WO2004003167A3 - Gucy1b2 genetic markers for ldl cholesterol response to statin therapy - Google Patents

Gucy1b2 genetic markers for ldl cholesterol response to statin therapy Download PDF

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Publication number
WO2004003167A3
WO2004003167A3 PCT/US2003/020606 US0320606W WO2004003167A3 WO 2004003167 A3 WO2004003167 A3 WO 2004003167A3 US 0320606 W US0320606 W US 0320606W WO 2004003167 A3 WO2004003167 A3 WO 2004003167A3
Authority
WO
WIPO (PCT)
Prior art keywords
gucy1b2
genetic markers
ldl cholesterol
methods
response
Prior art date
Application number
PCT/US2003/020606
Other languages
French (fr)
Other versions
WO2004003167A2 (en
Inventor
Bradley J Dain
Chad Messer
Carol R Reed
Ping Zhan
Original Assignee
Genaissance Pharmaceuticals
Bradley J Dain
Chad Messer
Carol R Reed
Ping Zhan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Bradley J Dain, Chad Messer, Carol R Reed, Ping Zhan filed Critical Genaissance Pharmaceuticals
Priority to AU2003280285A priority Critical patent/AU2003280285A1/en
Publication of WO2004003167A2 publication Critical patent/WO2004003167A2/en
Publication of WO2004003167A3 publication Critical patent/WO2004003167A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Genetic markers in the GUCY1B2 gene associated with LDL cholesterol response to treatment with atorvastatin calcium are disclosed. Compositions and methods for detecting and using these GUCY1B2 genetic markers in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising a statin composition approved for treating patients having one of these GUCY1B2 haplotypes, methods and kits for predicting the response of an individual to a given statin treatment based on their haplotype profile, and methods for treating individuals with hyperlipidemia based on their haplotype profile.
PCT/US2003/020606 2002-06-28 2003-06-30 Gucy1b2 genetic markers for ldl cholesterol response to statin therapy WO2004003167A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003280285A AU2003280285A1 (en) 2002-06-28 2003-06-30 Gucy1b2 genetic markers for ldl cholesterol response to statin therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39281802P 2002-06-28 2002-06-28
US60/392,818 2002-06-28

Publications (2)

Publication Number Publication Date
WO2004003167A2 WO2004003167A2 (en) 2004-01-08
WO2004003167A3 true WO2004003167A3 (en) 2005-02-10

Family

ID=30000940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020606 WO2004003167A2 (en) 2002-06-28 2003-06-30 Gucy1b2 genetic markers for ldl cholesterol response to statin therapy

Country Status (2)

Country Link
AU (1) AU2003280285A1 (en)
WO (1) WO2004003167A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1784504A2 (en) * 2004-07-21 2007-05-16 Institut National De La Sante Et De La Recherche Medicale (Inserm) Oatp-c gene c463a polymorphism underlies variable response of statin therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AHREN, H.: "Biochemical, reagent kits offer scientists good return on investment", THE SCIENTIST, vol. 19, 24 July 1995 (1995-07-24), pages 20 - 24, XP002921157 *
BEHRENDS ET AL.: "The beta2 subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 271, 2000, pages 64 - 69, XP001197340 *
DATABASE GENBANK, ON NCBI [online] XP002904285, Database accession no. (AF038499) *

Also Published As

Publication number Publication date
WO2004003167A2 (en) 2004-01-08
AU2003280285A1 (en) 2004-01-19
AU2003280285A8 (en) 2004-01-19

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