WO2003090754A1 - Utilisation de la dhea pour le traitement de l'hypopituitarisme chez la femme - Google Patents

Utilisation de la dhea pour le traitement de l'hypopituitarisme chez la femme Download PDF

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Publication number
WO2003090754A1
WO2003090754A1 PCT/SE2003/000644 SE0300644W WO03090754A1 WO 2003090754 A1 WO2003090754 A1 WO 2003090754A1 SE 0300644 W SE0300644 W SE 0300644W WO 03090754 A1 WO03090754 A1 WO 03090754A1
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WO
WIPO (PCT)
Prior art keywords
dhea
women
treatment
female
effects
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Application number
PCT/SE2003/000644
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English (en)
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WO2003090754A9 (fr
Inventor
Bengt-Åke BENGTSSON
Gudmundur Johannsson
Original Assignee
Sahltech I Göteborg AB
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Application filed by Sahltech I Göteborg AB filed Critical Sahltech I Göteborg AB
Priority to AU2003224561A priority Critical patent/AU2003224561A1/en
Publication of WO2003090754A1 publication Critical patent/WO2003090754A1/fr
Publication of WO2003090754A9 publication Critical patent/WO2003090754A9/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Selon l'invention, une faible dose de déshydroépiandrostérone modifie le comportement des femmes atteintes d'hypopituitarisme et ne présentant pas de carence.
PCT/SE2003/000644 2002-04-23 2003-04-22 Utilisation de la dhea pour le traitement de l'hypopituitarisme chez la femme WO2003090754A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003224561A AU2003224561A1 (en) 2002-04-23 2003-04-22 Use of dhea for treatment of female hypopituitarism

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37488202P 2002-04-23 2002-04-23
US60/374,882 2002-04-23

Publications (2)

Publication Number Publication Date
WO2003090754A1 true WO2003090754A1 (fr) 2003-11-06
WO2003090754A9 WO2003090754A9 (fr) 2004-06-10

Family

ID=29270562

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2003/000644 WO2003090754A1 (fr) 2002-04-23 2003-04-22 Utilisation de la dhea pour le traitement de l'hypopituitarisme chez la femme

Country Status (2)

Country Link
AU (1) AU2003224561A1 (fr)
WO (1) WO2003090754A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112394102A (zh) * 2020-11-05 2021-02-23 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843932A (en) * 1993-01-19 1998-12-01 Endorcaherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
US5861391A (en) * 1997-01-29 1999-01-19 Research Development Foundation Use of dehydroepiandrosterone to treat primary adrenal insufficiency and Addison's disease
US5955455A (en) * 1993-01-19 1999-09-21 Endorecherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
WO1999063973A2 (fr) * 1998-06-11 1999-12-16 Endorecherche, Inc. COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS POUR L'ANDROST-5-ENE-3β,17β-DIOL

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843932A (en) * 1993-01-19 1998-12-01 Endorcaherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
US5955455A (en) * 1993-01-19 1999-09-21 Endorecherche, Inc. Therapeutic methods and delivery systems utilizing sex steroid precursors
US5861391A (en) * 1997-01-29 1999-01-19 Research Development Foundation Use of dehydroepiandrosterone to treat primary adrenal insufficiency and Addison's disease
WO1999063973A2 (fr) * 1998-06-11 1999-12-16 Endorecherche, Inc. COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS POUR L'ANDROST-5-ENE-3β,17β-DIOL
US6432940B1 (en) * 1998-06-11 2002-08-13 Endorecherche, Inc. Uses for androst-5-ene-3β, 17β-diol

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ARLT WIEBKE ET AL.: "Dehydroepiandrosterone replacement in women with adrenal insufficiency", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 341, no. 14, 1999, pages 1013 - 1020, XP002967345 *
BURGER HENRY G.: "Androgen production in women", FERTILITY AND STERILITY, vol. 77, no. 4, SUPPL. 4, 2002, pages S3 - S5, XP002967343 *
HUNT PENELOPE J. ET AL.: "Improvement in mood and fatigue after dehydroepiandrosterone replacement Addison's disease in a randomized double blind trial", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 85, no. 12, 2000, pages 4650 - 4656, XP002967346 *
ILONDO M.M. ET AL.: "Plasma androgens in children and adolescents", HORMONE RES., vol. 16, 1982, pages 78 - 95, XP002967344 *
JOHANNSSON ET AL.: "Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 87, no. 5, 2002, pages 2046 - 2052, XP002967339 *
MILLER KAREN K. ET AL.: "Androgen deficiency in women with hypopituitarism", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 86, no. 2, 2001, pages 561 - 567, XP002967340 *
SESMILO GEMMA ET AL.: "Inflammatory cardiovascular risk markers in women with hypopituitarism", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 86, no. 12, 2001, pages 5774 - 5781, XP002967341 *
YOUNG JACQUES ET AL.: "Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 82, no. 8, 1997, pages 2578 - 2585, XP002967342 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112394102A (zh) * 2020-11-05 2021-02-23 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
CN112394102B (zh) * 2020-11-05 2023-05-26 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用

Also Published As

Publication number Publication date
WO2003090754A9 (fr) 2004-06-10
AU2003224561A1 (en) 2003-11-10

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