WO2004003493A3 - Methods and kits for determining energy expenditure in living organisms by metabolic water production - Google Patents

Methods and kits for determining energy expenditure in living organisms by metabolic water production Download PDF

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Publication number
WO2004003493A3
WO2004003493A3 PCT/US2003/020052 US0320052W WO2004003493A3 WO 2004003493 A3 WO2004003493 A3 WO 2004003493A3 US 0320052 W US0320052 W US 0320052W WO 2004003493 A3 WO2004003493 A3 WO 2004003493A3
Authority
WO
WIPO (PCT)
Prior art keywords
energy expenditure
methods
kits
water production
living organisms
Prior art date
Application number
PCT/US2003/020052
Other languages
French (fr)
Other versions
WO2004003493A2 (en
Inventor
Marc K Hellerstein
Original Assignee
Univ California
Marc K Hellerstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Marc K Hellerstein filed Critical Univ California
Priority to AU2003253702A priority Critical patent/AU2003253702A1/en
Publication of WO2004003493A2 publication Critical patent/WO2004003493A2/en
Publication of WO2004003493A3 publication Critical patent/WO2004003493A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the measurement of energy expenditure. More specifically, it relates to methods of using labeled water to measure metabolic water production and thereby measure energy expenditure in an individual or one or more cells, such as a cell culture.
PCT/US2003/020052 2002-06-26 2003-06-25 Methods and kits for determining energy expenditure in living organisms by metabolic water production WO2004003493A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003253702A AU2003253702A1 (en) 2002-06-26 2003-06-25 Methods and kits for determining energy expenditure in living organisms by metabolic water production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39207202P 2002-06-26 2002-06-26
US60/392,072 2002-06-26

Publications (2)

Publication Number Publication Date
WO2004003493A2 WO2004003493A2 (en) 2004-01-08
WO2004003493A3 true WO2004003493A3 (en) 2004-07-01

Family

ID=30000806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020052 WO2004003493A2 (en) 2002-06-26 2003-06-25 Methods and kits for determining energy expenditure in living organisms by metabolic water production

Country Status (2)

Country Link
AU (1) AU2003253702A1 (en)
WO (1) WO2004003493A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910403A (en) 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
ATE502578T1 (en) 2001-10-24 2011-04-15 Univ California MEASUREMENT OF PROTEIN SYNTHESIS RATES IN HUMANS AND IN EXPERIMENTAL SYSTEMS BY USING ISOTOPICALLY LABELED WATER
CA2494715C (en) 2002-07-30 2014-07-08 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates using mass spectrometry
SG149699A1 (en) 2002-09-13 2009-02-27 Univ California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
JP2014526685A (en) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア Metabolic flow measurement, imaging, and microscopy
CA2858368A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653090B1 (en) * 1999-11-05 2003-11-25 University Of Alberta Methods for measuring the metabolism of and screening for drugs in isolated hearts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653090B1 (en) * 1999-11-05 2003-11-25 University Of Alberta Methods for measuring the metabolism of and screening for drugs in isolated hearts

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BERTANI ET AL.: "Measurement of Total Body Water Through in vivo Dilution of Tracer Compounds", ANNALI DI CHIMICA (ROME), vol. 92, no. 1/2, January 2002 (2002-01-01), pages 135 - 138, XP002975040 *
JENNINGS ET AL.: "The use of infrared spectrophotometry for measuring body water spaces", CLINICAL CHEMISTRY, vol. 45, no. 7, July 1999 (1999-07-01), pages 1077 - 1081, XP002975041 *
ROBERTS: "Use of the Doubly lebeled Water Method for Measurement of Energy Expenditure, Total Body Water, Water Intake and Metabolizable Energy Intake in Humans and Small Animals", CANADIAN J OF PHYSIOLOGY AND PHARMACOLOGY, vol. 67, no. 10, October 1989 (1989-10-01), pages 1190 - 1198, XP002975042 *

Also Published As

Publication number Publication date
AU2003253702A1 (en) 2004-01-19
AU2003253702A8 (en) 2004-01-19
WO2004003493A2 (en) 2004-01-08

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