WO2003097857A3 - Method for the detection of aquaretic compounds - Google Patents

Method for the detection of aquaretic compounds Download PDF

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Publication number
WO2003097857A3
WO2003097857A3 PCT/DK2003/000328 DK0300328W WO03097857A3 WO 2003097857 A3 WO2003097857 A3 WO 2003097857A3 DK 0300328 W DK0300328 W DK 0300328W WO 03097857 A3 WO03097857 A3 WO 03097857A3
Authority
WO
WIPO (PCT)
Prior art keywords
aquaretic
aquaporin
mammal
compounds
detection
Prior art date
Application number
PCT/DK2003/000328
Other languages
French (fr)
Other versions
WO2003097857A2 (en
Inventor
Thomas Jonassen
Niels Hadrup
Joergen Soeberg Petersen
Original Assignee
Zealand Pharma As
Thomas Jonassen
Niels Hadrup
Joergen Soeberg Petersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As, Thomas Jonassen, Niels Hadrup, Joergen Soeberg Petersen filed Critical Zealand Pharma As
Priority to AU2003236206A priority Critical patent/AU2003236206A1/en
Publication of WO2003097857A2 publication Critical patent/WO2003097857A2/en
Publication of WO2003097857A3 publication Critical patent/WO2003097857A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions.
PCT/DK2003/000328 2002-05-17 2003-05-15 Method for the detection of aquaretic compounds WO2003097857A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003236206A AU2003236206A1 (en) 2002-05-17 2003-05-15 Method for the detection of aquaretic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38152102P 2002-05-17 2002-05-17
US60/381,521 2002-05-17

Publications (2)

Publication Number Publication Date
WO2003097857A2 WO2003097857A2 (en) 2003-11-27
WO2003097857A3 true WO2003097857A3 (en) 2004-01-08

Family

ID=29550138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000328 WO2003097857A2 (en) 2002-05-17 2003-05-15 Method for the detection of aquaretic compounds

Country Status (2)

Country Link
AU (1) AU2003236206A1 (en)
WO (1) WO2003097857A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840696A (en) * 1997-09-11 1998-11-24 Lippton; Howard Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ)
WO2001098324A1 (en) * 2000-06-16 2001-12-27 Zealand Pharma A/S Peptide conjugates modified n- and/or c-terminally by short charged peptide chains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840696A (en) * 1997-09-11 1998-11-24 Lippton; Howard Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ)
WO2001098324A1 (en) * 2000-06-16 2001-12-27 Zealand Pharma A/S Peptide conjugates modified n- and/or c-terminally by short charged peptide chains

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DANIEL R. KAPUSTA: "Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function", PEPTIDES, vol. 21, 2000, pages 1081 - 1099, XP002257112 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; March 2003 (2003-03-01), HADRUP NIELS ET AL: "ORL1 stimulation does not inhibit vasopressin mediated cAMP formation in rat inner medullary collecting ducts.", XP002257113, Database accession no. PREV200300295565 *
FASEB JOURNAL, vol. 17, no. 4-5, March 2003 (2003-03-01), FASEB Meeting on Experimental Biology: Translating the Genome;San Diego, CA, USA; April 11-15, 2003, pages Abstract No. 333.8, ISSN: 0892-6638 (ISSN print) *
THOMAS E JONASSEN ET AL: "The Aquaretic effect of the nociceptin analogue ZP120C is associated with marked downregulation of aquaporin 2", AMERICAN HEART ASSOCIATION. SCIENTIFIC SESSIONS 2002, CIRCULATION, vol. 106, no. 19 (Suppl. II), November 2002 (2002-11-01), Chicago, Illinois, USA, pages II - 135, XP002257110 *
THOMAS E. N. JONASSEN ET AL: "Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade", AM. J. PHYSIOL. RENAL PHYSIOL., vol. 278, 2000, pages F246 - F256, XP002257111 *

Also Published As

Publication number Publication date
WO2003097857A2 (en) 2003-11-27
AU2003236206A1 (en) 2003-12-02
AU2003236206A8 (en) 2003-12-02

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