WO2003102201A3 - Methods and materials for the production of d-lactic acid in yeast - Google Patents

Methods and materials for the production of d-lactic acid in yeast Download PDF

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Publication number
WO2003102201A3
WO2003102201A3 PCT/US2003/017310 US0317310W WO03102201A3 WO 2003102201 A3 WO2003102201 A3 WO 2003102201A3 US 0317310 W US0317310 W US 0317310W WO 03102201 A3 WO03102201 A3 WO 03102201A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
methods
lactic acid
yeast
materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/017310
Other languages
French (fr)
Other versions
WO2003102201A2 (en
Inventor
Vineet Rajgarhia
Catherine Asleson Dundon
Stacey Olson
Pirkko Suominen
Ben Hause
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NatureWorks LLC
Original Assignee
Cargill Dow LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Dow LLC filed Critical Cargill Dow LLC
Priority to JP2004510438A priority Critical patent/JP2005528112A/en
Priority to CN038172941A priority patent/CN1735683B/en
Priority to DE60315028T priority patent/DE60315028T2/en
Priority to CA002487296A priority patent/CA2487296A1/en
Priority to EP03731489A priority patent/EP1513923B1/en
Priority to BR0311453-8A priority patent/BR0311453A/en
Priority to UA20041210933A priority patent/UA80976C2/en
Priority to AU2003240481A priority patent/AU2003240481B8/en
Publication of WO2003102201A2 publication Critical patent/WO2003102201A2/en
Publication of WO2003102201A3 publication Critical patent/WO2003102201A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Kluyveromyces cells, methods for making the Kluyveromyces cells, and their use in production of organic products, particularly D-lactic acid.
PCT/US2003/017310 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast Ceased WO2003102201A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2004510438A JP2005528112A (en) 2002-05-30 2003-05-30 Method for producing D-lactic acid in yeast and its material
CN038172941A CN1735683B (en) 2002-05-30 2003-05-30 Methods and materials for producing D-lactic acid in yeast
DE60315028T DE60315028T2 (en) 2002-05-30 2003-05-30 METHOD AND MATERIALS FOR THE PRODUCTION OF D-MILKY ACID IN YEAST
CA002487296A CA2487296A1 (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
EP03731489A EP1513923B1 (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
BR0311453-8A BR0311453A (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
UA20041210933A UA80976C2 (en) 2002-05-30 2003-05-30 Processes and materials for production of d-lactic acid in yeast
AU2003240481A AU2003240481B8 (en) 2002-05-30 2003-05-30 Methods and materials for the production of D-lactic acid in yeast

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38433302P 2002-05-30 2002-05-30
US60/384,333 2002-05-30

Publications (2)

Publication Number Publication Date
WO2003102201A2 WO2003102201A2 (en) 2003-12-11
WO2003102201A3 true WO2003102201A3 (en) 2004-03-18

Family

ID=29712012

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/017329 Ceased WO2003102152A2 (en) 2002-05-30 2003-05-30 Methods and materials for the production of lactic acid in yeast
PCT/US2003/017310 Ceased WO2003102201A2 (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
PCT/US2003/016825 Ceased WO2003102200A2 (en) 2002-05-30 2003-05-30 Fermentation process using specific oxygen uptake rates as a process control

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017329 Ceased WO2003102152A2 (en) 2002-05-30 2003-05-30 Methods and materials for the production of lactic acid in yeast

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/016825 Ceased WO2003102200A2 (en) 2002-05-30 2003-05-30 Fermentation process using specific oxygen uptake rates as a process control

Country Status (15)

Country Link
US (7) US7232664B2 (en)
EP (4) EP1513939B1 (en)
JP (4) JP4318638B2 (en)
CN (4) CN100335626C (en)
AT (1) ATE367436T1 (en)
AU (4) AU2003243366B2 (en)
BR (4) BR0311453A (en)
CA (3) CA2488196A1 (en)
DE (1) DE60315028T2 (en)
DK (1) DK2878675T3 (en)
ES (3) ES2642928T3 (en)
PT (1) PT1513923E (en)
UA (2) UA88437C2 (en)
WO (3) WO2003102152A2 (en)
ZA (3) ZA200409530B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534597B2 (en) 2002-05-30 2009-05-19 Cargill, Inc. Methods and materials for the production of L-lactic acid in yeast

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