WO2003100088A3 - Procede et necessaire permettant de mesurer l'activite mitochondriale de lymphocytes humains - Google Patents

Procede et necessaire permettant de mesurer l'activite mitochondriale de lymphocytes humains Download PDF

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Publication number
WO2003100088A3
WO2003100088A3 PCT/IT2003/000239 IT0300239W WO03100088A3 WO 2003100088 A3 WO2003100088 A3 WO 2003100088A3 IT 0300239 W IT0300239 W IT 0300239W WO 03100088 A3 WO03100088 A3 WO 03100088A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitochondrial activity
kit
human lymphocytes
measuring mitochondrial
measuring
Prior art date
Application number
PCT/IT2003/000239
Other languages
English (en)
Other versions
WO2003100088A2 (fr
Inventor
Giorgio Lenaz
Carla Bovina
Original Assignee
Univ Bologna
Giorgio Lenaz
Carla Bovina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bologna, Giorgio Lenaz, Carla Bovina filed Critical Univ Bologna
Priority to AU2003230209A priority Critical patent/AU2003230209A1/en
Publication of WO2003100088A2 publication Critical patent/WO2003100088A2/fr
Publication of WO2003100088A3 publication Critical patent/WO2003100088A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/5052—Cells of the immune system involving B-cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un procédé permettant de mesurer l'activité mitochondriale de lymphocytes humains circulants. Cette invention se rapporte en outre à un nécessaire de diagnostic qui sert à mesurer l'activité mitochondriale de ces lymphocytes.
PCT/IT2003/000239 2002-05-28 2003-04-15 Procede et necessaire permettant de mesurer l'activite mitochondriale de lymphocytes humains WO2003100088A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003230209A AU2003230209A1 (en) 2002-05-28 2003-04-15 Method and kit for measuring mitochondrial activity in human lymphocytes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2002A001147 2002-05-28
IT2002MI001147A ITMI20021147A1 (it) 2002-05-28 2002-05-28 Metodo per la determinazione della funzionalita' mitocondriale in linfociti umani e relativo kit

Publications (2)

Publication Number Publication Date
WO2003100088A2 WO2003100088A2 (fr) 2003-12-04
WO2003100088A3 true WO2003100088A3 (fr) 2004-01-15

Family

ID=11449987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2003/000239 WO2003100088A2 (fr) 2002-05-28 2003-04-15 Procede et necessaire permettant de mesurer l'activite mitochondriale de lymphocytes humains

Country Status (3)

Country Link
AU (1) AU2003230209A1 (fr)
IT (1) ITMI20021147A1 (fr)
WO (1) WO2003100088A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2579317C1 (ru) * 2014-12-25 2016-04-10 Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" СО РАМН Способ диагностики нарушения энергетического метаболизма лимфоцитов при внебольничной пневмонии у детей
CN110517776B (zh) * 2019-08-16 2023-06-16 四川大学华西医院 一种老年人健康风险评估方法及其应用
CN115141801B (zh) * 2022-08-16 2024-01-26 中国医学科学院血液病医院(中国医学科学院血液学研究所) 基于线粒体代谢活性分析不同淋巴细胞亚群的方法、试剂盒及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1046714A2 (fr) * 1999-04-20 2000-10-25 Universita' degli studi di Bologna Une méthode et trousse pour mesurer l'activité mitochondriale

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1046714A2 (fr) * 1999-04-20 2000-10-25 Universita' degli studi di Bologna Une méthode et trousse pour mesurer l'activité mitochondriale

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D'AURELIO MARILENA ET AL: "Decreased Pasteur effect in platelets of aged individuals", MECHANISMS OF AGEING AND DEVELOPMENT, vol. 122, no. 8, June 2001 (2001-06-01), pages 823 - 833, XP001172496, ISSN: 0047-6374 *
LENAZ GIORGIO ET AL: "Role of mitochondria in oxidative stress and aging.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. UNITED STATES APR 2002, vol. 959, April 2002 (2002-04-01), pages 199 - 213, XP008024217, ISSN: 0077-8923 *
MOLINA J A ET AL: "Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease", NEUROLOGY, vol. 48, no. 3, 1997, pages 636 - 638, XP008024279, ISSN: 0028-3878 *

Also Published As

Publication number Publication date
AU2003230209A1 (en) 2003-12-12
ITMI20021147A1 (it) 2003-11-28
WO2003100088A2 (fr) 2003-12-04
ITMI20021147A0 (it) 2002-05-28

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