WO2003101405A3 - Antibiotiques a base d'amino-glycosides et procedes d'utilisation correspondants - Google Patents

Antibiotiques a base d'amino-glycosides et procedes d'utilisation correspondants Download PDF

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Publication number
WO2003101405A3
WO2003101405A3 PCT/US2003/007930 US0307930W WO03101405A3 WO 2003101405 A3 WO2003101405 A3 WO 2003101405A3 US 0307930 W US0307930 W US 0307930W WO 03101405 A3 WO03101405 A3 WO 03101405A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
same
aminoglycoside antibiotics
relates
present
Prior art date
Application number
PCT/US2003/007930
Other languages
English (en)
Other versions
WO2003101405A2 (fr
Inventor
Robert R Rando
Original Assignee
Harvard College
Robert R Rando
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Robert R Rando filed Critical Harvard College
Priority to AU2003267948A priority Critical patent/AU2003267948A1/en
Publication of WO2003101405A2 publication Critical patent/WO2003101405A2/fr
Priority to US10/941,623 priority patent/US7244712B2/en
Publication of WO2003101405A3 publication Critical patent/WO2003101405A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés à base d'aminoglycosides possédant une activité antibiotique. En outre, la présente invention concerne des composés à base de L-aminoglycosides et de leurs diastéréoimères qui ont une activité antibiotique et ne sont pas vulnérables au développement de souches bactériennes. La présente invention concerne aussi des procédés de traitement et des compositions pharmaceutiques qui utilisent ou comprennent un ou plusieurs composés à base d'aminoglycosides décrits dans l'invention.
PCT/US2003/007930 2002-03-14 2003-03-14 Antibiotiques a base d'amino-glycosides et procedes d'utilisation correspondants WO2003101405A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003267948A AU2003267948A1 (en) 2002-03-14 2003-03-14 Aminoglycoside antibiotics and methods of using same
US10/941,623 US7244712B2 (en) 2003-03-14 2004-09-14 Aminoglycoside antibiotics and methods of using same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36434002P 2002-03-14 2002-03-14
US60/364,340 2002-03-14
US39476302P 2002-07-10 2002-07-10
US60/394,763 2002-07-10

Publications (2)

Publication Number Publication Date
WO2003101405A2 WO2003101405A2 (fr) 2003-12-11
WO2003101405A3 true WO2003101405A3 (fr) 2004-11-25

Family

ID=29715127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/007930 WO2003101405A2 (fr) 2002-03-14 2003-03-14 Antibiotiques a base d'amino-glycosides et procedes d'utilisation correspondants

Country Status (2)

Country Link
AU (1) AU2003267948A1 (fr)
WO (1) WO2003101405A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0411948D0 (en) * 2004-05-28 2004-06-30 Univ Leeds Compounds
JP5256043B2 (ja) 2005-12-02 2013-08-07 アイシス ファーマシューティカルズ， インコーポレーテッド 複数の置換基を有する抗菌４，５−置換アミノグリコシドアナログ
WO2010030690A1 (fr) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Analogues d'aminoglycosides 4,6-substitués et modifiés aux positions 6',6" et 1 possédant une activité antibactérienne
WO2010030704A2 (fr) 2008-09-10 2010-03-18 Achaogen, Inc. Analogues d’aminoglycosides antibactériens
WO2010042851A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d’aminoglycoside antibactériens
WO2010042850A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
MX2012004036A (es) 2009-10-09 2012-06-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos.
TW201304784A (zh) 2010-11-17 2013-02-01 Achaogen Inc 抗菌性胺基糖苷類似物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008362A (en) * 1972-08-25 1977-02-15 Meiji Seika Kaisha, Ltd. 1-N-((S)-α-substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof
US4065616A (en) * 1975-08-15 1977-12-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Processes for production of a 1-N-(α-hydroxy-Φ-amino alkanoyl)-3-deoxy-5-O-pentafuranosyl neamine and new compounds produced by the same processes
US4252970A (en) * 1977-09-06 1981-02-24 The Upjohn Company 6-Deoxyneamines
US4281107A (en) * 1976-05-28 1981-07-28 Suami T Neamine derivatives and process for preparing the same
US6482802B1 (en) * 1998-05-11 2002-11-19 Endowment For Research In Human Biology, Inc. Use of neomycin for treating angiogenesis-related diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008362A (en) * 1972-08-25 1977-02-15 Meiji Seika Kaisha, Ltd. 1-N-((S)-α-substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof
US4065616A (en) * 1975-08-15 1977-12-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Processes for production of a 1-N-(α-hydroxy-Φ-amino alkanoyl)-3-deoxy-5-O-pentafuranosyl neamine and new compounds produced by the same processes
US4281107A (en) * 1976-05-28 1981-07-28 Suami T Neamine derivatives and process for preparing the same
US4252970A (en) * 1977-09-06 1981-02-24 The Upjohn Company 6-Deoxyneamines
US6482802B1 (en) * 1998-05-11 2002-11-19 Endowment For Research In Human Biology, Inc. Use of neomycin for treating angiogenesis-related diseases

Also Published As

Publication number Publication date
AU2003267948A1 (en) 2003-12-19
AU2003267948A8 (en) 2003-12-19
WO2003101405A2 (fr) 2003-12-11

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