WO2004002357A1 - Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product - Google Patents
Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product Download PDFInfo
- Publication number
- WO2004002357A1 WO2004002357A1 PCT/SE2003/001021 SE0301021W WO2004002357A1 WO 2004002357 A1 WO2004002357 A1 WO 2004002357A1 SE 0301021 W SE0301021 W SE 0301021W WO 2004002357 A1 WO2004002357 A1 WO 2004002357A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- product
- products
- moisture
- arrangement
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000007943 implant Substances 0.000 title claims abstract description 13
- 239000000126 substance Substances 0.000 title claims abstract description 8
- 230000000694 effects Effects 0.000 title claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 230000001419 dependent effect Effects 0.000 claims abstract description 5
- 239000011521 glass Substances 0.000 claims description 26
- 239000003708 ampul Substances 0.000 claims description 24
- 239000007789 gas Substances 0.000 claims description 16
- 238000003466 welding Methods 0.000 claims description 14
- 229910052751 metal Inorganic materials 0.000 claims description 11
- 239000002184 metal Substances 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 10
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 7
- 239000010936 titanium Substances 0.000 claims description 7
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 229910001200 Ferrotitanium Inorganic materials 0.000 claims description 2
- 239000004053 dental implant Substances 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 238000003860 storage Methods 0.000 abstract description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004826 seaming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0087—Means for sterile storage or manipulation of dental implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0095—Packages or dispensers for prostheses or other implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
Definitions
- the present invention relates to an arrangement for a container for preserving, even for a long time, the , new-bone-forming effect of growth-stimulating substances (GS) applied to one or more implant products.
- the container is arranged so as, dependent on being acted upon, to allow accessibility of the product concerned with applied GS at the time of use of the product.
- long time means, for example, periods of several years.
- a GS which is intended to be used on implants, for example dental implants, should be kept in a frozen environment until use on the spot by a surgeon, dentist etc.
- the user in question should then mix ⁇ the frozen molecules with an aqueous solution in order to achieve an appropriate concentration which is to be applied to the product/the implant in question at the point of use.
- the molecules be applied to the product and that the combination of molecules/product be frozen during storage and transport.
- the object of the present invention is to resolve inter alia this problematic situation and to start from the knowledge the storage time for the GS applied to the product is highly dependent on whether or not the GS is exposed to air, water or a moist environment.
- the invention also aims to solve this problem by making possible long storage times in this connection, that is to say storage times of several years.
- An arrangement according to the invention can be considered to be characterized mainly in that the container is arranged to enclose the product or the products with applied GS in an environment which is essentially free from air, water and moisture.
- the container can be in the form of a glass ampoule, or be made of metal which makes the environment free from air, water and moisture possible, for example metal in the form of titanium, stainless steel etc.
- the container can consist of a vacuum container which has an internal pressure for the product or the products with applied GS of ⁇ 10 -4 mbar.
- Said environment can comprise one or more essentially inert gases, for example argon, nitrogen or helium, which in one embodiment are used in connection with evacuation of the container in question.
- a method according to the invention can be considered to be characterized mainly in that the container is made to enclose the product or the products with applied GS in an environment which is essentially free from air, water and moisture.
- the product with associated GS can be applied in a glass tube provided with a bottom, the interior of which is connected to a vacuum pump. After evacuation, a burning means employed can be activated for formation of a closed glass ampoule by sealing the glass tube part enclosing the product with GS.
- a first part or lower part made of foil-shaped metal, for example titanium or stainless steel, can be used. The product is arranged on the first part with associated GS applied.
- a second part or upper part likewise made of foil-shaped metal is applied to the first part or lower part with the product or the products enclosed.
- the space between the parts which is intended for the product or the products is evacuated and/or filled with gas and sealed by means of laser welding or what may be referred to as extended single-spot welding, that is to say welding by means of one stroke along the entire sealing length.
- extended single-spot welding that is to say welding by means of one stroke along the entire sealing length.
- seaming can also be employed as the sealing method.
- Figure 1 shows in the form of a schematic diagram the formation of a glass ampoule with a' product provided with GS introduced, the interior of the glass ampoule being connectable to on the one hand a vacuum pump and on the other hand a gas bottle;
- Figure la shows in principle the sealing function for the glass ampoule
- Figure lb shows in principle a pumping arrangement for a number of ampoules
- Figure 2 shows a horizontal view of a first part or lower part made of metal foil with a compartment for an implant or another product with applied GS;
- Figure 3 shows a vertical section of the first part or lower part according to Figure 2;
- Figure 4 shows a horizontal view from above of a second part or upper part intended to be applied to the first part or lower part and provided with a tear-off strip for uncovering the product with applied GS enclosed by the first and second parts;
- Figure 5 shows a side view of the upper part according to Figure 4.
- Figure 6 shows a horizontal view of the first and second parts in an a joined-together state, the parts having been joined together by means of a welding procedure
- Figure 7 shows a side view of a part of the welding tool for extended single-spot welding which brings about the mutual sealing of the first and second parts with the implant with GS located inside.
- FIG. 1 what will become a glass ampoule is indicated symbolically by 1.
- a vacuum pump of a kind known per se is shown by 2 and a gas container by 3.
- the ampoule is connected to a line system 4 which is indicated schematically.
- the connection of the interior la of the glass ampoule to the line system is effected by means of melting the glass material.
- a manometer 6 Also connected to the system is a manometer 6 in order to make it possible to establish an appropriate pressure in the system.
- the pump 2 is connected to the line system via valve means 7.
- the gas bottle 3 is provided with a regulating valve 8, to which a manometer, here called the second manometer 9, can be connected.
- the gas bottle arrangement can be connected to the line system 4 via a second valve means 9' .
- the product is provided with GS in the manner indicated in the applications filed by the same applicant and inventor.
- patent applications WO 00/72775 and WO 00/72777 by the same applicant as in the present patent application.
- a technique known per se can be used for sealing the ampoule 1.
- the interior of the ampoule is evacuated to a value which is ⁇ 10 ⁇ 4 in the illustrative embodiment.
- the glass ampoule thus evacuated is sealed with the aid of a rotating burner 12 according to Figure 1.
- the burner works with a gas flame 13.
- the glass ampoule 1 is provided with a sealed bottom part lb, and the top part lc is also sealed by means of the gas flame 13.
- the glass ampoule is provided with an indication, it can then be opened by breaking.
- the ampoule is then filled with gas from the gas bottle 3 which is connected via the regulating valve 8 and the valve means 9 to the line system and via the connection valve 5.
- Figure 1 shows a multiple arrangement for a number of glass ampoules.
- Each glass ampoule 15, 16, 17, 18, 19, 20, 21 and 22 is connected internally to a line 23, which can in turn be connected in a manner known per se to said gas bottle 3 and the vacuum pump.
- Products provided with GS can be introduced into the ampoules, after which the latter can be evacuated, filled with gas and sealed in accordance with the above.
- Figures 2-7 show the case when the container consists of two foil-shaped metal parts which can be welded together with one another with the product with GS located inside during simultaneous evacuation of the space for the product in connection with evacuation.
- Figure 2 shows a first part or lower part 24 with a space 25 for a product in the form of an implant 26 which has been coated with GS on its external thread 26a in the way indicated above.
- the space 25 can contain more than one product, which has been symbolized by 27.
- Figure 3 shows the shape of the first part or lower part from the side; the part can be regarded as comprising a space part 28 and a flange part 29.
- Figure 4 shows a second part or upper part which is intended to be joined together with the part according ' to Figures 2 and 3.
- the second part or upper part is indicated by 30 and is provided with a tear-off strip 31.
- the second part or upper part is arranged in a vacuum-tight manner in relation to the lower part by means of welding around the flange part, for example laser welding.
- the tear-off strip has at one of its ends a tab 31a, by means of which it is possible to take hold of the strip and tear the same off from the part 30 in question.
- the tab part 31a has a shape which is easy to grip and facilitates tearing-off of the flap 31 from the part 30.
- Figure 6 shows the case where the second part 30 has been applied to the first part 24.
- Sealing is effected by means of laser welding or the welding stamp 32 shown symbolically in Figure 7 which is arranged to establish a vacuum-tight seal 33 between the parts 24 and 30 by interaction. Sealing is effected at the flange 29 shown in Figure 3. Sealing is effected by a single interaction between the stamp and the parts 30 and 40, and the welding function is referred to here as extended single-spot welding.
- Stamping is preceded by evacuation and in some cases by a subsequent gas- filling of the inner space (compare 25 in Figure 3) of the parts, which evacuation and gas-filling are performed in a symbolically indicated apparatus 34 of a type known per se.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Prostheses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004517441A JP2005531357A (en) | 2002-07-01 | 2003-06-18 | Assembly device and method for preserving the new bone formation effect of growth stimulants for implant products |
EP03761883A EP1519693B1 (en) | 2002-07-01 | 2003-06-18 | Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product |
DE60332020T DE60332020D1 (en) | 2002-07-01 | 2003-06-18 | ARRANGEMENT AND METHOD FOR PRESERVING THE NEW BONE IMPROVING EFFECT OF GROWTH STIMULATORS |
AT03761883T ATE463210T1 (en) | 2002-07-01 | 2003-06-18 | ARRANGEMENT AND METHOD FOR PRESERVING THE NEW BONE-FORMING EFFECT OF GROWTH-STIMULATING SUBSTANCES FOR AN IMPLANTATION PRODUCT |
US10/520,009 US20060091033A1 (en) | 2002-07-01 | 2003-06-18 | Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product |
BR0312386-3A BR0312386A (en) | 2002-07-01 | 2003-06-18 | Arrangement and method for preserving the effect of new bone formation of growth stimulating substances on an implant |
CA002491024A CA2491024A1 (en) | 2002-07-01 | 2003-06-18 | Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product |
AU2003243087A AU2003243087A1 (en) | 2002-07-01 | 2003-06-18 | Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0202052A SE522981C2 (en) | 2002-07-01 | 2002-07-01 | Device and method for maintaining neoplastic effect of growth-stimulating substances in implant product |
SE0202052-7 | 2002-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004002357A1 true WO2004002357A1 (en) | 2004-01-08 |
Family
ID=20288398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2003/001021 WO2004002357A1 (en) | 2002-07-01 | 2003-06-18 | Arrangement and method for preserving the new-boneforming effect of growth-stimulating substances for an implant product |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060091033A1 (en) |
EP (1) | EP1519693B1 (en) |
JP (1) | JP2005531357A (en) |
AT (1) | ATE463210T1 (en) |
AU (1) | AU2003243087A1 (en) |
BR (1) | BR0312386A (en) |
CA (1) | CA2491024A1 (en) |
DE (1) | DE60332020D1 (en) |
SE (1) | SE522981C2 (en) |
WO (1) | WO2004002357A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1712216A1 (en) * | 2005-04-12 | 2006-10-18 | Straumann Holding AG | packaging for a dental product and its appropriate label |
WO2011101167A1 (en) | 2010-02-22 | 2011-08-25 | Straumann Holding Ag | Packaging for an implant |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2346470T3 (en) * | 2008-09-29 | 2013-03-04 | Vifor Int Ag | Container and method for storing and delivering a liquid and a liquid medical preparation |
CN105748169A (en) * | 2016-04-22 | 2016-07-13 | 吴大怡 | Pinhole bone extruding-enlarging device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994003179A1 (en) * | 1992-07-31 | 1994-02-17 | U.S. Bioscience, Inc. | Crystalline amifostine compositions and methods for the preparation and use of same |
EP0811367A2 (en) * | 1996-06-05 | 1997-12-10 | Schott Glaswerke | Glass container particularly for storing pharmaceutical or diagnostic solutions |
WO2000072777A1 (en) * | 1999-05-31 | 2000-12-07 | Nobel Biocare Ab (Publ) | Implant, method for producing the implant, and use of the implant |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04215927A (en) * | 1990-05-04 | 1992-08-06 | Puff Pac Ind Inc | Package system |
US5230427A (en) * | 1991-06-12 | 1993-07-27 | Ppg Industries, Inc. | Sterilizable hermetically-sealed substantially glass container |
DE4317326C1 (en) * | 1993-05-25 | 1994-09-01 | Ver Kunststoffwerke Gmbh | Press-through film for press-through packaging |
CN1607968A (en) * | 2001-11-02 | 2005-04-20 | 梅里迪安医学技术公司 | Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
-
2002
- 2002-07-01 SE SE0202052A patent/SE522981C2/en not_active IP Right Cessation
-
2003
- 2003-06-18 BR BR0312386-3A patent/BR0312386A/en not_active IP Right Cessation
- 2003-06-18 CA CA002491024A patent/CA2491024A1/en not_active Abandoned
- 2003-06-18 JP JP2004517441A patent/JP2005531357A/en active Pending
- 2003-06-18 AU AU2003243087A patent/AU2003243087A1/en not_active Abandoned
- 2003-06-18 DE DE60332020T patent/DE60332020D1/en not_active Expired - Lifetime
- 2003-06-18 AT AT03761883T patent/ATE463210T1/en not_active IP Right Cessation
- 2003-06-18 US US10/520,009 patent/US20060091033A1/en not_active Abandoned
- 2003-06-18 EP EP03761883A patent/EP1519693B1/en not_active Expired - Lifetime
- 2003-06-18 WO PCT/SE2003/001021 patent/WO2004002357A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994003179A1 (en) * | 1992-07-31 | 1994-02-17 | U.S. Bioscience, Inc. | Crystalline amifostine compositions and methods for the preparation and use of same |
EP0811367A2 (en) * | 1996-06-05 | 1997-12-10 | Schott Glaswerke | Glass container particularly for storing pharmaceutical or diagnostic solutions |
WO2000072777A1 (en) * | 1999-05-31 | 2000-12-07 | Nobel Biocare Ab (Publ) | Implant, method for producing the implant, and use of the implant |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1712216A1 (en) * | 2005-04-12 | 2006-10-18 | Straumann Holding AG | packaging for a dental product and its appropriate label |
US7337896B2 (en) | 2005-04-12 | 2008-03-04 | Straumann Holding Ag | Package for dental product, with a label assigned to the product |
WO2011101167A1 (en) | 2010-02-22 | 2011-08-25 | Straumann Holding Ag | Packaging for an implant |
Also Published As
Publication number | Publication date |
---|---|
JP2005531357A (en) | 2005-10-20 |
EP1519693B1 (en) | 2010-04-07 |
EP1519693A1 (en) | 2005-04-06 |
DE60332020D1 (en) | 2010-05-20 |
CA2491024A1 (en) | 2004-01-08 |
ATE463210T1 (en) | 2010-04-15 |
US20060091033A1 (en) | 2006-05-04 |
SE522981C2 (en) | 2004-03-23 |
AU2003243087A1 (en) | 2004-01-19 |
BR0312386A (en) | 2005-04-12 |
SE0202052D0 (en) | 2002-07-01 |
SE0202052L (en) | 2004-01-02 |
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