WO2003093787A3 - Antiproliferative protein from hypericum perforatum and nucleic acids encoding the same - Google Patents

Antiproliferative protein from hypericum perforatum and nucleic acids encoding the same Download PDF

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Publication number
WO2003093787A3
WO2003093787A3 PCT/US2003/013154 US0313154W WO03093787A3 WO 2003093787 A3 WO2003093787 A3 WO 2003093787A3 US 0313154 W US0313154 W US 0313154W WO 03093787 A3 WO03093787 A3 WO 03093787A3
Authority
WO
WIPO (PCT)
Prior art keywords
hypericum perforatum
chp
same
nucleic acids
acids encoding
Prior art date
Application number
PCT/US2003/013154
Other languages
French (fr)
Other versions
WO2003093787A2 (en
Inventor
Kamel Khalili
Nune Darbinian Sarkissian
Original Assignee
Univ Temple
Kamel Khalili
Nune Darbinian Sarkissian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple, Kamel Khalili, Nune Darbinian Sarkissian filed Critical Univ Temple
Priority to AU2003245247A priority Critical patent/AU2003245247A1/en
Publication of WO2003093787A2 publication Critical patent/WO2003093787A2/en
Publication of WO2003093787A3 publication Critical patent/WO2003093787A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A protein named CHP-10 has been isolated from Hypericum perforatum callus culture. This protein comprises a unique 20 amino acid sequence, has an apparent molecular weight of approximately 39 kDa by SDS-PAGE, and inhibits proliferation of abnormally proliferating cells from cancer or non-cancerous proliferative disorders. Methods of using CHP-10, or fragments, derivatives, homologs and analogs of CHP-10, to inhibit the proliferation of abnormally proliferating cells are also provided.
PCT/US2003/013154 2002-04-30 2003-04-28 Antiproliferative protein from hypericum perforatum and nucleic acids encoding the same WO2003093787A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003245247A AU2003245247A1 (en) 2002-04-30 2003-04-28 Antiproliferative protein from hypericum perforatum and nucleic acids encoding the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37699602P 2002-04-30 2002-04-30
US60/376,996 2002-04-30

Publications (2)

Publication Number Publication Date
WO2003093787A2 WO2003093787A2 (en) 2003-11-13
WO2003093787A3 true WO2003093787A3 (en) 2004-06-03

Family

ID=29401430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013154 WO2003093787A2 (en) 2002-04-30 2003-04-28 Antiproliferative protein from hypericum perforatum and nucleic acids encoding the same

Country Status (2)

Country Link
AU (1) AU2003245247A1 (en)
WO (1) WO2003093787A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101121883B1 (en) * 2010-11-24 2012-03-20 주식회사 바이오에프디엔씨 A skin external composition containing callus extract drived from saint john's wart

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1692045A1 (en) * 1968-03-14 1971-05-06 Werner Blaesius Medicinal herbal extracts for carrying hand and foot baths against chronic diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1692045A1 (en) * 1968-03-14 1971-05-06 Werner Blaesius Medicinal herbal extracts for carrying hand and foot baths against chronic diseases

Also Published As

Publication number Publication date
AU2003245247A8 (en) 2003-11-17
AU2003245247A1 (en) 2003-11-17
WO2003093787A2 (en) 2003-11-13

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