WO2003100094A3 - Method for determining the influence of a compound on cholesterol transport - Google Patents

Method for determining the influence of a compound on cholesterol transport Download PDF

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Publication number
WO2003100094A3
WO2003100094A3 PCT/IB2003/002586 IB0302586W WO03100094A3 WO 2003100094 A3 WO2003100094 A3 WO 2003100094A3 IB 0302586 W IB0302586 W IB 0302586W WO 03100094 A3 WO03100094 A3 WO 03100094A3
Authority
WO
WIPO (PCT)
Prior art keywords
influence
compound
determining
cholesterol transport
cholesterol
Prior art date
Application number
PCT/IB2003/002586
Other languages
French (fr)
Other versions
WO2003100094A2 (en
Inventor
Titus Jan Kaletta
Katherine An Hilde Mortier
Original Assignee
Devgen Nv
Titus Jan Kaletta
Katherine An Hilde Mortier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen Nv, Titus Jan Kaletta, Katherine An Hilde Mortier filed Critical Devgen Nv
Priority to AU2003239706A priority Critical patent/AU2003239706A1/en
Publication of WO2003100094A2 publication Critical patent/WO2003100094A2/en
Publication of WO2003100094A3 publication Critical patent/WO2003100094A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G01N2333/43534—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to methods for determining the influence of a compound on cholesterol handling, and in particular on cholesterol transport across biological membranes. In particular, the invention relates to a method for determining the influence of a compound on the uptake of cholesterol by a nematode worm, which method is representative for cholesterol transport across (other) biological membranes.
PCT/IB2003/002586 2002-05-23 2003-05-22 Method for determining the influence of a compound on cholesterol transport WO2003100094A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003239706A AU2003239706A1 (en) 2002-05-23 2003-05-22 Method for determining the influence of a compound on cholesterol transport

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38271402P 2002-05-23 2002-05-23
US60/382,714 2002-05-23

Publications (2)

Publication Number Publication Date
WO2003100094A2 WO2003100094A2 (en) 2003-12-04
WO2003100094A3 true WO2003100094A3 (en) 2004-01-29

Family

ID=29584446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/002586 WO2003100094A2 (en) 2002-05-23 2003-05-22 Method for determining the influence of a compound on cholesterol transport

Country Status (2)

Country Link
AU (1) AU2003239706A1 (en)
WO (1) WO2003100094A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135556B2 (en) 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
CA2553769C (en) 2004-01-16 2011-01-04 Merck & Co., Inc. Npc1l1 (npc3) and methods of identifying ligands thereof
US7910698B2 (en) 2006-02-24 2011-03-22 Schering Corporation NPC1L1 orthologues

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001846A2 (en) * 1998-07-03 2000-01-13 Devgen N.V. Characterisation of gene function using double stranded rna inhibition
WO2001088533A2 (en) * 2000-05-19 2001-11-22 Devgen Nv Lipid uptake assays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001846A2 (en) * 1998-07-03 2000-01-13 Devgen N.V. Characterisation of gene function using double stranded rna inhibition
WO2001088533A2 (en) * 2000-05-19 2001-11-22 Devgen Nv Lipid uptake assays

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MATYASH V ET AL: "DISTRIBUTION AND TRANSPORT OF CHOLESTEROL IN CAENORHABDITIS ELEGANS", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 12, no. 6, June 2001 (2001-06-01), pages 1725 - 1736, XP001048139, ISSN: 1059-1524 *
SHIM YHONG-HEE ET AL: "Role of cholesterol in germ-line development of Caenorhabditis elegans", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 61, no. 3, March 2002 (2002-03-01), pages 358 - 366, XP009021684, ISSN: 1040-452X *

Also Published As

Publication number Publication date
AU2003239706A1 (en) 2003-12-12
AU2003239706A8 (en) 2003-12-12
WO2003100094A2 (en) 2003-12-04

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