WO2003091723A3 - Device for controlled drying and derivatization in planar chromatography and its application - Google Patents

Device for controlled drying and derivatization in planar chromatography and its application Download PDF

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Publication number
WO2003091723A3
WO2003091723A3 PCT/SI2003/000012 SI0300012W WO03091723A3 WO 2003091723 A3 WO2003091723 A3 WO 2003091723A3 SI 0300012 W SI0300012 W SI 0300012W WO 03091723 A3 WO03091723 A3 WO 03091723A3
Authority
WO
WIPO (PCT)
Prior art keywords
reproducibility
minimum
heated air
derivatization
inventive device
Prior art date
Application number
PCT/SI2003/000012
Other languages
French (fr)
Other versions
WO2003091723A2 (en
Inventor
Mirko Prosek
Irena Vovk
Wondra Alenka Golc
Janko Zmitek
Original Assignee
Kemijski Inst
Mirko Prosek
Irena Vovk
Wondra Alenka Golc
Janko Zmitek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kemijski Inst, Mirko Prosek, Irena Vovk, Wondra Alenka Golc, Janko Zmitek filed Critical Kemijski Inst
Priority to DE10392483T priority Critical patent/DE10392483T5/en
Priority to AU2003262558A priority patent/AU2003262558A1/en
Publication of WO2003091723A2 publication Critical patent/WO2003091723A2/en
Publication of WO2003091723A3 publication Critical patent/WO2003091723A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/94—Development
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/95—Detectors specially adapted therefor; Signal analysis

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

The inventive device allows to substantially improve the reproducibility of measurements in quantitative thin-layer chromatography (TLC and HPTLC). Accuracy, sensitivity and reproducibility are improved by eliminating the uncontrolled band broadening resulting from diffusion, nonuniform vertical in-depth distribution of spots in the sorbent layer during drying, and nonhomogeneous derivatization conditions. The main characteristics of the inventive device are as follows: the heated air flow is directed over the sorbent layer in the direction of chromatogram development. The temperature of the heated air is preferably not constant but regularly oscillating between a minimum and a maximum value. The range between the minimum and the maximum temperature values, as well as the length of the oscillation interval, may be regulated using a dedicated program. The device also supports computerized drying and automated operation through integration into a complete system for processing and evaluating chromatograms and results.
PCT/SI2003/000012 2002-04-26 2003-04-17 Device for controlled drying and derivatization in planar chromatography and its application WO2003091723A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE10392483T DE10392483T5 (en) 2002-04-26 2003-04-17 Apparatus for controlled drying and derivatization in planar chromatography, and their use
AU2003262558A AU2003262558A1 (en) 2002-04-26 2003-04-17 Device for controlled drying and derivatization in planar chromatography and its application

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200200115A SI21199A (en) 2002-04-26 2002-04-26 Device for controlled drying and derivatization in chromatography on plates and its use
SIP-0200115 2002-04-26

Publications (2)

Publication Number Publication Date
WO2003091723A2 WO2003091723A2 (en) 2003-11-06
WO2003091723A3 true WO2003091723A3 (en) 2004-03-18

Family

ID=29247059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2003/000012 WO2003091723A2 (en) 2002-04-26 2003-04-17 Device for controlled drying and derivatization in planar chromatography and its application

Country Status (4)

Country Link
AU (1) AU2003262558A1 (en)
DE (1) DE10392483T5 (en)
SI (1) SI21199A (en)
WO (1) WO2003091723A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9607816B2 (en) 2014-12-17 2017-03-28 Micromass Uk Limited Two-dimensional separation and imaging technique for the rapid analysis of biological samples
GB2535835B (en) * 2014-12-17 2019-09-04 Micromass Ltd A two-dimensional separation and imaging technique for the rapid analysis of biological samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3229505A (en) * 1963-04-01 1966-01-18 Phillips Petroleum Co Paper chromatography
US3904372A (en) * 1973-01-11 1975-09-09 Gene E Lightner Automatic thin layer chromatographic apparatus
US4125464A (en) * 1976-10-15 1978-11-14 Bayer Aktiengesellschaft Method and apparatus for multiple development of thin-layer chromatography plates
US4812241A (en) * 1987-08-14 1989-03-14 Laser Precision Corporation Sample transfer for infrared analysis in thin layer chromatography-structure & method
US5306645A (en) * 1990-01-31 1994-04-26 Shimadzu Corporation Concentration and transfer methods for a chromatogram and an LC/IR measuring method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3229505A (en) * 1963-04-01 1966-01-18 Phillips Petroleum Co Paper chromatography
US3904372A (en) * 1973-01-11 1975-09-09 Gene E Lightner Automatic thin layer chromatographic apparatus
US4125464A (en) * 1976-10-15 1978-11-14 Bayer Aktiengesellschaft Method and apparatus for multiple development of thin-layer chromatography plates
US4812241A (en) * 1987-08-14 1989-03-14 Laser Precision Corporation Sample transfer for infrared analysis in thin layer chromatography-structure & method
US5306645A (en) * 1990-01-31 1994-04-26 Shimadzu Corporation Concentration and transfer methods for a chromatogram and an LC/IR measuring method

Also Published As

Publication number Publication date
WO2003091723A2 (en) 2003-11-06
DE10392483T5 (en) 2005-03-03
AU2003262558A1 (en) 2003-11-10
SI21199A (en) 2003-10-31

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