WO2003093826A3 - Assays for identifying cholesterol - lowering molecules - Google Patents

Assays for identifying cholesterol - lowering molecules Download PDF

Info

Publication number
WO2003093826A3
WO2003093826A3 PCT/IB2003/002376 IB0302376W WO03093826A3 WO 2003093826 A3 WO2003093826 A3 WO 2003093826A3 IB 0302376 W IB0302376 W IB 0302376W WO 03093826 A3 WO03093826 A3 WO 03093826A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
treatment
molecules
assays
identification
Prior art date
Application number
PCT/IB2003/002376
Other languages
French (fr)
Other versions
WO2003093826A2 (en
Inventor
Stephane Benjamin
Catherine Clusel
Aurelie Daury
Laurent Essioux
Original Assignee
Clinigenetics
Stephane Benjamin
Catherine Clusel
Aurelie Daury
Laurent Essioux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinigenetics, Stephane Benjamin, Catherine Clusel, Aurelie Daury, Laurent Essioux filed Critical Clinigenetics
Priority to AU2003233124A priority Critical patent/AU2003233124A1/en
Publication of WO2003093826A2 publication Critical patent/WO2003093826A2/en
Publication of WO2003093826A3 publication Critical patent/WO2003093826A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a gene and the encoded protein involved in cholesterol lowering, and their use in diagnostics, treatment of disease, and in the identification of molecules for the treatment and prevention of disease. The present invention thus discloses methods of screening for the identification of molecules useful in the treatment of heart disease, coronary artery disease, myocardial infarct, and lipid related metabolic disorders such as the dysmetabolic syndrome, Obesity and Diabetes type II.
PCT/IB2003/002376 2002-04-29 2003-04-29 Assays for identifying cholesterol - lowering molecules WO2003093826A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003233124A AU2003233124A1 (en) 2002-04-29 2003-04-29 Assays for identifying cholesterol - lowering molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37651002P 2002-04-29 2002-04-29
US60/376.510 2002-04-29
US40229002P 2002-08-09 2002-08-09
US60/402.290 2002-08-09

Publications (2)

Publication Number Publication Date
WO2003093826A2 WO2003093826A2 (en) 2003-11-13
WO2003093826A3 true WO2003093826A3 (en) 2004-12-02

Family

ID=29406760

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/002376 WO2003093826A2 (en) 2002-04-29 2003-04-29 Assays for identifying cholesterol - lowering molecules

Country Status (2)

Country Link
AU (1) AU2003233124A1 (en)
WO (1) WO2003093826A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051638A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Drug metabolizing enzymes
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002000677A1 (en) * 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2002026950A2 (en) * 2000-09-29 2002-04-04 Incyte Genomics, Inc. Transferases
US20020045271A1 (en) * 1998-06-10 2002-04-18 Licata And Tyrrell P.C. Compounds and methods for identifying compounds that interact with microsomal triglyceride transfer protein binding sites on apolipoprotein b and modulate lipid biosynthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020045271A1 (en) * 1998-06-10 2002-04-18 Licata And Tyrrell P.C. Compounds and methods for identifying compounds that interact with microsomal triglyceride transfer protein binding sites on apolipoprotein b and modulate lipid biosynthesis
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001051638A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Drug metabolizing enzymes
WO2002000677A1 (en) * 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2002026950A2 (en) * 2000-09-29 2002-04-04 Incyte Genomics, Inc. Transferases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GRAND-PERRET T ET AL: "SCAP ligands are potent new lipid-lowering drugs", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 7, no. 12, 2001, pages 1332 - 1338, XP002259713, ISSN: 1078-8956 *

Also Published As

Publication number Publication date
AU2003233124A1 (en) 2003-11-17
AU2003233124A8 (en) 2003-11-17
WO2003093826A2 (en) 2003-11-13

Similar Documents

Publication Publication Date Title
SI2482078T1 (en) Diagnosis of cardiovascular disease
WO2006096515A3 (en) Modified transferrin fusion proteins
WO2006108582A3 (en) Human marker genes and agents for diagnosis, treatment and prophylaxis of cardiovascular disorders and artherosclerosis
WO2004001421A3 (en) Method for the diagnosis and differential diagnosis of neurological diseases
AU2002257162A1 (en) Humanized antibodies
AU2003233437A1 (en) System for the diagnosis and monitoring of coronary artery disease, acute coronary syndromes, cardiomyopathy and other cardiac conditions
WO2002038794A3 (en) Cardiovascular disease diagnostic and therapeutic targets
WO2003085095A3 (en) Novel expressed genes
EP2287340A3 (en) Method for diagnosis and treatment of a mental disease
WO2004029072A3 (en) PrPsc -INTERACTING MOLECULES AND USES THEREOF
WO2010019519A3 (en) Method of using foxo3a polymorphisms and haplotypes to predict and promote healthy aging and longevity
WO2007150067A3 (en) Nutritional and exercise plan based on a person's individual genetic apo e genotype
CA2534643A1 (en) Methods for screening and identifying compounds
WO2005117941A3 (en) Methods and compositions for the treatment of polycystic diseases
WO2003093826A3 (en) Assays for identifying cholesterol - lowering molecules
WO2005095973A3 (en) Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54)
WO2004092740A3 (en) Methods for identifying therapeutic targets involved in glucose and lipid metabolism
BRPI0411353A (en) modified corina molecules having surrogate activation sequences and applications thereof
WO2003048204A1 (en) Alzheimer’s disease-associated gene and protein and use thereof
WO2006104586A3 (en) Methods of diagnosis and treatment of metabolic disorders
JP2005500813A5 (en)
WO2005022164A3 (en) Diagnostics and therapeutics for diseases associated with kallikrein 8 (klk8)
AU2002325328A1 (en) Asthma-associated gene
WO2005040825A3 (en) Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 20 (gpr20)
WO2006129058A3 (en) Screening and treatment of alzheimer's disease

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP