WO2003105891A3 - Use of hec1 antagonists in the treatment of proliferative disorders and cancer - Google Patents
Use of hec1 antagonists in the treatment of proliferative disorders and cancer Download PDFInfo
- Publication number
- WO2003105891A3 WO2003105891A3 PCT/EP2003/006205 EP0306205W WO03105891A3 WO 2003105891 A3 WO2003105891 A3 WO 2003105891A3 EP 0306205 W EP0306205 W EP 0306205W WO 03105891 A3 WO03105891 A3 WO 03105891A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hec1
- antagonists
- cancer
- treatment
- proliferative disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003250831A AU2003250831A1 (en) | 2002-06-12 | 2003-06-12 | Use of hec1 antagonists in the treatment of proliferative disorders and cancer |
EP03759949A EP1519736A2 (en) | 2002-06-12 | 2003-06-12 | Use of hec1 antagonists in the treatment of proliferative disorders and cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02013006 | 2002-06-12 | ||
EP02013006.8 | 2002-06-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003105891A2 WO2003105891A2 (en) | 2003-12-24 |
WO2003105891A3 true WO2003105891A3 (en) | 2004-05-06 |
Family
ID=29724387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/006205 WO2003105891A2 (en) | 2002-06-12 | 2003-06-12 | Use of hec1 antagonists in the treatment of proliferative disorders and cancer |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1519736A2 (en) |
AU (1) | AU2003250831A1 (en) |
WO (1) | WO2003105891A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101234281B1 (en) | 2004-04-09 | 2013-02-18 | 가부시키가이샤 진케어켄큐쇼 | Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associated genes |
JO3000B1 (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
AU2006330084A1 (en) * | 2005-09-30 | 2007-07-05 | The Regents Of The University Of California | SATB1: a determinant of morphogenesis and tumor metastatis |
ES2537323T3 (en) | 2007-08-20 | 2015-06-05 | Oncotherapy Science, Inc. | CDCA1 peptide and pharmaceutical agent comprising it |
TWI526219B (en) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Cdca1 epitope peptides and vaccines containing the same |
KR101609856B1 (en) | 2010-03-17 | 2016-04-07 | 타이벡스 세라피틱스 코포레이션 | Modulators of hec1 activity and methods therefor |
SG10201506881PA (en) * | 2011-11-21 | 2015-10-29 | Taivex Therapeutics Corp | Biomarkers for cancers responsive to modulators of hec1 activity |
US11071736B2 (en) | 2011-11-21 | 2021-07-27 | Taivex Therapeutics Corporation | Modulators of HEC1 activity and methods therefor |
TWI640519B (en) | 2011-11-29 | 2018-11-11 | 泰緯生命科技股份有限公司 | Modulators of hec1 activity and methods therefor |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045433A1 (en) * | 1997-04-04 | 1998-10-15 | Board Of Regents, The University Of Texas System | Proteins and compositions for modulating mitosis |
-
2003
- 2003-06-12 EP EP03759949A patent/EP1519736A2/en not_active Withdrawn
- 2003-06-12 WO PCT/EP2003/006205 patent/WO2003105891A2/en not_active Application Discontinuation
- 2003-06-12 AU AU2003250831A patent/AU2003250831A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045433A1 (en) * | 1997-04-04 | 1998-10-15 | Board Of Regents, The University Of Texas System | Proteins and compositions for modulating mitosis |
Non-Patent Citations (6)
Title |
---|
CHEN Y ET AL: "HEC, A NOVEL NUCLEAR PROTEIN RICH IN LEUCINE HEPTAD REPEATS SPECIFICALLY INVOLVED IN MITOSIS", MOLECULAR AND CELLULAR BIOLOGY, WASHINGTON, DC, US, vol. 17, no. 10, 1 October 1997 (1997-10-01), pages 6049 - 6056, XP002068137, ISSN: 0270-7306 * |
MARTIN-LLUESMA SILVIA ET AL: "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2", SCIENCE (WASHINGTON D C), vol. 297, no. 5590, 27 September 2002 (2002-09-27), pages 2267 - 2270, XP002263374, ISSN: 0036-8075 * |
MOSS ERIC G: "RNA interference: It's a small RNA world", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 11, no. 19, 2001, pages R772 - R775, XP002183121, ISSN: 0960-9822 * |
UEDA R: "RNAI: A NEW TECHNOLOGY IN THE POST-GENOMIC SEQUENCING ERA", JOURNAL OF NEUROGENETICS, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 3/4, 2001, pages 193 - 204, XP001147227, ISSN: 0167-7063 * |
WIGGE PHILIP A ET AL: "Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry", JOURNAL OF CELL BIOLOGY, vol. 141, no. 4, 18 May 1998 (1998-05-18), pages 967 - 977, XP002263373, ISSN: 0021-9525 * |
WIGGE PHILIP A ET AL: "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation", JOURNAL OF CELL BIOLOGY, vol. 152, no. 2, 22 January 2001 (2001-01-22), pages 349 - 360, XP002263372, ISSN: 0021-9525 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003250831A1 (en) | 2003-12-31 |
WO2003105891A2 (en) | 2003-12-24 |
EP1519736A2 (en) | 2005-04-06 |
AU2003250831A8 (en) | 2003-12-31 |
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