WO2004000847A1 - A process for the preparation of olanzapine and an intermediate therefor - Google Patents
A process for the preparation of olanzapine and an intermediate therefor Download PDFInfo
- Publication number
- WO2004000847A1 WO2004000847A1 PCT/IB2003/002181 IB0302181W WO2004000847A1 WO 2004000847 A1 WO2004000847 A1 WO 2004000847A1 IB 0302181 W IB0302181 W IB 0302181W WO 2004000847 A1 WO2004000847 A1 WO 2004000847A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- process according
- methyl
- methylation
- borohydride
- demethylolanzapine
- Prior art date
Links
- JGRCIHJNXMWXOC-UHFFFAOYSA-N Cc1cc(C(CN(CC2)CCN2C=O)=Nc(cccc2)c2N2)c2[s]1 Chemical compound Cc1cc(C(CN(CC2)CCN2C=O)=Nc(cccc2)c2N2)c2[s]1 JGRCIHJNXMWXOC-UHFFFAOYSA-N 0.000 description 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N Cc1cc(C(N2CCN(C)CC2)=Nc(cccc2)c2N2)c2[s]1 Chemical compound Cc1cc(C(N2CCN(C)CC2)=Nc(cccc2)c2N2)c2[s]1 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200330991T SI1513845T2 (en) | 2002-06-20 | 2003-06-10 | A process for the preparation of olanzapine and an intermediate therefor |
MXPA04012200A MXPA04012200A (en) | 2002-06-20 | 2003-06-10 | A process for the preparation of olanzapine and an intermediate therefor. |
EP03732782A EP1513845B2 (en) | 2002-06-20 | 2003-06-10 | A process for the preparation of olanzapine and an intermediate therefor |
AU2003240167A AU2003240167A1 (en) | 2002-06-20 | 2003-06-10 | A process for the preparation of olanzapine and an intermediate therefor |
DE60316439T DE60316439T3 (en) | 2002-06-20 | 2003-06-10 | PROCESS FOR THE PRODUCTION OF OLANZAPINE AND A INTERMEDIATE PRODUCT THEREFOR |
BR0305100-5A BR0305100A (en) | 2002-06-20 | 2003-06-10 | Process for the preparation of olanzapine |
UA20041109317A UA76616C2 (en) | 2002-06-20 | 2003-10-06 | Process for the preparation of olanzapine and intermediary product thereof |
NO20040658A NO328873B1 (en) | 2002-06-20 | 2004-02-13 | Precursor feed for the preparation of olanzapine. |
TNP2004000226A TNSN04226A1 (en) | 2002-06-20 | 2004-11-17 | A process for the preparation of olanzapine and an intermediate therefor |
HR20041075A HRP20041075B1 (en) | 2002-06-20 | 2004-11-17 | A process for the preparation of olanzapine and an intermediate therefor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL354642A PL199016B1 (en) | 2002-06-20 | 2002-06-20 | Method of manufacture of alanzapine, new derivative of n-demethyl olanzapine and method of manufacture of new derivative of n-demethyl olanzapine |
PLP-354642 | 2002-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004000847A1 true WO2004000847A1 (en) | 2003-12-31 |
Family
ID=29997625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/002181 WO2004000847A1 (en) | 2002-06-20 | 2003-06-10 | A process for the preparation of olanzapine and an intermediate therefor |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP1513845B2 (en) |
CN (1) | CN100338069C (en) |
AT (2) | ATE371660T1 (en) |
AU (1) | AU2003240167A1 (en) |
BR (1) | BR0305100A (en) |
DE (2) | DE60316439T3 (en) |
ES (2) | ES2291644T5 (en) |
HR (1) | HRP20041075B1 (en) |
MX (1) | MXPA04012200A (en) |
NO (1) | NO328873B1 (en) |
PL (1) | PL199016B1 (en) |
PT (2) | PT1513845E (en) |
RU (1) | RU2005101324A (en) |
SI (2) | SI1669359T1 (en) |
TN (1) | TNSN04226A1 (en) |
UA (1) | UA76616C2 (en) |
WO (1) | WO2004000847A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
WO2005070938A1 (en) | 2004-01-27 | 2005-08-04 | Synthon B.V. | Stable salts of olanzapine |
WO2006053870A1 (en) | 2004-11-22 | 2006-05-26 | Adamed Sp. Z O.O. | A process for the preparation of n-demethylolanzapine |
EP1749010A2 (en) * | 2004-03-18 | 2007-02-07 | LEK Pharmaceuticals D.D. | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno 2, 3-b 1,5 benzodiazepine and salts thereof |
US7323459B2 (en) | 2002-12-24 | 2008-01-29 | Teva Pharmaceutical Industries Ltd. | Crystal forms, methods for their preparation and method for preparation of olanzapine |
CN100383144C (en) * | 2006-09-11 | 2008-04-23 | 杭州盛美医药科技开发有限公司 | Intermediate of olanzapine, preparation and application thereof |
EP2264016A2 (en) | 2004-07-14 | 2010-12-22 | Jubilant Organosys Limited | A process for producing pure form form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10h-thieno[2,3-B][1,5] benzodiazepine |
WO2011009831A1 (en) | 2009-07-20 | 2011-01-27 | Lek Pharmaceuticals D.D. | Process for the purification of olanzapine |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102234285B (en) * | 2010-04-19 | 2013-06-12 | 江苏豪森药业股份有限公司 | Preparation method of olanzapine |
CN102924470B (en) * | 2011-08-31 | 2014-12-03 | 江苏豪森药业股份有限公司 | Novel olanzapine preparation method |
CN102942573B (en) * | 2011-10-09 | 2015-03-25 | 连云港恒运医药科技有限公司 | Preparation method of olanzapine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1533235A (en) * | 1974-11-26 | 1978-11-22 | Lilly Industries Ltd | Benzodiazepine derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7306069A (en) † | 1973-05-02 | 1974-11-05 | ||
US4115568A (en) † | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
US5239071A (en) † | 1989-11-21 | 1993-08-24 | The B. F. Goodrich Company | Process for methylating a hindered nitrogen atom in an inert non-aqueous solvent |
GB9009229D0 (en) | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
DK55192D0 (en) † | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindene derivatives |
WO2000030650A1 (en) | 1998-11-23 | 2000-06-02 | Sepracor Inc. | Desmethylolanzapine compositions and methods |
-
2002
- 2002-06-20 PL PL354642A patent/PL199016B1/en unknown
-
2003
- 2003-06-10 SI SI200330985T patent/SI1669359T1/en unknown
- 2003-06-10 AT AT06100356T patent/ATE371660T1/en not_active IP Right Cessation
- 2003-06-10 BR BR0305100-5A patent/BR0305100A/en not_active IP Right Cessation
- 2003-06-10 ES ES03732782T patent/ES2291644T5/en not_active Expired - Lifetime
- 2003-06-10 DE DE60316439T patent/DE60316439T3/en not_active Expired - Lifetime
- 2003-06-10 RU RU2005101324/04A patent/RU2005101324A/en not_active Application Discontinuation
- 2003-06-10 ES ES06100356T patent/ES2289730T3/en not_active Expired - Lifetime
- 2003-06-10 EP EP03732782A patent/EP1513845B2/en not_active Expired - Lifetime
- 2003-06-10 EP EP06100356A patent/EP1669359B1/en not_active Expired - Lifetime
- 2003-06-10 CN CNB038141655A patent/CN100338069C/en not_active Ceased
- 2003-06-10 MX MXPA04012200A patent/MXPA04012200A/en not_active Application Discontinuation
- 2003-06-10 AU AU2003240167A patent/AU2003240167A1/en not_active Abandoned
- 2003-06-10 DE DE60316047T patent/DE60316047T2/en not_active Expired - Fee Related
- 2003-06-10 SI SI200330991T patent/SI1513845T2/en unknown
- 2003-06-10 PT PT03732782T patent/PT1513845E/en unknown
- 2003-06-10 PT PT06100356T patent/PT1669359E/en unknown
- 2003-06-10 WO PCT/IB2003/002181 patent/WO2004000847A1/en active IP Right Grant
- 2003-06-10 AT AT03732782T patent/ATE373664T1/en not_active IP Right Cessation
- 2003-10-06 UA UA20041109317A patent/UA76616C2/en unknown
-
2004
- 2004-02-13 NO NO20040658A patent/NO328873B1/en not_active IP Right Cessation
- 2004-11-17 TN TNP2004000226A patent/TNSN04226A1/en unknown
- 2004-11-17 HR HR20041075A patent/HRP20041075B1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1533235A (en) * | 1974-11-26 | 1978-11-22 | Lilly Industries Ltd | Benzodiazepine derivatives |
Non-Patent Citations (1)
Title |
---|
CALLIGARO D O ET AL: "The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 1, 7 January 1997 (1997-01-07), pages 25 - 30, XP004135960, ISSN: 0960-894X * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7323459B2 (en) | 2002-12-24 | 2008-01-29 | Teva Pharmaceutical Industries Ltd. | Crystal forms, methods for their preparation and method for preparation of olanzapine |
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
WO2005070938A1 (en) | 2004-01-27 | 2005-08-04 | Synthon B.V. | Stable salts of olanzapine |
US7329747B2 (en) | 2004-01-27 | 2008-02-12 | Synthon Ip Inc. | Synthesis of olanzapine and intermediates thereof |
US7459449B2 (en) | 2004-01-27 | 2008-12-02 | Rolf Keltjens | Stable salts of olanzapine |
EP1749010A2 (en) * | 2004-03-18 | 2007-02-07 | LEK Pharmaceuticals D.D. | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno 2, 3-b 1,5 benzodiazepine and salts thereof |
EP2264016A2 (en) | 2004-07-14 | 2010-12-22 | Jubilant Organosys Limited | A process for producing pure form form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10h-thieno[2,3-B][1,5] benzodiazepine |
WO2006053870A1 (en) | 2004-11-22 | 2006-05-26 | Adamed Sp. Z O.O. | A process for the preparation of n-demethylolanzapine |
EP1988092A1 (en) | 2004-11-22 | 2008-11-05 | Adamed Sp. z o.o. | A process for the preparation of olanzapine |
CN100383144C (en) * | 2006-09-11 | 2008-04-23 | 杭州盛美医药科技开发有限公司 | Intermediate of olanzapine, preparation and application thereof |
WO2011009831A1 (en) | 2009-07-20 | 2011-01-27 | Lek Pharmaceuticals D.D. | Process for the purification of olanzapine |
EP2292624A1 (en) | 2009-07-20 | 2011-03-09 | LEK Pharmaceuticals d.d. | Process for the purification of olanzapine |
Also Published As
Publication number | Publication date |
---|---|
EP1669359A1 (en) | 2006-06-14 |
EP1669359B1 (en) | 2007-08-29 |
DE60316047T2 (en) | 2008-05-21 |
DE60316439T3 (en) | 2011-05-05 |
NO20040658L (en) | 2004-02-13 |
DE60316439T2 (en) | 2008-07-31 |
EP1513845B1 (en) | 2007-09-19 |
AU2003240167A1 (en) | 2004-01-06 |
MXPA04012200A (en) | 2005-08-26 |
PL354642A1 (en) | 2003-12-29 |
UA76616C2 (en) | 2006-08-15 |
BR0305100A (en) | 2004-09-28 |
NO328873B1 (en) | 2010-06-07 |
PT1669359E (en) | 2007-10-16 |
TNSN04226A1 (en) | 2007-03-12 |
CN100338069C (en) | 2007-09-19 |
PL199016B1 (en) | 2008-08-29 |
HRP20041075A2 (en) | 2005-02-28 |
ES2291644T3 (en) | 2008-03-01 |
ATE373664T1 (en) | 2007-10-15 |
PT1513845E (en) | 2007-11-21 |
RU2005101324A (en) | 2005-08-10 |
SI1513845T2 (en) | 2011-01-31 |
EP1513845B2 (en) | 2010-11-03 |
EP1513845A1 (en) | 2005-03-16 |
DE60316047D1 (en) | 2007-10-11 |
ES2289730T3 (en) | 2008-02-01 |
ES2291644T5 (en) | 2011-02-15 |
CN1662543A (en) | 2005-08-31 |
ATE371660T1 (en) | 2007-09-15 |
DE60316439D1 (en) | 2007-10-31 |
SI1513845T1 (en) | 2007-12-31 |
SI1669359T1 (en) | 2007-12-31 |
HRP20041075B1 (en) | 2008-05-31 |
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