WO2003102097A8 - The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole - Google Patents

The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole

Info

Publication number
WO2003102097A8
WO2003102097A8 PCT/DK2003/000341 DK0300341W WO03102097A8 WO 2003102097 A8 WO2003102097 A8 WO 2003102097A8 DK 0300341 W DK0300341 W DK 0300341W WO 03102097 A8 WO03102097 A8 WO 03102097A8
Authority
WO
WIPO (PCT)
Prior art keywords
tetrahydropyridin
indol
indole
dihydro
acetyl
Prior art date
Application number
PCT/DK2003/000341
Other languages
French (fr)
Other versions
WO2003102097A1 (en
Inventor
Benny Bang-Andersen
Ole Nielsen
De Diego Heidi Lopez
Gitte Ludvig
Original Assignee
Lundbeck & Co As H
Benny Bang-Andersen
Ole Nielsen
De Diego Heidi Lopez
Gitte Ludvig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H, Benny Bang-Andersen, Ole Nielsen, De Diego Heidi Lopez, Gitte Ludvig filed Critical Lundbeck & Co As H
Priority to AU2003236207A priority Critical patent/AU2003236207A1/en
Publication of WO2003102097A1 publication Critical patent/WO2003102097A1/en
Publication of WO2003102097A8 publication Critical patent/WO2003102097A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A hydrochloride of (S)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1H-indole and hydrates and/or solvates thereof, a method for the preparation thereof and the use thereof for the preparation of a pharmaceutical composition.
PCT/DK2003/000341 2002-05-31 2003-05-22 The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole WO2003102097A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003236207A AU2003236207A1 (en) 2002-05-31 2003-05-22 The hydrochloride of (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38446602P 2002-05-31 2002-05-31
DKPA200200843 2002-05-31
DKPA200200843 2002-05-31
US60/384,466 2002-05-31

Publications (2)

Publication Number Publication Date
WO2003102097A1 WO2003102097A1 (en) 2003-12-11
WO2003102097A8 true WO2003102097A8 (en) 2004-12-29

Family

ID=29713303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000341 WO2003102097A1 (en) 2002-05-31 2003-05-22 The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole

Country Status (2)

Country Link
AU (1) AU2003236207A1 (en)
WO (1) WO2003102097A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023201423A1 (en) * 2022-04-19 2023-10-26 Mindset Pharma Inc. Indoline derivatives as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
AR028685A1 (en) * 2000-06-14 2003-05-21 Lundbeck & Co As H INDOL DERIVATIVES
AR033287A1 (en) * 2001-05-09 2003-12-10 Lundbeck & Co As H ADHD TREATMENT

Also Published As

Publication number Publication date
WO2003102097A1 (en) 2003-12-11
AU2003236207A8 (en) 2003-12-19
AU2003236207A1 (en) 2003-12-19

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