification | |
JP2009062370A (en) | Solid composition for reducing tooth erosion | |
WO1993020718A1 (en) | Food composition which inhibits formation of intestinal putrefaction product | |
EP2802322B1 (en) | Combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine for use in treating diabetic ulcers | |
US20150366906A1 (en) | Alkaline drink | |
US20060172016A1 (en) | Muscle cramp reliever | |
US20020054949A1 (en) | Fiber formulation | |
US20060246200A1 (en) | Hydroxyapatite in aqueous solution for bone health | |
EP1555897B1 (en) | Ergogenic multivitamin-mineral energy supplement for the prevention of muscle fatigue | |
KR20060113339A (en) | Composition for improving constipation comprising sugar and sugar alcohols | |
KR100613618B1 (en) | Method for maintaining oxidative metabolism attendant upon exercise and food for sport | |
US20030134804A1 (en) | Rehydrating formulation | |
WO2004004740A1 (en) | Aqueous formulation comprising digestible saccharides to reduce the tendency to cardiovascular disease in a subject | |
EP1494686B1 (en) | Oral rehydration composition | |
US8840941B2 (en) | Method for infusing calcium phosphate in water, juices and water beverages | |
WO2004004741A1 (en) | Aqueous formulation comprising digestible saccharides with beneficial effects on a tendency to cardiovascular disease | |
Jones | Intraperitoneal amino acids: a therapy whose time has come? | |
WO2003039556A1 (en) | Rehydrating formulation | |
EP1441741A1 (en) | Rehydrating formulation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |