WO2003095605A3 - A chimeric reverse transcriptase and methods for identifying telomerase inhibitors - Google Patents
A chimeric reverse transcriptase and methods for identifying telomerase inhibitors Download PDFInfo
- Publication number
- WO2003095605A3 WO2003095605A3 PCT/EP2003/003874 EP0303874W WO03095605A3 WO 2003095605 A3 WO2003095605 A3 WO 2003095605A3 EP 0303874 W EP0303874 W EP 0303874W WO 03095605 A3 WO03095605 A3 WO 03095605A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reverse transcriptase
- hiv
- htert
- methods
- telomerase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03722473A EP1504090A2 (en) | 2002-05-08 | 2003-04-14 | A chimeric reverse transcriptase and methods for identifying telomerase inhibitors |
JP2004503599A JP2005524409A (en) | 2002-05-08 | 2003-04-14 | Methods for identifying chimeric reverse transcriptase and telomerase inhibitors |
AU2003229666A AU2003229666A1 (en) | 2002-05-08 | 2003-04-14 | A chimeric reverse transcriptase and methods for identifying telomerase inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37882002P | 2002-05-08 | 2002-05-08 | |
US60/378,820 | 2002-05-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003095605A2 WO2003095605A2 (en) | 2003-11-20 |
WO2003095605A3 true WO2003095605A3 (en) | 2004-02-19 |
Family
ID=29420443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/003874 WO2003095605A2 (en) | 2002-05-08 | 2003-04-14 | A chimeric reverse transcriptase and methods for identifying telomerase inhibitors |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1504090A2 (en) |
JP (1) | JP2005524409A (en) |
AU (1) | AU2003229666A1 (en) |
WO (1) | WO2003095605A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2536830T3 (en) | 2010-02-16 | 2019-10-21 | Ultimovacs As | POLYPEPTIDES |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0185444A2 (en) * | 1984-10-10 | 1986-06-25 | Centocor, Inc. | Cloning and expression of HTLV-III DNA |
WO1990010230A1 (en) * | 1989-02-23 | 1990-09-07 | University Of Ottawa | Polypeptide having immunological activity for use as diagnostic reagent and/or vaccine |
WO2001007661A2 (en) * | 1999-07-23 | 2001-02-01 | Gen-Probe Incorporated | Polynucleotide amplification method |
WO2001046408A2 (en) * | 1999-12-23 | 2001-06-28 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular clones with mutated hiv gag/pol, siv gag and siv env genes |
-
2003
- 2003-04-14 JP JP2004503599A patent/JP2005524409A/en active Pending
- 2003-04-14 EP EP03722473A patent/EP1504090A2/en not_active Withdrawn
- 2003-04-14 WO PCT/EP2003/003874 patent/WO2003095605A2/en not_active Application Discontinuation
- 2003-04-14 AU AU2003229666A patent/AU2003229666A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0185444A2 (en) * | 1984-10-10 | 1986-06-25 | Centocor, Inc. | Cloning and expression of HTLV-III DNA |
WO1990010230A1 (en) * | 1989-02-23 | 1990-09-07 | University Of Ottawa | Polypeptide having immunological activity for use as diagnostic reagent and/or vaccine |
WO2001007661A2 (en) * | 1999-07-23 | 2001-02-01 | Gen-Probe Incorporated | Polynucleotide amplification method |
WO2001046408A2 (en) * | 1999-12-23 | 2001-06-28 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular clones with mutated hiv gag/pol, siv gag and siv env genes |
Non-Patent Citations (5)
Title |
---|
BOSOY DIMITRY ET AL: "Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 49, 7 December 2001 (2001-12-07), pages 46305 - 46312, XP002264364, ISSN: 0021-9258 * |
KAUR H ET AL: "Preparation of monoclonal antibodies against human telomerase", HYBRIDOMA, vol. 20, no. 3, June 2001 (2001-06-01), pages 183 - 188, XP009022718, ISSN: 0272-457X * |
MITCHELL JAMES R ET AL: "Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase", MOLECULAR CELL, vol. 6, no. 2, August 2000 (2000-08-01), pages 361 - 371, XP002264363, ISSN: 1097-2765 * |
PENG YUN ET AL: "Analysis of telomerase processivity: Mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance", MOLECULAR CELL, vol. 7, no. 6, June 2001 (2001-06-01), pages 1201 - 1211, XP002264362, ISSN: 1097-2765 * |
ZHU HAIYAN ET AL: "The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis", JOURNAL OF NEUROCHEMISTRY, vol. 75, no. 1, July 2000 (2000-07-01), pages 117 - 124, XP002264365, ISSN: 0022-3042 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003229666A1 (en) | 2003-11-11 |
EP1504090A2 (en) | 2005-02-09 |
JP2005524409A (en) | 2005-08-18 |
WO2003095605A2 (en) | 2003-11-20 |
AU2003229666A8 (en) | 2003-11-11 |
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